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List of works by Alison O'Brien

A novel murine infection model for Shiga toxin-producing Escherichia coli

scientific article

A plant-based oral vaccine to protect against systemic intoxication by Shiga toxin type 2.

scientific article

A single amino acid substitution in the enzymatic domain of cytotoxic necrotizing factor type 1 of Escherichia coli alters the tissue culture phenotype to that of the dermonecrotic toxin of Bordetella spp.

scientific article published on May 2006

Activation of Shiga toxin type 2d (Stx2d) by elastase involves cleavage of the C-terminal two amino acids of the A2 peptide in the context of the appropriate B pentamer

article

Adherence and colonization mechanisms of enteropathogenic and enterohemorrhagic Escherichia coli.

scientific article

Antibodies against hemolysin and cytotoxic necrotizing factor type 1 (CNF1) reduce bladder inflammation in a mouse model of urinary tract infection with toxigenic uropathogenic Escherichia coli

scientific article

Antibodies to intimin and Escherichia coli secreted proteins A and B in patients with enterohemorrhagic Escherichia coli infections

scientific article

Antibody against the carboxyl terminus of intimin alpha reduces enteropathogenic Escherichia coli adherence to tissue culture cells and subsequent induction of actin polymerization.

scientific article

Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli

scientific article

Bacillus anthracis exosporium protein BclA affects spore germination, interaction with extracellular matrix proteins, and hydrophobicity

scientific article

Bacillus cereus G9241 makes anthrax toxin and capsule like highly virulent B. anthracis Ames but behaves like attenuated toxigenic nonencapsulated B. anthracis Sterne in rabbits and mice.

scientific article

Cell surface-localized nucleolin is a eukaryotic receptor for the adhesin intimin-gamma of enterohemorrhagic Escherichia coli O157:H7.

scientific article

Cloning of Shiga-like toxin structural genes from a toxin converting phage of Escherichia coli.

scientific article

Comparative Pathogenicity of Escherichia coli O157 and Intimin-Negative Non-O157 Shiga Toxin-Producing E. coli Strains in Neonatal Pigs ⬇️

scientific article published on November 1, 2003

Comparisons of native Shiga toxins (Stxs) type 1 and 2 with chimeric toxins indicate that the source of the binding subunit dictates degree of toxicity

scientific article

Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci.

scientific article published on October 1980

Cytotoxic necrotizing factor type 1 delivered by outer membrane vesicles of uropathogenic Escherichia coli attenuates polymorphonuclear leukocyte antimicrobial activity and chemotaxis

scientific article

Cytotoxic necrotizing factor type 1 production by uropathogenic Escherichia coli modulates polymorphonuclear leukocyte function.

scientific article

Defect in macrophage effector function confers Salmonella typhimurium susceptibility on C3H/HeJ mice

scientific article published in March 1982

Dementia caregiver intervention research: in search of clinical significance

scientific article

Detection of epithelial-cell injury, and quantification of infection, in the HCT-8 organoid model of cryptosporidiosis

scientific article

Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2☆

article

Dietary choice affects Shiga toxin-producing Escherichia coli (STEC) O157:H7 colonization and disease

scientific article published on 20 May 2013

ENVIRONMENTAL AND HUMAN ISOLATES OF VIBRIO CHOLERAE AND VIBRIO PARAHAEMOLYTICUS PRODUCE A SHIGELLA DYSENTERIAE 1 (SHIGA)-LIKE CYTOTOXIN

scientific article published in The Lancet

Escherichia coli O157:H7 infection in Dutch belted and New Zealand white rabbits.

scientific article

Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells

scientific article

Ferrets as a model system for renal disease secondary to intestinal infection with Escherichia coli O157:H7 and other Shiga toxin-producing E. coli

scientific article

Genetic toxoids of Shiga toxin types 1 and 2 protect mice against homologous but not heterologous toxin challenge.

scientific article

Hemolysin of uropathogenic Escherichia coli evokes extensive shedding of the uroepithelium and hemorrhage in bladder tissue within the first 24 hours after intraurethral inoculation of mice.

scientific article published on 28 April 2008

Host Cell Cytotoxicity and Cytoskeleton Disruption by CerADPr, an ADP-Ribosyltransferase of Bacillus cereus G9241 ⬇️

scientific article published on March 20, 2013

Human intestinal tissue and cultured colonic cells contain globotriaosylceramide synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide.

scientific article

Identification and characterization of Shiga toxin type 2 variants in Escherichia coli isolates from animals, food, and humans

scientific article published on 25 July 2008

Immunization of mice with formalin-inactivated spores from avirulent Bacillus cereus strains provides significant protection from challenge with Bacillus anthracis Ames

scientific article

Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor.

