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List of works by Kevin Docherty

35th Annual Meeting of the European Association for the Study of Diabetes

article

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

A RIPE3b1-like factor binds to a novel site in the human insulin promoter in a redox-dependent manner

scientific article published on 01 November 1997

A comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones

scientific article published on 18 July 2013

A comparison of the effects of bromocriptine and somatostatin on growth hormone gene expression in the rat anterior pituitary gland in vitro

scientific article published in August 1987

A consensus repeat sequence from the human insulin gene linked polymorphic region adopts multiple quadriplex DNA structures in vitro

scientific article published on 01 April 1992

A factor(s) secreted from MIN-6 beta-cells stimulates differentiation of definitive endoderm enriched embryonic stem cells towards a pancreatic lineage

scientific article published on 30 July 2010

A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase ⬇️

scientific article published on July 15, 1992

A new series of CAT expression vectors

scientific article published on December 1989

A silencer and an adjacent positive element interact to modulate the activity of the human insulin promoter

scientific article

ATF-2 stimulates the human insulin promoter through the conserved CRE2 sequence

scientific article

An engineered zinc finger protein reveals a role for the insulin VNTR in the regulation of the insulin and adjacent IGF2 genes

scientific article

Association of prohormone convertase 3 with membrane lipid rafts.

scientific article published on August 2001

Autocatalytic maturation of the prohormone convertase PC2.

scientific article published in January 1994

Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells

scientific article

C/EBPbeta reprograms white 3T3-L1 preadipocytes to a Brown adipocyte pattern of gene expression

scientific article published on 21 June 2007

Calcium- and pH-dependent aggregation and membrane association of the precursor of the prohormone convertase PC2

scientific article

Carboxypeptidase activity in the insulin secretory granule

scientific article published on 01 October 1983

Cell therapy for type 1 diabetes

scientific article published on 29 January 2014

Characterization of PC2, a mammalian Kex2 homologue, following expression of the cDNA in microinjected Xenopus oocytes

scientific article published in June 1991

Combinatorial transcription factor regulation of the cyclic AMP-response element on the Pgc-1alpha promoter in white 3T3-L1 and brown HIB-1B preadipocytes

scientific article published on 02 June 2009

Comparative analysis of insulin gene promoters: implications for diabetes research

scientific article published on December 2006

Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease

scientific article

Cyclic AMP produces desensitization of prostacyclin and adenosine A2 receptors in hybrid cell lines but does not affect Gs function

scientific article published on March 1992

Demonstration of thyrotrophin beta-subunit messenger RNA in rat pituitary cells in primary culture--evidence for regulation by thyrotrophin-releasing hormone and forskolin

scientific article

Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2

scientific article

Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events

scientific article published in January 1995

Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2 ⬇️

scientific article published on September 15, 1998

Effect of hypothyroidism on pituitary cytoplasmic concentrations of messenger RNA encoding thyrotrophin beta and alpha subunits, prolactin and growth hormone

scientific article published in January 1986

Effects of 7B2 on the maturation of pro-hormone convertase 2 (PC2) in vitro

scientific article published in May 1996

Efficient differentiation of AR42J cells towards insulin-producing cells using pancreatic transcription factors in combination with growth factors ⬇️

scientific article published on March 10, 2012

Embryonic stem cell therapy for diabetes mellitus

scientific article published on 11 September 2007

Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy

scientific article

Enhanced expression of a furin-cleavable proinsulin

scientific article

Evidence for facilitated diffusion of sugars in rat liver lysosomes [proceedings]

scientific article published on April 1979

Evidence for recognition of novel islet T cell antigens by granule-specific T cell lines from new onset type 1 diabetic patients

scientific article published on July 2000

Expression of GLUT2 in insulin-secreting AtT20 pituitary cells

scientific article

Expression of normal and mutant human pre-pro-insulins in Xenopus oocytes

scientific article published on 01 January 1988

Gamma-aminobutyric acid up-regulates the expression of a novel secretogranin-II messenger ribonucleic acid in the goldfish pituitary

scientific article

Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site

scientific article

Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner

scientific article published on October 1994

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

scientific article published on March 2000

Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner

scientific article

Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells

scientific article published on January 1999

Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus ⬇️

scientific article published on December 1, 2001

Hormonal regulation of thyrotrophin synthesis and secretion.

scientific article published in January 1987

Human insulin gene enhancer-binding proteins in pancreatic alpha and beta cell lines.

scientific article

Identification and characterization of a functional retinoic acid/thyroid hormone-response element upstream of the human insulin gene enhancer ⬇️

scientific article published on August 1, 1995

Identification of a 31,500 molecular weight islet cell protease as cathepsin B ⬇️

scientific article published on June 1, 1983

Identification of adjacent binding sites for the YY1 and E4BP4 transcription factors in the ovine PrP (Prion) gene promoter.

