List of works - Carlotta Granchi

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

scientific article

A Guide to PIN1 Function and Mutations Across Cancers

scientific article published on 01 January 2018

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

scientific article

A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).

scientific article

ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism

scientific article published on 01 September 2018

Activators of Sirtuin-1 and their Involvement in Cardioprotection

scientific article published on 13 February 2018

An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade

scientific article published on 09 October 2018

An update on therapeutic opportunities offered by cancer glycolytic metabolism

scientific article published on 20 September 2014

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

scientific article published on 21 October 2020

Anticancer Agents That Counteract Tumor Glycolysis ⬇️

scientific article published on June 8, 2012

Anticancer agents interacting with membrane glucose transporters

scientific article published on 8 July 2016

Application of MM-PBSA Methods in Virtual Screening

scientific article published on 23 April 2020

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

scientific article published on 29 August 2013

BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides

scientific article published on 18 September 2010

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

scientific article

Bioactive heterocycles containing endocyclic N-hydroxy groups

scientific article

Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours

scientific article

Biphenyl-Derivatives Possessing Tertiary Amino Groups as β-Secretase (BACE1) Inhibitors

scholarly article by Simone Bertini et al published 1 August 2010 in Letters in drug design & discovery

Carbazole-containing arylcarboxamides as BACE1 inhibitors

scientific article published on 21 September 2011

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

scientific article

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 01 December 2019

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

scientific article published on 10 July 2017

Correction to Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

scientific article

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.

scientific article published on 2 May 2016

Design, Synthesis, and Evaluation of GLUT Inhibitors.

scientific article published in January 2018

Development and validation of a docking-based virtual screening platform for the identification of new lactate dehydrogenase inhibitors.

scientific article published on 15 May 2015

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

scientific article

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

scientific article

Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase

scientific article published on 06 May 2019

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

scientific article published on 26 December 2020

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

scientific article published on 18 February 2011

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

scientific article published on 25 May 2020

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 16 August 2018

Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

scientific article published on 31 October 2013

Effect of Tumor Relevant Acidic Environment in the Interaction of a N-hydroxyindole-2-Carboxylic Derivative with the Phospholipid Bilayer

scientific article published on 09 July 2018

Estrogen receptor ligands: a patent review update

scientific article

Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.

scientific article

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

scientific article published on 16 January 2019

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

scientific article published on 20 February 2019

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

scientific article

Identification and characterization of a new reversible MAGL inhibitor

scientific article

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

scientific article published on 12 May 2014

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

scientific article

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

scientific article published on 30 August 2018

Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials

scientific article published on January 2010

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

scientific article

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer

scientific article published on 08 May 2018

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

scientific article published on 8 September 2011

New Phenylethanoid Glycosides from Cistanche phelypaea and Their Activity as Inhibitors of Monoacylglycerol Lipase (MAGL).

scientific article published on 10 January 2018

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

scientific article published on 18 September 2018

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

scientific article published on 11 February 2019

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

scientific article published on 28 September 2013

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.

scientific article published on 15 April 2015

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

scientific article published on 06 January 2017

Rational Development of MAGL Inhibitors

scientific article published on 01 January 2018

Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death

scientific article published on 27 March 2017

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

scientific article published on 29 September 2014

Risks and benefits related to alimentary exposure to xenoestrogens

scientific article

Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.

scientific article

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

scientific article published on September 2015

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

scientific article

Small-molecule inhibitors of human LDH5.

scientific article published on October 2013

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

scientific article published on 3 November 2016

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

scientific article

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

scientific article published on 31 October 2013

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

scientific article published on 28 September 2019

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

scientific article published in January 2015

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

scientific article published on 17 October 2011

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

scientific article published on 21 August 2019

The influence of Echinacea purpurea leaf microbiota on chicoric acid level

scientific article published on 26 July 2019

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

scientific article published on 13 December 2017

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects

scientific article published on 29 January 2019

alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors

scientific article

List of works by Carlotta Granchi

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

A Guide to PIN1 Function and Mutations Across Cancers

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).

ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism

Activators of Sirtuin-1 and their Involvement in Cardioprotection

An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade

An update on therapeutic opportunities offered by cancer glycolytic metabolism

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

Anticancer Agents That Counteract Tumor Glycolysis ⬇️

Anticancer agents interacting with membrane glucose transporters

Application of MM-PBSA Methods in Virtual Screening

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

Bioactive heterocycles containing endocyclic N-hydroxy groups

Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours

Biphenyl-Derivatives Possessing Tertiary Amino Groups as β-Secretase (BACE1) Inhibitors

Carbazole-containing arylcarboxamides as BACE1 inhibitors

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

Correction to Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.

Design, Synthesis, and Evaluation of GLUT Inhibitors.

Development and validation of a docking-based virtual screening platform for the identification of new lactate dehydrogenase inhibitors.

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

Effect of Tumor Relevant Acidic Environment in the Interaction of a N-hydroxyindole-2-Carboxylic Derivative with the Phospholipid Bilayer

Estrogen receptor ligands: a patent review update

Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

Identification and characterization of a new reversible MAGL inhibitor

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

New Phenylethanoid Glycosides from Cistanche phelypaea and Their Activity as Inhibitors of Monoacylglycerol Lipase (MAGL).

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Rational Development of MAGL Inhibitors

Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

Risks and benefits related to alimentary exposure to xenoestrogens

Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

Small-molecule inhibitors of human LDH5.

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

The influence of Echinacea purpurea leaf microbiota on chicoric acid level

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects

alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors