List of works - Michael Ehrmann

A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease

scientific article published on 6 July 2001

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

scientific article published in April 1999

Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ

scientific article published on 03 January 2020

Ahp cyclodepsipeptides: the impact of the Ahp residue on the "canonical inhibition" of S1 serine proteases

scientific article published on 21 June 2013

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

scientific article published in January 2008

Allosteric regulation of proteases

scientific article published on December 2008

Biochemical characterization and mass spectrometric disulfide bond mapping of periplasmic alpha-amylase MalS of Escherichia coli.

scientific article published on August 1997

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

scientific article

Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins

scientific article

Characterization of transmembrane segments 3, 4, and 5 of MalF by mutational analysis

scientific article published on January 2001

Chemical Proteomics versus Leishmaniasis

scholarly article by Michael Ehrmann published in March 2015

Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action

scientific article published on 24 April 2019

Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease

scientific article

Context-dependent effects of charged residues in transmembrane segments of MalF-PhoA fusions

scientific article published in November 2003

Convenient transfer of lacZ-gene fusions to phage M13 by in vivo recombination and their use for nucleotide sequencing

article

Conversion of a regulatory into a degradative protease

scientific article published on 22 February 2010

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

scientific article

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

scientific article

CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis

scientific article

Determinants of Translocation and Folding of TreF, a Trehalase ofEscherichia coli

scientific article published in Journal of Biological Chemistry

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

scientific article

Determinants of regulated proteolysis in signal transduction

scientific article published on January 2007

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

scientific article published on 27 June 2010

Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration

scientific article

Development of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing Cyclodepsipeptides

article

Diversity of allosteric regulation in proteases

scientific article published on 03 December 2012

E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe-Phe bonds.

scientific article

Epigenetic silencing of serine protease HTRA1 drives polyploidy.

scientific article

Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY.

scientific article published on November 2001

From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides

scientific article published on 01 February 2020

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

article

Genetic analysis of 15 protein folding factors and proteases of the Escherichia coli cell envelope

scientific article

HTRA proteases: regulated proteolysis in protein quality control

scientific article published on 16 February 2011

HTRA1-Dependent Cell Cycle Proteomics

scientific article published on 13 July 2018

HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival.

scientific article published on 13 June 2008

Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein.

scientific article published in October 2012

Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry

scientific article published in January 2005

Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes.

scientific article published on 16 April 2018

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

scientific article published on 12 July 2013

Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy

scientific article published on 20 August 2007

Identification of the Natural Product Rotihibin A as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling

scientific article published on 27 July 2018

Implications of the serine protease HtrA1 in amyloid precursor protein processing

scientific article

Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis.

scientific article published in May 2018

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

scholarly article

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

scientific article (publication date: 26 October 2011)

Membrane topology of CadA homologous P-type ATPase of Helicobacter pylori as determined by expression of phoA fusions in Escherichia coli and the positive inside rule

scientific article published in October 1999

Membrane topology of the xenobiotic-exporting subunit, MexB, of the MexA,B-OprM extrusion pump in Pseudomonas aeruginosa.

scientific article

MiR-30e and miR-181d control radial glia cell proliferation via HtrA1 modulation

scientific article

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

scientific article

Molecular transformers in the cell: lessons learned from the DegP protease-chaperone

scientific article

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

scientific article published on 30 July 2018

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

scientific article

Peptide Functionalized Polydiacetylene Liposomes Act as a Fluorescent Turn-On Sensor for Bacterial Lipopolysaccharide

scientific article published in 2011

Peptidic small molecule activators of the stress sensor DegS.

scientific article published on 8 May 2009

Persister state-directed transitioning and vulnerability in melanoma

scientific article published on 01 June 2022

Polypeptide binding of Escherichia coli FtsH (HflB).

scientific article published in May 1998

Protein Folding in the Periplasm and Outer Membrane ofE. coli

Protein quality control in the bacterial periplasm

scientific article published on January 2011

Proteolysis as a regulatory mechanism

scientific article

Rational correction of pathogenic conformational defects in HTRA1

scientific article published in 2024

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

scientific article

Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis

scientific article published on 13 March 2015

SecA-dependent quality control of intracellular protein localization

scientific article

Selectivity profiling of DegP substrates and inhibitors

scientific article published on 5 February 2009

Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

scientific article

Small Molecules from Deep within the Gut.

scientific article published on 27 March 2017

Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A.

scientific article published on 22 October 2010

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

scientific article

Structural basis for the regulated protease and chaperone function of DegP

scientific article

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

scientific article published on 18 August 2009

Substrate occupancy at the onset of oligomeric transitions of DegP.