scientific article published on 07 January 2009

Impaired expression of transcription factor IUF1 in a pancreatic β‐cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis) ⬇️

scientific article published on August 18, 1997

Increased vimentin in human α- and β-cells in type 2 diabetes

scientific article published on 27 March 2017

Inducible expression of mutant human proinsulins in a mouse pituitary cell line controlled by the mouse metallothionein promotor

scientific article published on April 1991

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells

scientific article

Inhibitory effect of pax4 on the human insulin and islet amyloid polypeptide (IAPP) promoters

scientific journal article

Insulin delivery by somatic cell gene therapy

scientific article published in December 1993

Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family

scientific article published on February 2004

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

scientific article

Insulin-releasing pituitary cells as a model for somatic cell gene therapy in diabetes mellitus

scientific article published on August 1994

Ionic effects on the transport of sugars in rat liver lysosomes [proceedings]

scientific article published on October 1979

Islet transplantation from a nationally funded UK centre reaches socially deprived groups and improves metabolic outcomes

scientific article published on 26 March 2015

Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture

scientific article published on 12 October 2015

Metabolic control of insulin gene expression and biosynthesis ⬇️

scientific article published on December 1, 1991

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

scientific article

Modulation by oestrogen of thyroid hormone effects on thyrotrophin gene expression

scientific article published in October 1987

Molecular forms of cathepsin B in rat thyroid cells (FRTL5): comparison with molecular forms in liver (Hep G2) and insulin-secreting cells (HIT T15)

scientific article published on 01 February 1988

Mutations within the propeptide, the primary cleavage site or the catalytic site, or deletion of C-terminal sequences, prevents secretion of proPC2 from transfected COS-7 cells

scientific article

Nutrient regulation of insulin gene expression.

scientific article published on January 1994

Palmitate enhances the differentiation of mouse embryonic stem cells towards white adipocyte lineages

scientific article

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.

scientific article

Pancreatic stellate cells can form new beta-like cells.

scientific article published on 26 June 2009

Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell

scientific article published on 22 July 2008

Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreas

scientific article

Permeability properties of lysosomal membranes

scientific article published on March 1983

Positive and negative regulation of the human insulin gene by multiple trans-acting factors

scientific article published on May 1990

Presence of endocrine and exocrine markers in EGFP-positive cells from the developing pancreas of a nestin/EGFP mouse

scientific article

Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2

scientific article published on 01 January 1996

Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.

scientific article

Proglucagon expression, posttranslational processing and secretion in SV40-transformed islet cells

scientific article published on 01 November 1989

Prospects for insulin delivery by ex-vivo somatic cell gene therapy

scientific article published in January 1999

Regulation of insulin gene transcription by nutrients

scientific article

Relative contribution of PDX-1, MafA and E47/beta2 to the regulation of the human insulin promoter

scientific article

Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo

scientific article published on March 2002

Sex steroid regulation of glutamate decarboxylase mRNA expression in goldfish brain is sexually dimorphic.

scientific article

Sexually dimorphic expression of glutamate decarboxylase mRNA in the hypothalamus of the deep sea armed grenadier, Coryphaenoides (Nematonurus) armatus

scientific article published in November 2000

Site-directed mutagenesis and expression of PC2 in microinjected Xenopus oocytes ⬇️

scientific article published on December 15, 1991

Sorting of PC2 to the regulated secretory pathway in AtT20 cells ⬇️

scientific article published on October 1, 1998

Stem cells and metabolic diseases

scientific article published on June 2008

Sugar transport in rat liver lysosomes. Direct demonstration by using labelled sugars

scientific article published on April 1983

Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.

scientific article

Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells

scientific article published on 22 April 2013

The effect of water temperature on the GABAergic and reproductive systems in female and male goldfish (Carassius auratus).

scientific article published in February 2002

The effects of ions and pH on the transport of sugars into rat liver lysosomes

scientific article published on October 1979

The gel retardation assay

scientific article published on January 1994

The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer

scientific article published on October 1993

The human insulin gene linked polymorphic region exhibits an altered DNA structure ⬇️

scientific article published on January 25, 1992

The insulin enhancer binding site 2 (IEB2; FAR) box of the insulin gene regulatory region binds at least three factors that can be distinguished by their DNA binding characteristics

scientific article

The insulin gene promoter. A simplified nomenclature

scientific article

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells

scientific article

The permeability of rat liver lysosomes to sugars. Evidence for carrier-mediated facilitated diffusion ⬇️

scientific article published on February 15, 1979

The propeptide of prohormone convertase PC2 acts as a transferable aggregation and membrane-association signal

scientific article published in October 1998

Thyroid status affects the regulation of prolactin mRNA accumulation by tri-iodothyronine and thyrotrophin-releasing hormone in cultured rat anterior pituitary cells

scientific article

Transcription factor cycling on the insulin promoter

scientific article published on 28 December 2005

Two proteins act as the IUF1 insulin gene enhancer binding factor

scientific article

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