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List of works by Pádraig D'arcy

A drug screening assay on cancer cells chronically adapted to acidosis

scientific article published on 25 September 2018

A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells.

scientific article published on 21 May 2013

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

scientific article

Activated monocytes augment TRAIL-mediated cytotoxicity by human NK cells through release of IFN-γ

scientific article published on 26 October 2012

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15

scientific article published on 22 October 2019

Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

scientific article published on 08 July 2019

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics.

scientific article published on 11 November 2016

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

scientific article

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

scientific article published on 20 November 2012

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570 ⬇️

scientific article published on 04 July 2020

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

scientific article

Iron chelators target both proliferating and quiescent cancer cells.

scientific article published on 07 December 2016

MYC is downregulated by a mitochondrial checkpoint mechanism.

scientific article published on 6 October 2017

Multipotent mesenchymal stromal cells express FoxP3: a marker for the immunosuppressive capacity?

scientific article

Oncogenic functions of the cancer-testis antigen SSX on the proliferation, survival, and signaling pathways of cancer cells

scientific article

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

scientific article published on 10 June 2019

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

scientific article

Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation

scientific article published on 13 February 2019

Reactivation of p53 function in synovial sarcoma cells by inhibition of p53-HDM2 interaction.

scientific article

Regulation of TRAIL-receptor expression by the ubiquitin-proteasome system.

scientific article

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

scientific article published on 01 April 2019

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth

scientific article

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

scientific article published in 2021

Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling

scientific article published on November 2008

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

scientific article published on 13 November 2015

The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

scientific article published on 8 April 2014

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

scientific article published on 25 August 2018

The oncoprotein SS18-SSX1 promotes p53 ubiquitination and degradation by enhancing HDM2 stability.

scientific article published on January 2008

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

scientific article published on 7 December 2011

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

scientific article published on 06 June 2016

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