scientific article published on 26 December 2013

Substrate-induced remodeling of the active site regulates human HTRA1 activity

scientific article

Synthetic competition between cytoplasmic folding and translocation of a soluble membrane protein domain

article

Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors

scientific article published on 17 May 2017

Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions.

scientific article published on 16 February 2017

Target-directed proteolysis at the ribosome

scientific article

Target-directed proteolysis in vivo

scientific article published on January 2007

The HtrA Family of Proteases

scientific article (publication date: September 2002)

The Protein Translocation Apparatus Contributes to Determining the Topology of an Integral Membrane Protein inEscherichia coli

scientific article published in Journal of Biological Chemistry

The Saccharomyces cerevisiae gene PPH3 encodes a protein phosphatase with properties different from PPX, PP1 and PP2A.

scientific article

The role of human HtrA1 in arthritic disease

scientific article

The serine protease HtrA1 is a novel prognostic factor for human mesothelioma

scientific article

The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein

scientific article published on 29 July 2010

TnTIN and TnTAP: mini-transposons for site-specific proteolysis in vivo

scientific article published on November 1997

Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles

scientific article

Utilities for Mass Spectrometry Analysis of Proteins (UMSAP): Fast post-processing of mass spectrometry data

scientific article published on 01 October 2018

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

scientific article

List of works by Michael Ehrmann

A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ

Ahp cyclodepsipeptides: the impact of the Ahp residue on the "canonical inhibition" of S1 serine proteases

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

Allosteric regulation of proteases

Biochemical characterization and mass spectrometric disulfide bond mapping of periplasmic alpha-amylase MalS of Escherichia coli.

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins

Characterization of transmembrane segments 3, 4, and 5 of MalF by mutational analysis

Chemical Proteomics versus Leishmaniasis

Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action

Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease

Context-dependent effects of charged residues in transmembrane segments of MalF-PhoA fusions

Convenient transfer of lacZ-gene fusions to phage M13 by in vivo recombination and their use for nucleotide sequencing

Conversion of a regulatory into a degradative protease

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis

Determinants of Translocation and Folding of TreF, a Trehalase ofEscherichia coli

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

Determinants of regulated proteolysis in signal transduction

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration

Development of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing Cyclodepsipeptides

Diversity of allosteric regulation in proteases

E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe-Phe bonds.

Epigenetic silencing of serine protease HTRA1 drives polyploidy.

Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY.

From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

Genetic analysis of 15 protein folding factors and proteases of the Escherichia coli cell envelope

HTRA proteases: regulated proteolysis in protein quality control

HTRA1-Dependent Cell Cycle Proteomics

HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival.

Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein.

Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry

Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes.

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy

Identification of the Natural Product Rotihibin A as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling

Implications of the serine protease HtrA1 in amyloid precursor protein processing

Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis.

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

Membrane topology of CadA homologous P-type ATPase of Helicobacter pylori as determined by expression of phoA fusions in Escherichia coli and the positive inside rule

Membrane topology of the xenobiotic-exporting subunit, MexB, of the MexA,B-OprM extrusion pump in Pseudomonas aeruginosa.

MiR-30e and miR-181d control radial glia cell proliferation via HtrA1 modulation

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

Molecular transformers in the cell: lessons learned from the DegP protease-chaperone

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

Peptide Functionalized Polydiacetylene Liposomes Act as a Fluorescent Turn-On Sensor for Bacterial Lipopolysaccharide

Peptidic small molecule activators of the stress sensor DegS.

Persister state-directed transitioning and vulnerability in melanoma

Polypeptide binding of Escherichia coli FtsH (HflB).

Protein Folding in the Periplasm and Outer Membrane ofE. coli

Protein quality control in the bacterial periplasm

Proteolysis as a regulatory mechanism

Rational correction of pathogenic conformational defects in HTRA1

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis

SecA-dependent quality control of intracellular protein localization

Selectivity profiling of DegP substrates and inhibitors

Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

Small Molecules from Deep within the Gut.

Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A.

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

Structural basis for the regulated protease and chaperone function of DegP

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

Substrate occupancy at the onset of oligomeric transitions of DegP.

Substrate-induced remodeling of the active site regulates human HTRA1 activity

Synthetic competition between cytoplasmic folding and translocation of a soluble membrane protein domain

Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors

Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions.

Target-directed proteolysis at the ribosome

Target-directed proteolysis in vivo

The HtrA Family of Proteases

The Protein Translocation Apparatus Contributes to Determining the Topology of an Integral Membrane Protein inEscherichia coli