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List of works by Filippo Minutolo

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

scientific article

4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor

scientific article published in October 2002

7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.

scientific article published in December 2001

A Polymer-Supported Phosphazine as a Stable and Practical Reagent in the Three-Component Synthesis of Substituted (Cyclopentadienyl)tricarbonylrhenium Complexes

scientific article published on 01 June 1999

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

scientific article

A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).

scientific article

An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade

scientific article published on 09 October 2018

An update on therapeutic opportunities offered by cancer glycolytic metabolism

scientific article published on 20 September 2014

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

scientific article published on 21 October 2020

Anomalous Face-Selectivity in Sharpless Asymmetric Dihydroxylation of o-Allylbenzamides

scientific article published on 01 June 1996

Anticancer Agents That Counteract Tumor Glycolysis ⬇️

scientific article published on June 8, 2012

Anticancer agents interacting with membrane glucose transporters

scientific article published on 8 July 2016

Antiproliferative activity and cell cycle analysis of 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole on MCF-7 breast and HCT-15 colon cancer cell lines

scientific article published on 25 March 2011

Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties

scientific article published on July 2002

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

scientific article published on 29 August 2013

Asymmetric Synthesis of the Dihydroisocoumarin Moiety of AI-77-B via Copper-Mediated Cross-Coupling and Sharpless Asymmetric Dihydroxylation

scientific article published on 01 May 1996

BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides

scientific article published on 18 September 2010

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

scientific article

Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours

scientific article

CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

scientific article

Carbazole-containing arylcarboxamides as BACE1 inhibitors

scientific article published on 21 September 2011

Ceramide analogues in apoptosis: a new strategy for anticancer drug development.

scientific article

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

scientific article

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 01 December 2019

Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.

scientific article published in January 2003

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

scientific article published on 10 July 2017

Correction to Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

scientific article

Crystallographic evidence for the electronic distribution in (2,4-cyclopentadien-1-yl-idenehydrazono)triphenylphosphorane

scientific article published on 01 June 1999

Curaxins: a new family of non-genotoxic multitargeted anticancer agents.

scientific article

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.

scientific article published on 2 May 2016

Design, Synthesis, and Evaluation of GLUT Inhibitors.

scientific article published in January 2018

Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues

scientific article published in November 2001

Development and validation of a docking-based virtual screening platform for the identification of new lactate dehydrogenase inhibitors.

scientific article published on 15 May 2015

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

scientific article

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

scientific article

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

scientific article

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

scientific article published on 26 December 2020

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

scientific article published on 18 February 2011

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

scientific article published on 25 May 2020

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 16 August 2018

Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

scientific article published on 31 October 2013

Estrogen receptor ligands: a patent review update

scientific article

Estrogen receptor β ligands: recent advances and biomedical applications.

scientific article

Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.

scientific article

Evaluation of the NO-releasing properties of NO-donor linkers

scientific article published in February 2008

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

scientific article published on 16 January 2019

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

scientific article published on 20 February 2019

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

scientific article

Identification and characterization of a new reversible MAGL inhibitor

scientific article

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

scientific article published on 12 May 2014

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

scientific article

Immune by Heart: Unexpected Observations Inspiring Perspective Therapeutic/Preventive Strategies against Cancer

scientific article published on 7 November 2016

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer

scientific article published on 08 May 2018

Metabolically labile cannabinoid esters: A ‘soft drug’ approach for the development of cannabinoid-based therapeutic drugs

scientific article published on 20 June 2007

Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta

scientific article published on 13 February 2008

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

scientific article published on 8 September 2011

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs

scientific article published in November 2004

New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

scientific article published on 01 December 2006

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).

scientific article published on May 2004

New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor

scientific article

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design, Synthesis, and Biopharmacological Properties

scientific article published on 01 April 2006

Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process

scientific article published in September 2003

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

scientific article published on 11 February 2019

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

scientific article published on 28 September 2013

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.

scientific article published on 15 April 2015

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

scientific article published in November 2004

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design

scientific article published on 12 April 2009

Rational Development of MAGL Inhibitors

scientific article published on 01 January 2018

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

scientific article published on 29 September 2014

Risks and benefits related to alimentary exposure to xenoestrogens

scientific article

Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.

scientific article

Salicylaldoxime moiety as a phenolic "A-Ring" substitute in estrogen receptor ligands.

scientific article published in November 2001

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

scientific article published on September 2015

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

scientific article

Small-molecule inhibitors of human LDH5.

scientific article published on October 2013

Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel

scientific article

Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.

scientific article

Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

scientific article published in November 2004

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

scientific article published on 3 November 2016

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

scientific article

Study of apoptosis induction and deoxycytidine kinase/cytidine deaminase modulation in the synergistic interaction of a novel ceramide analog and gemcitabine in pancreatic cancer cells.

scientific article published on June 2010

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

scientific article published on 31 October 2013

Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

scientific article published on 28 September 2019

Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs

scientific article published in January 2004

Synthesis and antiviral properties of 9-[(2-methyleneaminoxyethoxy)methyl]guanine derivatives as novel Acyclovir analogues

scientific article

Synthesis and antiviral properties of novel analogues of monophosphate and diphosphate bioactive forms of acyclovir.

scientific article published in April 2000

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

scientific article published in January 2015

Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand.

scientific article

Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes

scientific article published on 01 August 2006

Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

scientific article published on 01 February 2006

Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells

scientific article published on November 2005

Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity

scientific article published in December 2003

Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring

scientific article published on February 2003

Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties

scientific article published on 2 August 2010

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

scientific article published on 17 October 2011

Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-substituted 3,4-diarylsalicylaldoximes on estrogen receptors alpha and beta

scientific article published in April 2003

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

scientific article published on 21 August 2019

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

scientific article published on 13 December 2017

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.

scientific article published on May 2005

alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors

scientific article

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