List of works - Amy D. Klion

A high malaria reinfection rate in children and young adults living under a low entomological inoculation rate in a periurban area of Bamako, Mali

scientific article

A novel developmentally regulated galectin of Onchocerca volvulus

scientific article published in February 2000

A randomized trial of doxycycline for Mansonella perstans infection

scientific article

AETIOLOGY OF OESOPHAGEAL CANCER

scientific article published in The Lancet

Analysis of nematode motion using an improved light-scatter based system

scientific article (publication date: February 2015)

Anti-interleukin-5 therapy for asthma and hypereosinophilic syndrome

scientific article published in November 2004

Approach to the therapy of hypereosinophilic syndromes

scientific article published on August 2007

Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report

scientific article

At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells

scientific article

Biologic therapies targeting eosinophils: current status and future prospects ⬇️

scientific article published on March 2015

Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: Review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8 ⬇️

scientific article published on June 6, 2012

CD2 identifies a monocyte subpopulation with immunoglobulin E-dependent, high-level expression of Fc epsilon RI

scientific article

Charcot-Leyden crystals: solving an enigma

scholarly article by Amy D. Klion published 15 November 2018 in Blood

Chronic active Epstein-Barr virus infection: a novel cause of lymphocytic variant hypereosinophilic syndrome

scientific article published in March 2013

Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes

scientific article

Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis.

scientific article

Development of a suspension array assay in multiplex for the simultaneous measurement of serum levels of four eosinophil granule proteins

scientific article

Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes

scientific article published on 08 May 2018

Diethylcarbamazine (DEC)

Dysregulation of interleukin 5 expression in familial eosinophilia

scientific article

Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections

scientific article

Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome

scientific article published on 01 July 2007

Eosinophilia: Introduction ⬇️

scientific article published on April 1, 2012

Eosinophils in vasculitis: characteristics and roles in pathogenesis

scientific article published on 8 July 2014

Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder

scientific article

Expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower CCR1 expression

scientific article

Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.

scientific article

Filaria-induced monocyte dysfunction and its reversal following treatment

scientific article

Filarial infection suppresses malaria-specific multifunctional Th1 and Th17 responses in malaria and filarial coinfections

scientific article

Filarial infections in travelers and immigrants

scientific article

Filariasis attenuates anemia and proinflammatory responses associated with clinical malaria: a matched prospective study in children and young adults

scientific article

Filariasis in travelers presenting to the GeoSentinel Surveillance Network

scientific article

Genetic heterogeneity in Loa loa parasites from southern Cameroon: A preliminary study

scientific article

Glucocorticoid-induced eosinopenia in humans can be linked to early transcriptional events

scientific article published on 17 July 2018

Highly heterogeneous, activated, and short-lived regulatory T cells during chronic filarial infection

scientific article published on 22 May 2014

How I treat hypereosinophilic syndromes

scientific article published on 19 August 2009

How I treat hypereosinophilic syndromes.

scientific article

Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy

scientific article

Hypereosinophilic syndrome: current approach to diagnosis and treatment.

scientific article published on January 2009

ICON: Eosinophil Disorders ⬇️

scientific article published on December 1, 2012

IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis

scientific article

Imatinib-responsive hypereosinophilia in a patient with B cell ALL.

scientific article published in December 2004

Interferon regulatory factor modulation underlies the bystander suppression of malaria antigen-driven IL-12 and IFN-γ in filaria-malaria co-infection

scientific article

KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities

scientific article published on 12 July 2007

KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells

scientific article published on 04 June 2013

Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes

scientific article published on 4 October 2012

Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection

scientific article published on December 2009

Marked and persistent eosinophilia in the absence of clinical manifestations.

scientific article published on 26 August 2013

Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome

scientific article

Miscellaneous Filariae

Molecular identification of Wolbachia from the filarial nematode Mansonella perstans

scientific article published on 2 May 2008

Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome

scientific article

Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome

scientific article

Novel targeted therapies for eosinophil-associated diseases and allergy

scientific article

Novel targeted therapies for eosinophilic disorders

scientific article published on September 2012

Onchocerciasis in a nonendemic population: clinical and immunologic assessment before treatment and at the time of presumed cure

scientific article published on 20 December 2000

Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population

scientific article published on 26 June 2009

Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field

scientific article

Peripheral blood stem cell transplant-related Plasmodium falciparum infection in a patient with sickle cell disease

scientific article

Platelet-derived growth factor receptor-alpha-associated hypereosinophilic syndrome and lymphomatoid papulosis

scientific article

Pruritus and eosinophilia in a 14-year-old girl from Liberia

scientific article published in September 2001

Rapid development of migratory, linear, and serpiginous lesions in association with immunosuppression

scientific article

Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti–IL-5 antibody SCH55700

scientific article published on 01 December 2004

Recent advances in understanding eosinophil biology

scientific article

Refining the definition of hypereosinophilic syndrome

scientific article

Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing

scientific article

Reply: To PMID 23987798.

scientific article published on 16 January 2014

Safety and efficacy of the monoclonal anti-interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome

scientific article

Serum biomarkers are similar in Churg-Strauss syndrome and hypereosinophilic syndrome

scientific article

Serum immunoglobulin G4 antibodies to the recombinant antigen, Ll-SXP-1, are highly specific for Loa loa infection

scientific article

Siglec-7 on peripheral blood eosinophils: Surface expression and function

scientific article published on 26 February 2019

Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance

scientific article published on 25 December 2013

The FAR proteins of filarial nematodes: secretion, glycosylation and lipid binding characteristics

scientific article

The consequences of not having eosinophils.

