List of works - Debby Laukens

A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach

scientific article published on 19 September 2013

Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury

scientific article published on 8 February 2010

Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential

scientific article published on 6 May 2015

Altered gut transcriptome in spondyloarthropathy

scientific article published on 13 February 2006

Association between ASCA-positivity and carrier of a CARD-15 mutation in patients with Crohn's disease.

scientific article published on 24 February 2003

Boosting the hypoxia-induced adaptive response in inflammatory bowel disease: a novel concept of treatment

scientific article

Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

scientific article published on 13 September 2017

CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease

scientific article published on 11 November 2004

CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients

scientific article published in May 2005

CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease

scientific article published in June 2007

Cellular diversity in the colon: another brick in the wall

scientific article published on 01 July 2019

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.

scientific article published in June 2015

Common variants at five new loci associated with early-onset inflammatory bowel disease

scientific article

Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment

scientific article

Detection and Manipulation of the Stress Response Protein Metallothionein

scientific article published on February 2017

Detrimental shifts in microbial communities from inflammatory bowel disease patients upon selective pressures.

scientific article

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls

scientific article

Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease

scientific article

Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?

scientific article published on 27 January 2014

Erratum: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scholarly article published in Nature Genetics

Evidence for a potential role of metallothioneins in inflammatory bowel diseases

scientific article published on 26 August 2009

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis

scientific article published in 2010

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.

scientific article

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease

scientific article published on 20 November 2015

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

scientific article

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

scientific article

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis

scientific article

Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design

scientific article

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

scientific article

Human metallothionein expression under normal and pathological conditions: mechanisms of gene regulation based on in silico promoter analysis

scientific article published on January 2009

Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.

scientific article published on 13 October 2010

Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview.

scientific article

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

scientific article published on 05 December 2018

Interindividual differences in response to treatment with butyrate-producing Butyricicoccus pullicaecorum 25-3T studied in an in vitro gut model

scientific article published on 20 May 2015

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia.

scientific article published on 27 June 2011

Intrarectal nitric oxide administration prevents cellular infiltration but not colonic injury during dextran sodium sulfate colitis

scientific article published on 15 March 2012

Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis

scientific article

Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease?

scientific article

Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using μPET/CT.

scientific article published on 16 December 2010

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scientific journal article

Metallothionein and stress combine to affect multiple organ systems

scientific article

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

scientific article

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma.

scientific article published on 7 May 2016

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

scientific article

Novel development in extraintestinal manifestations and spondylarthropathy

scientific article published on April 2011

Oral supplementation with sulodexide inhibits neo-angiogenesis in a rat model of peritoneal perfusion

scientific article published on 12 July 2011

Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake?

scientific article published in January 2013

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

scientific article published on 11 January 2016

Radiological sacroiliitis is linked with CARD15 gene polymorphisms in patients with Crohn's disease.

scientific article published on 24 February 2004

Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's disease

scientific article published on September 2004

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

scientific article

Role of metallothioneins as danger signals in the pathogenesis of colitis

scientific article published on 24 February 2014

Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension

scientific article published on 12 September 2009

Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype

scientific article published on 26 August 2011

T84 monolayers are superior to Caco-2 as a model system of colonocytes.

scientific article published on 6 March 2017

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

scientific article

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

scientific article published on 13 October 2014

The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice

scientific article published on 2 November 2015

The paradox of the unfolded protein response in cancer

scientific article

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent

scientific article

Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor

scientific article published on 19 June 2017

Tumor PD-L1 status and CD8+ tumor-infiltrating T cells: markers of improved prognosis in oropharyngeal cancer

scientific article published on 6 July 2017

Unmet Needs in IBD: the Case of Fatigue.

scientific article published on 29 August 2017

Validated High Resolution Mass Spectrometry-Based Approach for Metabolomic Fingerprinting of the Human Gut Phenotype.

scientific article published on 9 October 2015

List of works by Debby Laukens

A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach

Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury

Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential

Altered gut transcriptome in spondyloarthropathy

Association between ASCA-positivity and carrier of a CARD-15 mutation in patients with Crohn's disease.

Boosting the hypoxia-induced adaptive response in inflammatory bowel disease: a novel concept of treatment

Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease

CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients

CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease

Cellular diversity in the colon: another brick in the wall

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.

Common variants at five new loci associated with early-onset inflammatory bowel disease

Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment

Detection and Manipulation of the Stress Response Protein Metallothionein

Detrimental shifts in microbial communities from inflammatory bowel disease patients upon selective pressures.

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls

Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease

Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?

Erratum: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Evidence for a potential role of metallothioneins in inflammatory bowel diseases

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis

Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Human metallothionein expression under normal and pathological conditions: mechanisms of gene regulation based on in silico promoter analysis

Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.

Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview.

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Interindividual differences in response to treatment with butyrate-producing Butyricicoccus pullicaecorum 25-3T studied in an in vitro gut model

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia.

Intrarectal nitric oxide administration prevents cellular infiltration but not colonic injury during dextran sodium sulfate colitis

Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis

Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease?

Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using μPET/CT.

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Metallothionein and stress combine to affect multiple organ systems

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma.

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

Novel development in extraintestinal manifestations and spondylarthropathy

Oral supplementation with sulodexide inhibits neo-angiogenesis in a rat model of peritoneal perfusion

Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake?

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

Radiological sacroiliitis is linked with CARD15 gene polymorphisms in patients with Crohn's disease.

Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's disease

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

Role of metallothioneins as danger signals in the pathogenesis of colitis

Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension

Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype

T84 monolayers are superior to Caco-2 as a model system of colonocytes.

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice

The paradox of the unfolded protein response in cancer

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent

Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor

Tumor PD-L1 status and CD8+ tumor-infiltrating T cells: markers of improved prognosis in oropharyngeal cancer

Unmet Needs in IBD: the Case of Fatigue.

Validated High Resolution Mass Spectrometry-Based Approach for Metabolomic Fingerprinting of the Human Gut Phenotype.