List of works - J Pedro Simas

A secreted chemokine binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load

scientific article

A single CD8+ T cell epitope sets the long-term latent load of a murid herpesvirus

scientific article

Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytes

scientific article

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

scientific article published on 31 October 2013

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.

scientific article published on 14 September 2017

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

scientific article

Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation

scientific article (publication date: June 2014)

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

scientific article

Establishment of murine gammaherpesvirus latency in B cells is not a stochastic event.

scientific article

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

scientific article published on 12 July 2016

Gamma-herpesvirus colonization of the spleen requires lytic replication in B cells.

scientific article published on 17 January 2018

Identification of H-type BSE in Portugal

scientific article

Identification of putative atypical scrapie in sheep in Portugal.

scientific article published in November 2004

In vivo persistence of chimeric virus after substitution of the KSHV LANA DNA binding domain with that of MuHV-4

scientific article published on 12 October 2018

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

scientific article published on 9 August 2005

K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus.

scientific article published on 8 July 2002

KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence

scientific article published on 20 August 2020

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.

scientific article published on 30 September 2015

Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation

scientific article published on 15 June 2016

MLL1 is regulated by KSHV LANA and is important for virus latency

scientific article published on 01 December 2021

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.

scientific article published on 19 March 2014

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells.

scientific article published on 6 November 2015

Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells.

scientific article published on 2 September 2005

Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence

scientific article

Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo.

scientific article published in January 2005

ORF73 of murine herpesvirus-68 is critical for the establishment and maintenance of latency.

scientific article published in December 2003

Putative emergence of classical scrapie in a background of enzootic atypical scrapie.

scientific article published on 17 February 2010

Role of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein

scientific article published on 20 December 2012

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation ⬇️

scientific article published on August 8, 2013

T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis

scientific article published on 16 July 2012

Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase

scientific article

The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly

scientific article

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence.

scientific article

The M2 gene product of murine gammaherpesvirus 68 is required for efficient colonization of splenic follicles but is not necessary for expansion of latently infected germinal centre B cells

scientific article published on October 2004

Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection.

scientific article published on 27 July 2016

Vaccine protection against murid herpesvirus-4 is maintained when the priming virus lacks known latency genes

scientific article published on 21 November 2019

List of works by J Pedro Simas

A secreted chemokine binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load

A single CD8+ T cell epitope sets the long-term latent load of a murid herpesvirus

Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytes

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

Establishment of murine gammaherpesvirus latency in B cells is not a stochastic event.

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

Gamma-herpesvirus colonization of the spleen requires lytic replication in B cells.

Identification of H-type BSE in Portugal

Identification of putative atypical scrapie in sheep in Portugal.

In vivo persistence of chimeric virus after substitution of the KSHV LANA DNA binding domain with that of MuHV-4

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus.

KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.

Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation

MLL1 is regulated by KSHV LANA and is important for virus latency

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells.

Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells.

Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence

Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo.

ORF73 of murine herpesvirus-68 is critical for the establishment and maintenance of latency.

Putative emergence of classical scrapie in a background of enzootic atypical scrapie.

Role of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation ⬇️

T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis

Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase

The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence.

The M2 gene product of murine gammaherpesvirus 68 is required for efficient colonization of splenic follicles but is not necessary for expansion of latently infected germinal centre B cells

Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection.

Vaccine protection against murid herpesvirus-4 is maintained when the priming virus lacks known latency genes