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List of works by Yang Yang

Acute exposure of methylglyoxal leads to activation of KATP channels expressed in HEK293 cells.

scientific article published on 14 October 2013

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain.

scientific article

Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer.

scientific article published on 22 August 2007

Familial gain-of-function Nav1.9 mutation in a painful channelopathy.

scientific article published on 8 August 2016

Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47.

scientific article published on 3 October 2006

Impairment of the Vascular KATP Channel Imposes Fatal Susceptibility to Experimental Diabetes Due to Multi-Organ Injuries.

scientific article

Inhibition of AF116909 gene expression enhances the differentiation of neural stem cells

scientific article published in July 2005

K(ATP) channel action in vascular tone regulation: from genetics to diseases.

scientific article

Molecular basis and structural insight of vascular K(ATP) channel gating by S-glutathionylation.

scientific article

Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state.

scientific article

NaV1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine.

scientific article published on 19 January 2018

Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli.

scientific article published on July 2016

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

scientific article published on 15 June 2012

Network topology of NaV1.7 mutations in sodium channel-related painful disorders.

scientific article

Oxidative Stress Inhibits Vascular KATP Channels by S-Glutathionylation ⬇️

scientific article published on October 6, 2010

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.

scientific article published on 18 April 2016

Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability

scientific article

Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp

scientific article published on 20 November 2018

Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T.

scientific article published on 28 June 2017

Rosiglitazone inhibits vascular KATP channels and coronary vasodilation produced by isoprenaline.

scientific article published on December 2011

S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress

scientific article published on 20 August 2012

S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk, and mechanosensing

scientific article published on 20 August 2013

Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons.

scientific article published in August 2013

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

scientific article published on January 2012

The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy.

scientific article published on 20 March 2015

The Na(V)1.7 sodium channel: from molecule to man.

scientific article published on 12 December 2012

bFGF and heparin but not laminin are necessary factors in the mediums that affect NSCs differentiation into cholinergic neurons

scientific article published in January 2006

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