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List of works by Timothy L. Cover

A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation

scientific article

A Nonoligomerizing Mutant Form of Helicobacter pylori VacA Allows Structural Analysis of the p33 Domain.

scientific article published on 5 July 2016

A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation

scientific article published on 01 December 1999

Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells

scientific article published on 01 July 2000

Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly

scientific article published on August 25, 1997

Alteration of the Helicobacter pylori membrane proteome in response to changes in environmental salt concentration.

scientific article

Alterations in Helicobacter pylori triggered by contact with gastric epithelial cells

scientific article

Amino-terminal hydrophobic region of Helicobacter pylori vacuolating cytotoxin (VacA) mediates transmembrane protein dimerization.

scientific article published on February 2001

An Overview of Helicobacter pylori VacA Toxin Biology

scientific article

An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA

scientific article

Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression

scientific article published on 18 June 2012

Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin

scientific article

Analysis of cagA in Helicobacter pylori strains from Colombian populations with contrasting gastric cancer risk reveals a biomarker for disease severity

scientific article

Analysis of genetic diversity in cytotoxin-producing and non-cytotoxin-producing Helicobacter pylori strains

scientific article published on 01 July 1995

Analysis of hopQ alleles in East Asian and Western strains of Helicobacter pylori

scientific article published in October 2005

Analysis of protein expression regulated by the Helicobacter pylori ArsRS two-component signal transduction system

scientific article

Analysis of surface-exposed outer membrane proteins in Helicobacter pylori.

scientific article

Antibody Responses to Subspecies Proteins in a Large Prospective Colorectal Cancer Cohort Consortium

article

Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer

scientific article published on 30 October 2020

Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts

scientific article

Bacterial Energetic Requirements for Helicobacter pylori Cag Type IV Secretion System-Dependent Alterations in Gastric Epithelial Cells

scientific article published on 22 January 2020

Beta2 integrin mediates entry of a bacterial toxin into T lymphocytes

scientific article published on 01 January 2008

Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin.

scientific article

Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression

scientific article published on 19 November 2018

Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation

scientific article published on 16 September 2003

Characterization of HeLa cell vacuoles induced by Helicobacter pylori broth culture supernatant

scientific article published on 01 September 1992

Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells

scientific article published on 21 August 2003

Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori

scientific article published on 01 January 1997

Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin

scientific article published on 23 January 2004

Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism

scientific article

Comparative genomic analysis of East Asian and non-Asian Helicobacter pylori strains identifies rapidly evolving genes.

scientific article

Control of gene expression in Helicobacter pylori using the Tet repressor

scientific article published on 8 October 2013

Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization

scientific article published on 05 April 2019

Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

scientific article published on 02 September 2020

Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain

scientific article

Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology

scientific article published on 01 September 1996

Determinants of Raft Partitioning of the Helicobacter pylori Pore-Forming Toxin VacA

scientific article published on 23 April 2018

Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration

scientific article published on 12 September 2016

Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children

scientific article published on 09 January 2013

Dynamic Computational Model of Symptomatic Bacteremia to Inform Bacterial Separation Treatment Requirements

scientific article

Effect of environmental salt concentration on the Helicobacter pylori exoproteome

scientific article published on 04 May 2019

Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10.

scientific article

Effects of Helicobacter pylori on intracellular Ca2+ signaling in normal human gastric mucous epithelial cells

scientific article published on 26 February 2003

Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis

scientific article

Epithelial Coculture and l-Lactate Promote Growth of Helicobacter cinaedi under H2-Free Aerobic Conditions

scientific article published on 09 September 2016

Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin

scientific article

Expression of Helicobacter pylori vacuolating toxin in Escherichia coli.