scientific article published on 06 June 2013

The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders

scientific article

The etiology of severe anemia in a village and a periurban area in Mali

scientific article published on 27 April 2004

The relationship between serum IgE and surface levels of FcϵR on human leukocytes in various diseases: Correlation of expression with FcϵRI on basophils but not on monocytes or eosinophils

article

The role of eosinophils in host defense against helminth parasites

scientific article published on January 2004

Therapeutic Approaches to Patients With Hypereosinophilic Syndromes ⬇️

scientific article published on April 1, 2012

Treatment of patients with the hypereosinophilic syndrome with mepolizumab

scientific article

Use of high-dose, twice-yearly albendazole and ivermectin to suppress Wuchereria bancrofti microfilarial levels

scientific article

Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD).

scientific article

Wuchereria bancrofti transmission pattern in southern Mali prior to and following the institution of mass drug administration

scientific article published on 28 August 2013

List of works by Amy D. Klion

A high malaria reinfection rate in children and young adults living under a low entomological inoculation rate in a periurban area of Bamako, Mali

A novel developmentally regulated galectin of Onchocerca volvulus

A randomized trial of doxycycline for Mansonella perstans infection

AETIOLOGY OF OESOPHAGEAL CANCER

Analysis of nematode motion using an improved light-scatter based system

Anti-interleukin-5 therapy for asthma and hypereosinophilic syndrome

Approach to the therapy of hypereosinophilic syndromes

Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report

At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells

Biologic therapies targeting eosinophils: current status and future prospects ⬇️

Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: Review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8 ⬇️

CD2 identifies a monocyte subpopulation with immunoglobulin E-dependent, high-level expression of Fc epsilon RI

Charcot-Leyden crystals: solving an enigma

Chronic active Epstein-Barr virus infection: a novel cause of lymphocytic variant hypereosinophilic syndrome

Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes

Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis.

Development of a suspension array assay in multiplex for the simultaneous measurement of serum levels of four eosinophil granule proteins

Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes

Diethylcarbamazine (DEC)

Dysregulation of interleukin 5 expression in familial eosinophilia

Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections

Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome

Eosinophilia: Introduction ⬇️

Eosinophils in vasculitis: characteristics and roles in pathogenesis

Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder

Expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower CCR1 expression

Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.

Filaria-induced monocyte dysfunction and its reversal following treatment

Filarial infection suppresses malaria-specific multifunctional Th1 and Th17 responses in malaria and filarial coinfections

Filarial infections in travelers and immigrants

Filariasis attenuates anemia and proinflammatory responses associated with clinical malaria: a matched prospective study in children and young adults

Filariasis in travelers presenting to the GeoSentinel Surveillance Network

Genetic heterogeneity in Loa loa parasites from southern Cameroon: A preliminary study

Glucocorticoid-induced eosinopenia in humans can be linked to early transcriptional events

Highly heterogeneous, activated, and short-lived regulatory T cells during chronic filarial infection

How I treat hypereosinophilic syndromes

How I treat hypereosinophilic syndromes.

Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy

Hypereosinophilic syndrome: current approach to diagnosis and treatment.

ICON: Eosinophil Disorders ⬇️

IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis

Imatinib-responsive hypereosinophilia in a patient with B cell ALL.

Interferon regulatory factor modulation underlies the bystander suppression of malaria antigen-driven IL-12 and IFN-γ in filaria-malaria co-infection

KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities

KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells

Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes

Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection

Marked and persistent eosinophilia in the absence of clinical manifestations.

Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome

Miscellaneous Filariae

Molecular identification of Wolbachia from the filarial nematode Mansonella perstans

Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome

Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome

Novel targeted therapies for eosinophil-associated diseases and allergy

Novel targeted therapies for eosinophilic disorders

Onchocerciasis in a nonendemic population: clinical and immunologic assessment before treatment and at the time of presumed cure

Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population

Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field

Peripheral blood stem cell transplant-related Plasmodium falciparum infection in a patient with sickle cell disease

Platelet-derived growth factor receptor-alpha-associated hypereosinophilic syndrome and lymphomatoid papulosis

Pruritus and eosinophilia in a 14-year-old girl from Liberia

Rapid development of migratory, linear, and serpiginous lesions in association with immunosuppression

Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti–IL-5 antibody SCH55700

Recent advances in understanding eosinophil biology

Refining the definition of hypereosinophilic syndrome

Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing

Reply: To PMID 23987798.

Safety and efficacy of the monoclonal anti-interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome

Serum biomarkers are similar in Churg-Strauss syndrome and hypereosinophilic syndrome

Serum immunoglobulin G4 antibodies to the recombinant antigen, Ll-SXP-1, are highly specific for Loa loa infection

Siglec-7 on peripheral blood eosinophils: Surface expression and function

Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance

The FAR proteins of filarial nematodes: secretion, glycosylation and lipid binding characteristics

The consequences of not having eosinophils.

The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders

The etiology of severe anemia in a village and a periurban area in Mali

The relationship between serum IgE and surface levels of FcϵR on human leukocytes in various diseases: Correlation of expression with FcϵRI on basophils but not on monocytes or eosinophils

The role of eosinophils in host defense against helminth parasites

Therapeutic Approaches to Patients With Hypereosinophilic Syndromes ⬇️