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List of works by Frédéric Lynen

3D-LC-MS with <sup>2</sup>D Multimethod Option for Fully Automated Assessment of Multiple Attributes of Monoclonal Antibodies Directly from Cell Culture Supernatants

scientific article published in 2022

A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients

scientific article published on 11 January 2013

Analysis of bacterial fatty acids by flow modulated comprehensive two-dimensional gas chromatography with parallel flame ionization detector/mass spectrometry

scientific article

Application of the isopycnic kinetic plot method for elucidating the potential of sub-2 µm and core-shell particles in SFC.

scientific article published on 23 August 2013

Capillary liquid chromatography separations using non-porous pillar array columns

scientific article published on 25 January 2012

Chemical profiling of the major components in natural waxes to elucidate their role in liquid oil structuring.

scientific article published on 21 July 2016

Chip-Based Multicapillary Column with Maximal Interconnectivity to Combine Maximum Efficiency and Maximum Loadability

scientific article published on 10 October 2017

Chiral stationary phase optimized selectivity supercritical fluid chromatography: A strategy for the separation of mixtures of chiral isomers

scientific article published on 08 December 2018

Combining liquid chromatography with multiplexed capillary gel electrophoresis for offline comprehensive analysis of complex oligonucleotide samples

scientific article published on 8 February 2014

Comparative evaluation of ICP sample introduction systems to be used in the metabolite profiling of chlorine-containing pharmaceuticals via HPLC-ICP-MS

scientific article published on 19 February 2018

Comparison between polymerized ionic liquids synthesized using chain-growth and step-growth mechanisms used as stationary phase in gas chromatography.

scientific article published on 4 May 2016

Comparison of the quantitative performance of constant pressure versus constant flow rate gradient elution separations using concentration-sensitive detectors

scientific article published on 12 October 2011

Comprehensive hydrophilic interaction and ion-pair reversed-phase liquid chromatography for analysis of di- to deca-oligonucleotides

scientific article published on 6 December 2011

Comprehensive two-dimensional liquid chromatography coupled to the ABTS radical scavenging assay: a powerful method for the analysis of phenolic antioxidants.

scientific article published on 11 May 2014

Construction of a new interface for comprehensive supercritical fluid chromatography x reversed phase liquid chromatography (SFC x RPLC).

scientific article

Deconvolution of overlapping spectral polymer signals in size exclusion separation-diode array detection separations by implementing a multivariate curve resolution method optimized by alternating least square

scientific article published on 27 March 2014

Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography

scientific article

Design and evaluation of various methods for the construction of kinetic performance limit plots for supercritical fluid chromatography

scientific article published on 17 August 2012

Detailed characterisation of the flow resistance of commercial sub-2 micrometer reversed-phase columns

scientific article published on 4 December 2007

Determination of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by solid phase extraction on silica and liquid chromatography-triple quadrupole mass spectrometry

scientific article

Determination of in Vitro and in Silico Indexes for the Modeling of Blood-Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography.

scientific article

Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS).

scientific article

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

scientific article published on 13 December 2011

Effect of analyte properties on the kinetic performance of liquid chromatographic separations

scientific article

Effects of the water-soluble fraction of a crude oil on estuarine meiofauna: A microcosm approach

scientific article published on 25 April 2019

Elution behavior of short dsDNA strands in silicon micropillar array columns in ion pair reversed-phase chromatography mode

scientific article published on 5 September 2012

Enantioseparation of pharmaceutical compounds by multiplexed capillary electrophoresis using highly sulphated alpha-, beta- and gamma-cyclodextrins

scientific article published in November 2008

Enhancing the Possibilities of Comprehensive Two-Dimensional Liquid Chromatography through Hyphenation of Purely Aqueous Temperature-Responsive and Reversed-Phase Liquid Chromatography.

scientific article published on 18 March 2018

Errors involved in the existing B-term expressions for the longitudinal diffusion in fully porous chromatographic media Part II: experimental data in packed columns and surface diffusion measurements.

scientific article

Evaluation of a molecularly imprinted polymer as in-line concentrator in capillary electrophoresis.

scientific article

Evaluation of a multiarray system for pharmaceutical analysis by microemulsion electrokinetic chromatography

scientific article

Evaluation of automated sample preparation, retention time locked gas chromatography-mass spectrometry and data analysis methods for the metabolomic study of Arabidopsis species

scientific article

Evaluation of ionic liquid stationary phases for one dimensional gas chromatography-mass spectrometry and comprehensive two dimensional gas chromatographic analyses of fatty acids in marine biota

scientific article published on 13 March 2011

Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier.

scientific article published on 16 August 2014

Evaluation of the Temperature Responsive Stationary Phase Poly(N-isopropylacrylamide) in Aqueous LC for the Analysis of Small Molecules

article by Frédéric Lynen et al published 19 June 2007 in Chromatographia

Gradient stationary phase optimized selectivity liquid chromatography with conventional columns.

scientific article published in May 2013

High efficiency liquid chromatography on conventional columns and instrumentation by using temperature as a variable. Kinetic plots and experimental verification.

scientific article

High performance liquid chromatography analysis of wine anthocyanins revisited: effect of particle size and temperature.

scientific article published on 21 February 2009

High-efficiency high performance liquid chromatographic analysis of red wine anthocyanins

scientific article published on 18 May 2011

High-efficiency hydrophilic interaction chromatography by coupling 25 cm x 4.6mm ID x 5 microm silica columns and operation at 80 degrees C.