scientific article

Flagellar localization of a Helicobacter pylori autotransporter protein

scientific article published on 9 April 2013

Functional Properties of Oligomeric and Monomeric Forms of Helicobacter pylori VacA Toxin

scientific article published on 20 September 2021

Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin

scientific article published on 29 January 2007

Functional plasticity in the type IV secretion system of Helicobacter pylori

scientific article

Functional properties of Helicobacter pylori VacA toxin m1 and m2 variants

scientific article published on 13 April 2020

Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin.

scientific article

Genes required for assembly of pili associated with the Helicobacter pylori cag type IV secretion system

scientific article

Genetic signatures for Helicobacter pylori strains of West African origin

scientific article published on 29 November 2017

Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer

scientific article

Genome-wide transcriptional profiling in a histidine kinase mutant of Helicobacter pylori identifies members of a regulon

scientific article published on August 2002

Genomic Comparison of cag pathogenicity island (PAI)-positive and -negative Helicobacter pylori strains: identification of novel markers for cag PAI-positive strains

scientific article

Global analysis of Helicobacter pylori gene expression in human gastric mucosa

scientific article

Growth phase regulation of flaA expression in Helicobacter pylori is luxS dependent

scientific article published on September 2004

Growth phase-dependent composition of the Helicobacter pylori exoproteome.

scientific article

Helicobacter pylori Diversity and Gastric Cancer Risk

scientific article

Helicobacter pylori HopQ outer membrane protein attenuates bacterial adherence to gastric epithelial cells.

scientific article

Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells

scientific article published on 14 July 2008

Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells.

scientific article

Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes

scientific article published on 28 April 2008

Helicobacter pylori VacA toxin inhibits human immunodeficiency virus infection of primary human T cells

scientific article

Helicobacter pylori VacA, a paradigm for toxin multifunctionality

scientific article

Helicobacter pylori Vacuolating Toxin and Gastric Cancer.

scientific article published on 12 October 2017

Helicobacter pylori adaptation in vivo in response to a high-salt diet

scientific article

Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy

scientific article published on 12 August 2017

Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells

scientific article

Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface

scientific article

Helicobacter pylori factors associated with disease

scientific article published on 01 July 1999

Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease.

scientific article

Helicobacter pylori in health and disease

scientific article published on 7 May 2009

Helicobacter pylori infection in Japanese patients with adenocarcinoma of the stomach

scientific article published on 01 November 1993

Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses

scientific article

Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells.

scientific article published in April 1998

Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets

scientific article published on 01 October 2007

Heterogeneity among Helicobacter pylori strains in expression of the outer membrane protein BabA.

scientific article

High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis

scientific article published on 8 April 2013

High resolution structural analysis of Helicobacter pylori VacA toxin oligomers by cryo-negative staining electron microscopy

scientific article published on September 2005

High salt conditions alter transcription of Helicobacter pylori genes encoding outer membrane proteins

scientific article published on 11 December 2017

High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori

scientific article published on May 1997

Host response to Helicobacter pylori infection before initiation of the adaptive immune response

scientific article published on 04 October 2007

Human and Helicobacter pylori coevolution shapes the risk of gastric disease

scientific article published on 13 January 2014

Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34.

scientific article published on 17 April 2013

In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription

scientific article

In search of the Helicobacter pylori VacA mechanism of action.

scientific article

Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion

scholarly article

Interactions between p-33 and p-55 Domains of the Helicobacter pylori Vacuolating Cytotoxin (VacA)

scientific article published in Journal of Biological Chemistry

Intercellular communication in Helicobacter pylori: luxS is essential for the production of an extracellular signaling molecule

scientific article

Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability

scientific article published on 25 March 2019

Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans

scientific article

J-Western forms of Helicobacter pylori cagA constitute a distinct phylogenetic group with a widespread geographic distribution

scientific article published on 13 January 2012

L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori

scientific article

Lipoprotein Processing and Sorting in Helicobacter pylori

scientific article published on 19 May 2020

Magnetic Extraction of Acinetobacter baumannii Using Colistin-Functionalized γ-Fe2O3/Au Core/Shell Composite Nanoclusters.

scientific article

Mapping of a domain required for protein-protein interactions and inhibitory activity of a Helicobacter pylori dominant-negative VacA mutant protein.

scientific article published in April 2006

Mimicry of a host anion channel by a Helicobacter pylori pore-forming toxin

scientific article

Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System

scientific article published on 14 May 2019

Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex.

scientific article

Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA

scientific article

Multiple chromosomal loci for the babA gene in Helicobacter pylori

scientific article published on May 2006

Multiple oligomeric states of the Helicobacter pylori vacuolating toxin demonstrated by cryo-electron microscopy

scientific article published on April 2002

Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children

scientific article published in April 2012

Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis

scientific article

PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacoulating activity of Helicobacter pylori VacA toxin

scientific article published on 3 September 2002

Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments.

scientific article published on 18 September 2017

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens

scientific article

Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk

scientific article

Potentiation of Helicobacter pylori vacuolating toxin activity by nicotine and other weak bases

scientific article published on 01 November 1992

Promoter analysis of Helicobacter pylori genes with enhanced expression at low pH.

scientific article

Protein-protein interactions among Helicobacter pylori cag proteins

scientific article

Pseudomonas paucimobilis empyema after cardiac transplantation

scientific article published on 01 June 1988

Quantitative effect of luxS gene inactivation on the fitness of Helicobacter pylori

scientific article

Racial differences in Helicobacter pylori CagA sero-prevalence in a consortium of adult cohorts in the United States

scientific article published on 20 August 2020

Random mutagenesis of Helicobacter pylori vacA to identify amino acids essential for vacuolating cytotoxic activity.

scientific article

Reconstitution of Helicobacter pylori VacA toxin from purified components

scientific article

Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels.

scientific article published in February 2003

Regulation of Helicobacter pylori Virulence Within the Context of Iron Deficiency

scientific article published on 11 December 2014

Regulation of Helicobacter pylori cagA expression in response to salt

scientific article published on 01 May 2007

Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection

scientific article

Requirement of histidine kinases HP0165 and HP1364 for acid resistance in Helicobacter pylori

scientific article published on May 2006

Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin

scientific article published on 30 October 2006

Role of Helicobacter pylori CagL in modulating gastrin expression

scientific article published on 09 March 2012

Role of Helicobacter pylori outer membrane proteins in gastroduodenal disease

scientific article published on 03 October 2006

Role of a Stem-Loop Structure in Helicobacter pylori cagA Transcript Stability

scientific article published on 24 January 2019

Role of connexin 43 in Helicobacter pylori VacA-induced cell death.

scientific article

Serological assays for identification of human gastric colonization by Helicobacter pylori strains expressing VacA m1 or m2.

scientific article published on 31 January 2007

Serological response to Helicobacter pylori proteins associate with risk of colorectal cancer among diverse populations in the United States

article

Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori

scientific article published on September 1, 1992

Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth

scientific article published on 17 November 2006

Structural analysis of the DNA-binding domain of the Helicobacter pylori response regulator ArsR.

scientific article published on 30 December 2008

Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin

scientific article published on 20 November 2012

Structural organization of membrane-inserted hexamers formed by Helicobacter pylori VacA toxin

scientific article published on 16 June 2016

Structure of the Cag type IV secretion system

scientific article published on 18 June 2019

Supporting data for analysis of the Helicobacter pylori exoproteome

scientific article

Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy

scientific article published on August 2004

Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

scientific article published on 30 June 2020

The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration

scientific article

The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay

scientific article

The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.

scientific article

The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments

scientific article

The vacuolating cytotoxin of Helicobacter pylori.

scientific article

The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH.

scientific article

Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T cells

scientific article published on 19 September 2018

Two different families of hopQ alleles in Helicobacter pylori

scientific article

VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent Infection

scientific article published on 19 March 2019

Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination.

scientific article published on October 1999

β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia

scientific article published on 17 May 2011