List of works - Nikolaus Schultz

18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers

scientific article

3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

scientific article published on 23 January 2017

53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma

scientific article published on 21 August 2012

A Multi-Method Approach for Proteomic Network Inference in 11 Human Cancers

scientific article

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

scientific article

ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer

scientific article published on 12 January 2017

Abstract 2608: Global integration of knowledgebases for clinical interpretation of cancer variants

Accelerating Discovery of Functional Mutant Alleles in Cancer

scientific article published on 15 December 2017

Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network

scientific article

An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma

scientific article

Analysis of microRNA-target interactions across diverse cancer types

scientific article

Analytic and clinical validation of a prostate cancer-enhanced messenger RNA detection assay in whole blood as a prognostic biomarker for survival

scientific article published on 26 July 2013

Automated network analysis identifies core pathways in glioblastoma

scientific article

BRCA1 immunohistochemistry in a molecularly characterized cohort of ovarian high-grade serous carcinomas

scientific article

BridgeDb app: unifying identifier mapping services for Cytoscape

scientific article published on July 2014

Cancer cells preferentially lose small chromosomes

scientific article published on 26 November 2012

Chemotherapy Resistance in Diffuse-Type Gastric Adenocarcinoma Is Mediated by RhoA Activation in Cancer Stem-Like Cells

scientific article published on 19 October 2015

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

scientific article

Clinical and molecular characterization of patients with cancer of unknown primary in the modern era.

scientific article

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma

scientific article

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

scientific article published on September 2014

Collection, integration and analysis of cancer genomic profiles: from data to insight

scientific article

Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver.

scientific article published on 10 September 2012

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

article

Comprehensive analysis of long non-coding RNAs in ovarian cancer reveals global patterns and targeted DNA amplification

scientific article

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

scientific article

Copy number alteration burden predicts prostate cancer relapse

scientific article published on 14 July 2014

Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors

scientific article published on 12 September 2012

ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis

scientific article published on 14 June 2017

Emerging landscape of oncogenic signatures across human cancers

scientific article

Evaluating cell lines as tumour models by comparison of genomic profiles

scientific article published on January 2013

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

scientific article

Expression of the Carboxy-Terminal Portion of MUC16/CA125 Induces Transformation and Tumor Invasion

scientific article (publication date: 2015)

Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas

scientific article published on December 2011

G2S: A web-service for annotating genomic variants on 3D protein structures

scientific article published on 27 January 2018

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors

scientific article

Genome Nexus: A Comprehensive Resource for the Annotation and Interpretation of Genomic Variants in Cancer

scientific article published in 2022

Genome-wide analysis of noncoding regulatory mutations in cancer

scientific article published on 28 September 2014

Genomic Characterization of Upper Tract Urothelial Carcinoma

scientific article

Genomic Differences Between "Primary" and "Secondary" Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy

scientific article published on 02 October 2018

Genomic complexity and AKT dependence in serous ovarian cancer

scientific article published on January 2012

Genomic correlates of clinical outcome in advanced prostate cancer.

scientific article

Genomic predictors of survival in patients with high-grade urothelial carcinoma of the bladder

scientific article

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

scientific article

Identification of low abundance microbiome in clinical samples using whole genome sequencing

scientific article published on 27 November 2015

Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling

scientific article

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

scientific article

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

scientific article published on 06 July 2016

Integrated Molecular Characterization of Testicular Germ Cell Tumors

article by Hui Shen et al published 12 June 2018 in Cell Reports

Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma

scientific article (publication date: 2012)

Integrated genomic characterization of endometrial carcinoma ⬇️

scientific article published on May 2, 2013

Integrating biological pathways and genomic profiles with ChiBE 2.

scientific article

Integrative Clinical Genomics of Advanced Prostate Cancer

scientific article

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

scientific article

Integrative clinical genomics of advanced prostate cancer

scientific article

Integrative genome-wide analysis of the determinants of RNA splicing in kidney renal clear cell carcinoma

scientific article published on January 2015

Integrative genomic profiling of human prostate cancer

scientific article (publication date: 13 July 2010)

Integrative subtype discovery in glioblastoma using iCluster

scientific article

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

scientific article

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

scientific journal article

MEF promotes stemness in the pathogenesis of gliomas

scientific article published on December 2012

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes

scientific article published on January 2013

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia

scientific article

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

scientific article published in April 2018

Mitochondrial respiratory gene expression is suppressed in many cancers

scientific article published on 18 January 2017

Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand (PD-L)-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing

scientific article published on 16 January 2018

Molecular subtypes of uterine leiomyosarcoma and correlation with clinical outcome

scientific article

Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications

scientific article published on 16 December 2016

Multicenter Phase II Study of Temozolomide and Myeloablative Chemotherapy with Autologous Stem Cell Transplant for Newly Diagnosed Anaplastic Oligodendroglioma

scientific article published on 2 May 2017

Multiplexed immunofluorescence delineates proteomic cancer cell states associated with metabolism

scientific article published on May 2016

MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer

scientific article

Mutual exclusivity analysis identifies oncogenic network modules

scientific article published on 9 September 2011

Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets

scientific article published on 2 June 2017

Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

scientific article (publication date: 14 March 2011)