scientific article published on 3 December 2009

Hyphenation of a Deoxyribonuclease I immobilized enzyme reactor with liquid chromatography for the online stability evaluation of oligonucleotides

scientific article published on 26 October 2015

Implementing stationary-phase optimized selectivity in supercritical fluid chromatography

scientific article published in December 2014

Improving the universal response of evaporative light scattering detection by mobile phase compensation

scientific article published on 31 May 2007

In vitro prediction of human intestinal absorption and blood-brain barrier partitioning: development of a lipid analog for micellar liquid chromatography

scientific article published on 16 August 2015

Investigation of poly(styrene-divinylbenzene-vinylsulfonic acid) as retentive and electroosmotic flow generating phase in open-tubular electrochromatography

scientific article published on 23 May 2015

Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions.

scientific article published on 5 March 2009

Kinetic performance evaluation and perspectives of contemporary packed column capillary electrochromatography

scientific article

Kinetic plot and particle size distribution analysis to discuss the performance limits of sub-2 microm and supra-2 microm particle columns.

scientific article published on 9 July 2008

Kinetic plot method as a tool to design coupled column systems producing 100,000 theoretical plates in the shortest possible time.

scientific article

Kinetic plots for gas chromatography: theory and experimental verification.

scientific article published on 23 January 2015

Kinetic plots for programmed temperature gas chromatography.

scientific article

Migration of photoinitiators from cardboard into dry food: evaluation of Tenax® as a food simulant.

scientific article published on 5 May 2016

Mn-salen@MIL101(Al): a heterogeneous, enantioselective catalyst synthesized using a 'bottle around the ship' approach

scientific article published in August 2013

Model-based determination of the influence of textile fabric on bioassay analysis and the effectiveness of a textile slow-release system of DEET in mosquito control

scientific article published on 15 October 2014

Near-infrared luminescence and RNA cleavage ability of lanthanide Schiff base complexes derived from N,N'-bis(3-methoxysalicylidene)ethylene-1,2-diamine ligands

scientific article published on 5 August 2016

Nontargeted Pattern Recognition in the Search for Pyrolysis Gas Chromatography/Mass Spectrometry Resin Markers in Historic Lacquered Objects

scientific article published on 22 May 2019

Nontargeted quantitation of lipid classes using hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry with single internal standard and response factor approach

scientific article published in November 2012

Offline comprehensive liquid chromatography in combination with a Deoxyribonuclease I immobilized enzymatic reactor for selective screening of oligonucleotide mixtures

scientific article published on 6 May 2016

On-column sample enrichment for the high-sensitivity sheath-flow CE-MS analysis of peptides

scientific article published on 10 May 2006

Optimization of a high-resolution radical scavenging assay coupled on-line to reversed-phase liquid chromatography for antioxidant detection in complex natural extracts

scientific article published on 27 January 2015

Performance evaluation of long monolithic silica capillary columns in gradient liquid chromatography using peptide mixtures

scientific article published on 15 October 2010

Pharmaceutical impurity analysis by comprehensive two-dimensional temperature responsive × reversed phase liquid chromatography

scientific article published on 18 September 2020

Predicting drug penetration across the blood-brain barrier: comparison of micellar liquid chromatography and immobilized artificial membrane liquid chromatography.

scientific article published on 30 May 2013

Quantification aspects of constant pressure (ultra) high pressure liquid chromatography using mass-sensitive detectors with a nebulizing interface

scientific article published on 16 December 2012

Quantification of silanol sites for the most common mesoporous ordered silicas and organosilicas: total versus accessible silanols

scientific article published on 27 November 2012

Quantitation of triacylglycerols from plant oils using charged aerosol detection with gradient compensation

scientific article

Removal of atrazine in water by combination of activated carbon and dielectric barrier discharge.

scientific article

Response to Tsikas et al. Comments on Boelaert et al. Determination of Asymmetric and Symmetric Dimethylarginine in Serum from Patients with Chronic Kidney Disease: UPLC-MS/MS versus ELISA. Toxins 2016, 8, 149.

scientific article published on 27 October 2016

Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry.

scientific article published on 7 February 2018

Selectivity optimization in green chromatography by gradient stationary phase optimized selectivity liquid chromatography

scientific article published on 17 September 2010

Serial coupling of reversed-phase and hydrophilic interaction liquid chromatography to broaden the elution window for the analysis of pharmaceutical compounds.

scientific article

Solid-phase extraction based on hydrophilic interaction liquid chromatography with acetone as eluent for eliminating matrix effects in the analysis of biological fluids by LC-MS.

scientific article

Stationary-phase optimized selectivity liquid chromatography: development of a linear gradient prediction algorithm

scientific article published in March 2010

Stir bar sorptive extraction combined with GC-MS analysis and chemometric methods for the classification of South African Wines according to the volatile composition

scientific article published on 21 May 2008

The kinetic plot method applied to gradient chromatography: theoretical framework and experimental validation.

scientific article

Total pore blocking as an alternative method for the on-column determination of the external porosity of packed and monolithic reversed-phase columns

scientific article published on 27 April 2007

Tryptic digest analysis by comprehensive reversed phasextwo reversed phase liquid chromatography (RP-LCx2RP-LC) at different pH's.

scientific article published in April 2009

Tunable temperature responsive liquid chromatography through thiolactone-based immobilization of poly(N-isopropylacrylamide).

scientific article

Turbulence as a source of excessive baseline noise during high-speed isocratic and gradient separations using absorption detection.

scientific article published on 31 January 2008

Universal response in liquid chromatography using charged aerosol detection.

scientific article published in May 2006

Variable column length method development strategy for amino acid analysis in serum samples of neonates with metabolic disorders.

scientific article published on 26 March 2013

Variation in volatile leaf oils of five Eucalyptus species harvested from Jbel Abderrahman arboreta (Tunisia).

scientific article

Wounding stress causes rapid increase in concentration of the naturally occurring 2',3'-isomers of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in plant tissues

scientific article published on 12 April 2014

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