List of works - Vincent Walter Bloks

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

scientific article

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats

scientific journal article

A novel approach to monitor glucose metabolism using stable isotopically labelled glucose in longitudinal studies in mice

scientific article published on 14 March 2013

Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice

scientific article published on 13 April 2006

Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease

scientific article published in January 2010

An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice

scientific article published on 9 February 2009

Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver

scientific article published on 01 December 1999

Beyond intestinal soap--bile acids in metabolic control.

scientific article published on 13 May 2014

Bile acid sequestration normalizes plasma cholesterol and reduces atherosclerosis in hypercholesterolemic mice. No additional effect of physical activity

scientific article published on 26 February 2013

Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria

scientific article published on 01 September 1999

Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice

scientific article published on June 2011

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha

scientific article published on 04 November 2006

Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance

scientific article published on 31 May 2012

Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice

scientific article published on 25 February 2010

Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction.

scientific article published on 5 December 2014

Cross-talk between liver and intestine in control of cholesterol and energy homeostasis

scientific article published on 18 February 2014

Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats.

scientific article

Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice

scientific journal article

Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes

scientific journal article

Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance

scientific article published on 29 May 2018

Essential fatty acid deficiency in mice is associated with hepatic steatosis and secretion of large VLDL particles

scientific article published on 20 January 2005

Gene expression profiling in livers of mice after acute inhibition of beta-oxidation.

scientific article published on 22 October 2007

HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL.

scientific article published on 26 January 2016

Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice

scientific article

Hepatic lipid accumulation, altered very low density lipoprotein formation and apolipoprotein E deposition in apolipoprotein E3-Leiden transgenic mice

scientific article published on 01 August 2000

Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL

scientific article

Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes

scientific article published on 17 April 2016

Hypoxia and Complement-and-Coagulation Pathways in the Deceased Organ Donor as the Major Target for Intervention to Improve Renal Allograft Outcome.

scientific article published on June 2015

Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism

scientific article published on October 2010

In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation

scientific article published on 01 May 2014

Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.

scientific article published on 8 July 2002

Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse

scientific article

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia

scientific article published on 12 April 2017

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

scientific article published on 11 August 2009

Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration

article

Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice

scientific article

Maternal western diet primes non-alcoholic fatty liver disease in adult mouse offspring

scientific article published in January 2014

Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria.

scientific article published in February 2002

Metabolic responses to long-term pharmacological inhibition of CB1-receptor activity in mice in relation to dietary fat composition

scientific article published on 20 October 2009

Milk cholesterol concentration in mice is not affected by high cholesterol diet- or genetically-induced hypercholesterolaemia.

scientific article

Neonatal dexamethasone administration causes progressive renal damage due to induction of an early inflammatory response

scientific article published on 30 January 2008

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

scientific article

Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.

scientific article

Postnatal treatment with dexamethasone perturbs hepatic and cardiac energy metabolism and is associated with a sustained atherogenic plasma lipid profile in suckling rats

scientific article published on 01 February 2007

Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter

scientific article published on 01 August 2006

Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha

scientific journal article

Reply to: "Impaired expression of multidrug resistance-associated protein 2 and liver damage in erythropoietic protoporphyria"

scientific article published on 21 August 2015

Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function.

scientific article published on 27 December 2011

Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-leiden mice

scientific article published in January 2005

Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion

scientific article published on 25 November 2007

Sex-specific placental differences as a contributor to sex-specific metabolic programming?

scientific article published on 26 August 2015

Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.

scientific article

The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction.

scientific article published on 4 November 2009

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

scientific article published on 26 June 2007

The role of transhepatic bile salt flux in the control of hepatic secretion of triacylglycerol-rich lipoproteins in vivo in rodents

scientific article published in October 2002

Two time-point assessment of bile acid kinetics in humans using stable isotopes

scientific article published on September 2010

List of works by Vincent Walter Bloks

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats

A novel approach to monitor glucose metabolism using stable isotopically labelled glucose in longitudinal studies in mice

Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice

Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease

An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice

Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver

Beyond intestinal soap--bile acids in metabolic control.

Bile acid sequestration normalizes plasma cholesterol and reduces atherosclerosis in hypercholesterolemic mice. No additional effect of physical activity

Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria

Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha

Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance

Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice

Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction.

Cross-talk between liver and intestine in control of cholesterol and energy homeostasis

Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats.

Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice

Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes

Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance

Essential fatty acid deficiency in mice is associated with hepatic steatosis and secretion of large VLDL particles

Gene expression profiling in livers of mice after acute inhibition of beta-oxidation.

HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL.

Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice

Hepatic lipid accumulation, altered very low density lipoprotein formation and apolipoprotein E deposition in apolipoprotein E3-Leiden transgenic mice

Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL

Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes

Hypoxia and Complement-and-Coagulation Pathways in the Deceased Organ Donor as the Major Target for Intervention to Improve Renal Allograft Outcome.

Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism

In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation

Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.

Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration

Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice

Maternal western diet primes non-alcoholic fatty liver disease in adult mouse offspring

Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria.

Metabolic responses to long-term pharmacological inhibition of CB1-receptor activity in mice in relation to dietary fat composition

Milk cholesterol concentration in mice is not affected by high cholesterol diet- or genetically-induced hypercholesterolaemia.

Neonatal dexamethasone administration causes progressive renal damage due to induction of an early inflammatory response

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.

Postnatal treatment with dexamethasone perturbs hepatic and cardiac energy metabolism and is associated with a sustained atherogenic plasma lipid profile in suckling rats

Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter

Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha

Reply to: "Impaired expression of multidrug resistance-associated protein 2 and liver damage in erythropoietic protoporphyria"

Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function.

Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-leiden mice

Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion

Sex-specific placental differences as a contributor to sex-specific metabolic programming?

Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.

The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction.

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

The role of transhepatic bile salt flux in the control of hepatic secretion of triacylglycerol-rich lipoproteins in vivo in rodents

Two time-point assessment of bile acid kinetics in humans using stable isotopes