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List of works by Toshimichi Shinohara

A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila

scientific article published on November 1, 1992

Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection.

scientific article

Analysis of the mouse γ-crystallin gene family: assignment of multiple cDNAs to discrete genomic sequences and characterization of a representative gene ⬇️

scientific article published on June 11, 1984

Anti-beta-crystallin antibodies (mouse) or sera from humans with age-related cataract are cytotoxic for lens epithelial cells in culture

scientific article published on 01 February 1997

Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture

scientific article published on 01 July 1999

Arrestin and phosducin are expressed in a small number of brain cells

scientific article published in December 1997

Assignment of the S-antigen gene (SAG) to human chromosome 2q24-q37

scientific article published on 01 May 1990

Biosynthesis, characterization, and efficacy in retinal degenerative diseases of lens epithelium-derived growth factor fragment (LEDGF1-326), a novel therapeutic protein.

scientific article

Cataract: window for systemic disorders

scientific article published on 06 March 2007

Cataracts: role of the unfolded protein response

scientific article

Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients

scientific article published on 01 January 1999

Cholesterol-derived bile acids enhance the chaperone activity of α-crystallins

scientific article published on 6 March 2011

Cloning, high level-expression and characterization of human lens thioltransferase

scientific article published on 01 April 1998

Cloning, high level-expression and characterization of human lens thioltransferase

scientific article published on 01 November 1999

Cone cells fail to develop normally in transgenic mice showing ablation of rod photoreceptor cells

scientific article published on 01 January 1994

Corticosteroids enhance S-antigen expression in nonretinal ocular tissues of rats with experimental autoimmune uveitis

scientific article published on 01 February 1994

DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF

scientific article published on 09 November 2005

Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis ⬇️

scientific article published on June 15, 2011

Detection of cytotoxic anti-LEDGF autoantibodies in atopic dermatitis

scientific article

Enhancement of S-antigen and its mRNA in the irides of uveitic patients

scientific article published in December 1992

Expression of extracellular calcium-sensing receptor by human lens epithelial cells.

scientific article

Immunization with recombinant Escherichia coli expressing retinal S-antigen-induced experimental autoimmune uveitis (EAU) in Lewis rats

scientific article published on 01 March 1993

Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation

scientific article published on 01 November 2006

LEDGF activation of PKC gamma and gap junction disassembly in lens epithelial cells

scientific article published in May 2003

LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes

scientific article published on 01 May 2001

LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity

scientific article published in August 2004

LEDGF, a survival factor, activates stress-related genes.

scientific article

Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells

scientific article published on 20 March 2003

Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts

scientific article (publication date: 7 January 2000)

Lens epithelium-derived growth factor: neuroprotection on rat retinal damage induced by N-methyl-D-aspartate

scientific article published in November 2003

Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells.

scientific article

Oligopeptides of three to five residues derived from uveitopathogenic sites of retinal S-antigen induce experimental autoimmune uveitis (EAU) in Lewis rats

scientific article published on 01 April 1993

Oral administration of lens homogenate suppresses antibody production in mice injected with beta-crystallin emulsified in CFA

scientific article published on 01 March 1997

Porcine S-antigen: cDNA sequence and expression in retina, ciliary epithelium and iris.

scientific article published on March 1996

Promoter demethylation of Keap1 gene in human diabetic cataractous lenses

scientific article published on 07 June 2012

Role of the unfolded protein response (UPR) in cataract formation.

scientific article published on 27 April 2006

S-antigen from the rat retina and pineal gland have identical sequences

scientific article published in July 1990

S-antigen: from gene to autoimmune uveitis.

scientific article published on June 1990

Scale-up methodology for the preparative purification of peptide M

scientific article published on 01 December 1988

Silencing gene therapy for mutant membrane, secretory, and lipid proteins in retinitis pigmentosa (RP).

scientific article published on 27 June 2007

Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

scientific article

Suppression of experimental autoimmune uveitis in rats by the oral administration of the uveitopathogenic S-antigen fragment or a cross-reactive homologous peptide

scientific article published in January 1992

The 5' flanking regions of IRBP and arrestin have promoter activity in primary embryonic chicken retina cell cultures

scientific article published on 01 February 1997

The sequence of human retinal S-antigen reveals similarities with alpha-transducin

scientific article

The sequence of the mouse phosducin-encoding gene and its 5'-flanking region

scientific journal article

Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF)

scientific article (publication date: 26 July 2002)

Transcription factor IID probes localize a single gene to the proximal region of mouse chromosome 17

scientific article published on 01 August 1993

Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress

scientific article (publication date: 28 December 2001)

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