scientific article published on June 2004

Macrophage defect and inflammatory cell recruitment dysfunction in Salmonella susceptible C3H/HeJ mice

scientific article published in October 1986

Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice

scientific article

Monoclonal antibody 11E10, which neutralizes shiga toxin type 2 (Stx2), recognizes three regions on the Stx2 A subunit, blocks the enzymatic action of the toxin in vitro, and alters the overall cellular distribution of the toxin.

scientific article published on 11 May 2009

Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody

scientific article

Mouse models of Escherichia coli O157:H7 infection and shiga toxin injection

scientific article

Multicenter evaluation of a sequence-based protocol for subtyping Shiga toxins and standardizing Stx nomenclature

scientific article

Mutations in hns reduce the adherence of Shiga toxin-producing E. coli 091:H21 strain B2F1 to human colonic epithelial cells and increase the production of hemolysin

scientific article

Neutralizing antibodies to Shiga toxin type 2 (Stx2) reduce colonization of mice by Stx2-expressing Escherichia coli O157:H7.

scientific article

New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli

scientific article

Novel three-dimensional organoid model for evaluation of the interaction of uropathogenic Escherichia coli with terminally differentiated human urothelial cells.

scientific article

One of two copies of the gene for the activatable shiga toxin type 2d in Escherichia coli O91:H21 strain B2F1 is associated with an inducible bacteriophage

scientific article

Overview and Historical Perspectives

scientific article

PURIFICATION OF SHIGELLA DYSENTERIAE 1 (SHIGA)-LIKE TOXIN FROM ESCHERICHIA COLI 0157:H7 STRAIN ASSOCIATED WITH HAEMORRHAGIC COLITIS

scientific article published in The Lancet

Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora

scientific article

Pathogenesis of Shiga-toxin producing escherichia coli.

scientific article published on January 2012

Phase 1 safety and pharmacokinetic study of chimeric murine-human monoclonal antibody c alpha Stx2 administered intravenously to healthy adult volunteers.

scientific article

Production of Shiga-Like Toxin by Escherichia coli

article

Production of a Shiga-like cytotoxin by Campylobacter

scientific article published in June 1988

Purification and some properties of a Vero toxin from a human strain of Escherichia coli that is immunologically related to Shiga-like toxin II (VT2)

scientific article published on 01 February 1989

Rapid detection of Shiga toxin-producing Escherichia coli by optical immunoassay.

scientific article published on August 2007

Recombinant exosporium protein BclA of Bacillus anthracis is effective as a booster for mice primed with suboptimal amounts of protective antigen.

scientific article

Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin.

scientific article published on 23 June 2015

Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

scientific article

Shiga Toxin (Stx) Type 1a Reduces the Oral Toxicity of Stx Type 2a

scientific article published on 6 January 2016

Shiga Toxins: Potent Poisons, Pathogenicity Determinants, and Pharmacological Agents.

scientific article

Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization.

scholarly article

Shiga toxin type 2dact displays increased binding to globotriaosylceramide in vitro and increased lethality in mice after activation by elastase

scientific article

Shiga toxin-producing Escherichia coli in Montana: bacterial genotypes and clinical profiles

scientific article

Shiga-like toxin converting phage of enterohemorrhagic Escherichia coli strain 933.

scientific article published in May 1989

Shiga-like toxin production from Escherichia coli associated with calf diarrhoea

article

Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea.

scientific article

Statement on scientific publication and security.

scientific article

Statement on the consideration of biodefence and biosecurity

scientific article published in Nature

Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7.

scientific article published on 9 April 2004

The Salmonella typhimurium flgM gene, which encodes a negative regulator of flagella synthesis and is involved in virulence, is present and functional in other Salmonella species

scientific article published in January 1996

The economic impact of work and family issues: child care satisfaction and financial considerations of employed mothers

scientific article published in October 2009

The pathogenic mechanisms of Shiga toxin and the Shiga-like toxins ⬇️

scientific article published on August 1, 1991

Two domains of cytotoxic necrotizing factor type 1 bind the cellular receptor, laminin receptor precursor protein.

scientific article

Uncensored exchange of scientific results

scholarly article

Vaccination of pregnant dams with intimin(O157) protects suckling piglets from Escherichia coli O157:H7 infection

scientific article

Virulence Potential of Activatable Shiga Toxin 2d-Producing Escherichia coli Isolates from Fresh Produce.

scientific article published on November 2015

Virulence of the Shiga toxin type 2-expressing Escherichia coli O104:H4 German outbreak isolate in two animal models

scientific article

When a healthy diet turns deadly

scientific article

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