Oncogenic Signaling Pathways in The Cancer Genome Atlas

scientific article published in April 2018

Oncologist use and perception of large panel next-generation tumor sequencing

scientific article published on September 2017

PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer

scientific article published on 05 January 2015

Pan-Cancer Analysis of Mutation Hotspots in Protein Domains

scientific article published on 23 September 2015

Pathway Commons, a web resource for biological pathway data

scientific article

PathwayMapper: a collaborative visual web editor for cancer pathways and genomic data

scientific article published in July 2017

Pattern discovery and cancer gene identification in integrated cancer genomic data

scientific article

Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles

scientific article

Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer

scientific article published on 29 July 2013

Publisher Correction: The long tail of oncogenic drivers in prostate cancer

scientific article published on 01 July 2019

Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype

scientific article published on 28 July 2017

Recurrent SMARCA4 mutations in small cell carcinoma of the ovary.

scientific article

Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping

scientific article

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer

scientific article published on December 2013

Small cell carcinomas of the bladder and lung are characterized by a convergent but distinct pathogenesis

scientific article published on 27 November 2017

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

scientific article published on 29 November 2009

Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer

scientific article published on 29 February 2016

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy

scientific article published on 16 June 2014

Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

scientific article

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma

scientific article published on 22 February 2018

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

scientific article

The long tail of oncogenic drivers in prostate cancer.

scientific article published on 2 April 2018

The molecular diversity of Luminal A breast tumors

scientific article published on 06 October 2013

The mutational landscape of adenoid cystic carcinoma

scientific article published on 19 May 2013

The performance of BRCA1 immunohistochemistry for detecting germline, somatic, and epigenetic BRCA1 loss in high-grade serous ovarian cancer

scientific article

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

scientific journal article

Time to recurrence and survival in serous ovarian tumors predicted from integrated genomic profiles

scientific article

Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy

scientific article

Unifying cancer and normal RNA sequencing data from different sources

scientific article published on 17 April 2018

Using MEMo to discover mutual exclusivity modules in cancer

scientific article published on March 2013

Will kinase inhibitors make it as glioblastoma drugs?

scientific article

List of works by Nikolaus Schultz

18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers

3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma

A Multi-Method Approach for Proteomic Network Inference in 11 Human Cancers

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer

Abstract 2608: Global integration of knowledgebases for clinical interpretation of cancer variants

Accelerating Discovery of Functional Mutant Alleles in Cancer

Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network

An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma

Analysis of microRNA-target interactions across diverse cancer types

Analytic and clinical validation of a prostate cancer-enhanced messenger RNA detection assay in whole blood as a prognostic biomarker for survival

Automated network analysis identifies core pathways in glioblastoma

BRCA1 immunohistochemistry in a molecularly characterized cohort of ovarian high-grade serous carcinomas

BridgeDb app: unifying identifier mapping services for Cytoscape

Cancer cells preferentially lose small chromosomes

Chemotherapy Resistance in Diffuse-Type Gastric Adenocarcinoma Is Mediated by RhoA Activation in Cancer Stem-Like Cells

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

Clinical and molecular characterization of patients with cancer of unknown primary in the modern era.

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

Collection, integration and analysis of cancer genomic profiles: from data to insight

Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver.

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

Comprehensive Characterization of Cancer Driver Genes and Mutations

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

Comprehensive analysis of long non-coding RNAs in ovarian cancer reveals global patterns and targeted DNA amplification

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Copy number alteration burden predicts prostate cancer relapse

Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors

ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis

Emerging landscape of oncogenic signatures across human cancers

Evaluating cell lines as tumour models by comparison of genomic profiles

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

Expression of the Carboxy-Terminal Portion of MUC16/CA125 Induces Transformation and Tumor Invasion

Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas

G2S: A web-service for annotating genomic variants on 3D protein structures

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors

Genome Nexus: A Comprehensive Resource for the Annotation and Interpretation of Genomic Variants in Cancer

Genome-wide analysis of noncoding regulatory mutations in cancer

Genomic Characterization of Upper Tract Urothelial Carcinoma

Genomic Differences Between "Primary" and "Secondary" Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy

Genomic complexity and AKT dependence in serous ovarian cancer

Genomic correlates of clinical outcome in advanced prostate cancer.

Genomic predictors of survival in patients with high-grade urothelial carcinoma of the bladder

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

Identification of low abundance microbiome in clinical samples using whole genome sequencing

Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

Integrated Molecular Characterization of Testicular Germ Cell Tumors

Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma

Integrated genomic characterization of endometrial carcinoma ⬇️

Integrating biological pathways and genomic profiles with ChiBE 2.

Integrative Clinical Genomics of Advanced Prostate Cancer

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

Integrative clinical genomics of advanced prostate cancer

Integrative genome-wide analysis of the determinants of RNA splicing in kidney renal clear cell carcinoma

Integrative genomic profiling of human prostate cancer

Integrative subtype discovery in glioblastoma using iCluster

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

MEF promotes stemness in the pathogenesis of gliomas

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

Mitochondrial respiratory gene expression is suppressed in many cancers

Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand (PD-L)-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing

Molecular subtypes of uterine leiomyosarcoma and correlation with clinical outcome

Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications

Multicenter Phase II Study of Temozolomide and Myeloablative Chemotherapy with Autologous Stem Cell Transplant for Newly Diagnosed Anaplastic Oligodendroglioma

Multiplexed immunofluorescence delineates proteomic cancer cell states associated with metabolism

MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer

Mutual exclusivity analysis identifies oncogenic network modules

Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets

Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Oncologist use and perception of large panel next-generation tumor sequencing

PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer