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List of works by Jenny Morton

A Significance Test for Inferring Affiliation Networks from Spatio-Temporal Data

scientific article

A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease.

scientific article published in February 2005

A comparison of discrimination learning in touchscreen and 2-choice swim tank using an allelic series of Huntington's disease mice

scientific article published on 25 July 2015

A mobile, high-throughput semi-automated system for testing cognition in large non-primate animal models of Huntington disease

scientific article published on 28 August 2015

A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse

scientific article published on October 2005

A single dose of hypnotic corrects sleep and EEG abnormalities in symptomatic Huntington's disease mice

scientific article published on 21 January 2016

A stop-signal task for sheep: introduction and validation of a direct measure for the stop-signal reaction time.

scientific article published on 7 April 2017

Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light

scientific article published on 01 November 2019

Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation.

scientific article published in July 2000

Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease.

scientific article

Abnormalities of neurogenesis in the R6/2 mouse model of Huntington's disease are attributable to the in vivo microenvironment.

scientific article published on December 2005

Accelerated Differentiation in Response to Retinoic Acid After Retrovirally Mediated Gene Transfer of GAP-43 into Mouse Neuroblastoma Cells

scientific article published on January 1992

Adaptation to experimental jet-lag in R6/2 mice despite circadian dysrhythmia

scientific article

Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice

scientific article published on 3 February 2015

Allelic series of Huntington's disease knock-in mice reveals expression discorrelates

scientific article published on 14 February 2016

An EEG Investigation of Sleep Homeostasis in Healthy and CLN5 Batten Disease Affected Sheep.

scientific article published in August 2016

Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington's disease

scientific article published in Scientific Reports

Artificial miRNAs reduce human mutant Huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease.

scientific article published on 5 December 2017

Asymptomatic sleep abnormalities are a common early feature in patients with Huntington's disease

scientific article published in April 2011

Atrophy and degeneration in sciatic nerve of presymptomatic mice carrying the Huntington's disease mutation

scientific article

Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington's disease

scientific article

Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents.

scientific article published on 21 July 2005

Automated detection and characterisation of rumination in sheep using in vivo electrophysiology

scientific article

Behavioral therapy reverses circadian deficits in a transgenic mouse model of Huntington's disease

scientific article published on 20 November 2013

Beneficial effects of environmental enrichment and food entrainment in the R6/2 mouse model of Huntington's disease

scientific article

Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutation

scientific article published on 18 April 2006

Cerebellar neurons and glia respond differentially to endothelins and sarafotoxin S6b.

scientific article published in May 1992

Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington's disease

scientific article published on May 2017

Characteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans

scientific article published on 11 June 2020

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

scientific article

Characterizing Sleep Spindles in Sheep

scientific article published on 18 March 2020

Choosing an animal model for the study of Huntington's disease

scientific article

Chronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington's Disease Mice

scientific article

Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation

scientific article published in August 2003

Chronic paroxetine treatment prevents disruption of methamphetamine-sensitive circadian oscillator in a transgenic mouse model of Huntington's disease

scientific article

Circadian and sleep disorder in Huntington's disease ⬇️

scientific article published on October 22, 2012

Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo

scientific article

Compartmental loss of NADPH diaphorase in the neuropil of the human striatum in Huntington's disease.

scientific article published on March 1993

Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal

scientific article

Complexin II is essential for normal neurological function in mice

scientific article published on 29 July 2003

Data-loggers carried on a harness do not adversely affect sheep locomotion ⬇️

scientific article published on July 6, 2011

Delayed Onset and Reduced Cognitive Deficits through Pre-Conditioning with 3-Nitropropionic Acid is Dependent on Sex and CAG Repeat Length in the R6/2 Mouse Model of Huntington's Disease

scientific article

Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HD.

scientific article

Differential messenger RNA expression of complexins in mouse brain

scientific article published on March 2004

Differential morphology and composition of inclusions in the R6/2 mouse and PC12 cell models of Huntington's disease.

scientific article

Direct Visualisation of Abnormal Dendritic Spine Morphology in the Hippocampus of the R6/2 Transgenic Mouse Model of Huntington's Disease

scientific article published in January 2012

Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease

scientific article

Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease.

scientific article published in January 2005

Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding

scientific article published in July 2010

Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.

scientific article published in December 1998

Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease

scientific article

Early Neurodegeneration in R6/2 Mice Carrying the Huntington's Disease Mutation with a Super-Expanded CAG Repeat, Despite Normal Lifespan

scientific article published in January 2018

Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment

scientific article published on 31 January 2014

Early motor development is abnormal in complexin 1 knockout mice

scientific article

Erratum to: Chronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington's Disease Mice

scientific article published on 25 July 2017

Erratum to: Large-Brained Animal Models of Huntington's Disease: Sheep

scientific article published on 01 January 2018

Executive decision-making in the domestic sheep

scientific article

Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age.

scientific article

Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II

scientific article (publication date: 15 August 2003)

Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates

scientific article published in January 2013

Hand tapping: a simple, reproducible, objective marker of motor dysfunction in Huntington's disease.

scientific article published on 13 May 2008

Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy

scientific article

Identifying sleep disturbances in Huntington's disease using a simple disease-focused questionnaire

scientific article

Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions

scientific article published on 11 November 2008

Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington's Disease

scientific article published on 16 May 2016

Increased metabolism in the R6/2 mouse model of Huntington's disease.

scientific article

Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?

scientific article published on 06 December 2019

Increased thirst and drinking in Huntington's disease and the R6/2 mouse

scientific article published on 9 January 2008

Indices of comparative cognition: assessing animal models of human brain function

scientific article published on 28 September 2018

Large genetic animal models of Huntington's Disease

scientific article

Large-Brained Animal Models of Huntington's Disease: Sheep

scientific article published on 01 January 2018

Limbic neurogenesis/plasticity in the R6/2 mouse model of Huntington's disease

scientific article published in October 2006

Localization of endothelin-1 (ET-1), ET-2, and ET-3, mouse VIC, and sarafotoxin S6b binding sites in mammalian heart and kidney

scientific article published in January 1991

Longitudinal Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging in Sheep (Ovis aries) With Quinolinic Acid Lesions of the Striatum: Time-Dependent Recovery of N-Acetylaspartate and Fractional Anisotropy

scientific article published on 02 August 2020

Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease

scientific article published on 18 May 2009

Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system

Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers

scientific article published on 22 February 2017

Methamphetamine toxicity in mice is potentiated by exposure to loud music.

scientific article

Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity.

scientific article published in November 2000

Microglia density decreases with age in a mouse model of Huntington's disease.

scientific article published in September 2003

Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients

scientific article

Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice.

scientific article published on 11 December 2008

Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease

scientific article published on 13 February 2011

Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease.

scientific article

Potential molecular consequences of transgene integration: The R6/2 mouse example

scientific article published on 25 January 2017

Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits

scientific article published on 6 July 2005

Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington's disease

scientific article

Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation

scientific article published in December 2004

Progressive gene dose-dependent disruption of the methamphetamine-sensitive circadian oscillator-driven rhythms in a knock-in mouse model of Huntington's disease

scientific article published on 16 September 2016

Progressive imbalance in the interaction between spatial and procedural memory systems in the R6/2 mouse model of Huntington's disease

scientific article published on 12 June 2009

Progressive sleep and electroencephalogram changes in mice carrying the Huntington’s disease mutation ⬇️

scientific article published on July 1, 2013

Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington's disease.

scientific article published on 30 November 2016

RAGE is expressed in pyramidal cells of the hippocampus following moderate hypoxic-ischemic brain injury in rats.

scientific article published in March 2003

Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging

scientific article published on 10 July 2015

Regional and progressive changes in brain expression of complexin II in a mouse transgenic for the Huntington's disease mutation

scientific article published in March 2004

Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease

scientific article (publication date: 2010)

Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats

scientific article published on 23 March 2013

Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine

scientific article published on January 2014

Rigidity in social and emotional memory in the R6/2 mouse model of Huntington's disease

scientific article

Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation.

scientific article published in December 1999

Selfish-herd behaviour of sheep under threat ⬇️

scientific article published on July 24, 2012

Sheep recognize familiar and unfamiliar human faces from two-dimensional images

scientific article published on 8 November 2017

Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy

scientific article published on 20 September 2016

Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease

scientific article published in March 2018

Social Behaviour is Impaired in the R6/2 Mouse Model of Huntington’s Disease

scientific article published on January 2015

Solving the shepherding problem: heuristics for herding autonomous, interacting agents ⬇️

scientific article

Syncollin is required for efficient zymogen granule exocytosis

scientific article published on February 2005

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

scientific article

Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice.

scientific article

Techniques for chronic monitoring of brain activity in freely moving sheep using wireless EEG recording

scientific article published on 30 November 2016

Temporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutation

scientific article (publication date: 2012)

Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse

scientific article

The Cambridge MRI database for animal models of Huntington disease

scientific article published on May 2015

The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function

scientific article published on 14 November 2008

The metabolic profile of early Huntington's disease--a combined human and transgenic mouse study

scientific article published on 19 January 2008

The methamphetamine-sensitive circadian oscillator is dysfunctional in a transgenic mouse model of Huntington's disease

scientific article

The morphology of human neuroblastoma cell grafts in the kainic acid-lesioned basal ganglia of the rat.

scientific article published on August 1995

The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington's disease

scientific article

The touchscreen cognitive testing method for rodents: how to get the best out of your rat.

scientific article published on 8 July 2008

Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep.

scientific article

Understanding the concept of a reflective surface: can sheep improve navigational ability through the use of a mirror?

scientific article published on 17 October 2014

Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats

scientific article (publication date: 11 February 2011)

Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease.

scientific article published in October 2008

Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry.

scientific article published in October 2008

Voxel-based morphometry with templates and validation in a mouse model of Huntington’s disease ⬇️

scientific article published on July 6, 2013

Wake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6/2 Mouse Model of Huntington's Disease

scientific article published on 15 April 2020

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent

scientific article published on 9 April 2018

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease

scholarly article by Anne Ast published in September 2018

“Brain training” improves cognitive performance and survival in a transgenic mouse model of Huntington's disease ⬇️

scientific article published on February 13, 2011

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