List of works - Jesper Nylandsted

A Method to Monitor Lysosomal Membrane Permeabilization by Immunocytochemistry.

scientific article published on October 2015

A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions.

scientific article

Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair.

scientific article

Annexin A4 trimers are recruited by high membrane curvatures in giant plasma membrane vesicles

scientific article published on 05 August 2020

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

scientific article published on 30 April 2019

Annexins Bend Wound Edges during Plasma Membrane Repair

scientific article published on 21 January 2019

Annexins are instrumental for efficient plasma membrane repair in cancer cells.

scientific article

Annexins in plasma membrane repair

scientific article published on 24 June 2016

Annexins induce curvature on free-edge membranes displaying distinct morphologies.

scientific article published on 9 July 2018

Annexins: players of single cell wound healing and regeneration

scientific article published on 13 October 2019

Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

scientific article published in 2024

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

scientific article

Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.

scientific article

BAMLET activates a lysosomal cell death program in cancer cells.

scientific article

CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

scientific article published on 17 July 2021

Calcium electroporation and electrochemotherapy for cancer treatment: Importance of cell membrane composition investigated by lipidomics, calorimetry and in vitro efficacy

article

Curvature- and Phase-Induced Protein Sorting Quantified in Transfected Cell-Derived Giant Vesicles

scientific article published on 14 June 2019

Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells

scientific article (publication date: 2009)

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

scientific article published on 16 September 2016

ErbB2-associated changes in the lysosomal proteome.

scientific article published on 14 June 2011

ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.

scientific article

Expression of a p16INK4a-specific ribozyme downmodulates p16INK4a abundance and accelerates cell proliferation

scientific article published on 01 September 1998

Extracellular heat shock protein 70: a potential prognostic marker for chronic myeloid leukemia

scientific article published on 26 August 2008

Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins.

scientific article published on 31 August 2004

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

scientific article published on August 2004

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.

scientific article

Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells

scientific article

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

scientific article

Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.

scientific article published on 25 October 2003

Liprotides kill cancer cells by disrupting the plasma membrane

scientific article published on 9 November 2017

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

scientific article published on March 2005

Methods for Probing Lysosomal Membrane Permeabilization.

scientific article published on 2 November 2015

Methods for the quantification of lysosomal membrane permeabilization: a hallmark of lysosomal cell death

scientific article published on 14 January 2015

NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance.

scientific article published on 11 June 2010

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

scientific article

Phenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair

scientific article published on 26 July 2021

Quantification of Lysosomal Membrane Permeabilization by Cytosolic Cathepsin and β-N-Acetyl-Glucosaminidase Activity Measurements

scientific article published on 2 November 2015

Quantitative Profiling of Lysosomal Lipidome by Shotgun Lipidomics

scientific article

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

scientific article

S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells

scientific article

S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

scientific article

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

scientific article

Short-term transcriptomic response to plasma membrane injury

scientific article published on 27 September 2021

Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance

scientific article

Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase

scientific article published on September 2013

Using Liprotides to Deliver Cholesterol to the Plasma Membrane

scientific article published on 17 April 2018

Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine.

scientific article

Visualizing Lysosomal Membrane Permeabilization by Fluorescent Dextran Release.

scientific article published on October 2015

List of works by Jesper Nylandsted

A Method to Monitor Lysosomal Membrane Permeabilization by Immunocytochemistry.

A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions.

Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair.

Annexin A4 trimers are recruited by high membrane curvatures in giant plasma membrane vesicles

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Annexins Bend Wound Edges during Plasma Membrane Repair

Annexins are instrumental for efficient plasma membrane repair in cancer cells.

Annexins in plasma membrane repair

Annexins induce curvature on free-edge membranes displaying distinct morphologies.

Annexins: players of single cell wound healing and regeneration

Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.

BAMLET activates a lysosomal cell death program in cancer cells.

CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

Calcium electroporation and electrochemotherapy for cancer treatment: Importance of cell membrane composition investigated by lipidomics, calorimetry and in vitro efficacy

Curvature- and Phase-Induced Protein Sorting Quantified in Transfected Cell-Derived Giant Vesicles

Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

ErbB2-associated changes in the lysosomal proteome.

ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.

Expression of a p16INK4a-specific ribozyme downmodulates p16INK4a abundance and accelerates cell proliferation

Extracellular heat shock protein 70: a potential prognostic marker for chronic myeloid leukemia

Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins.

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.

Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.

Liprotides kill cancer cells by disrupting the plasma membrane

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

Methods for Probing Lysosomal Membrane Permeabilization.

Methods for the quantification of lysosomal membrane permeabilization: a hallmark of lysosomal cell death

NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance.

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

Phenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair

Quantification of Lysosomal Membrane Permeabilization by Cytosolic Cathepsin and β-N-Acetyl-Glucosaminidase Activity Measurements

Quantitative Profiling of Lysosomal Lipidome by Shotgun Lipidomics

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells

S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

Short-term transcriptomic response to plasma membrane injury

Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance

Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase

Using Liprotides to Deliver Cholesterol to the Plasma Membrane

Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine.

Visualizing Lysosomal Membrane Permeabilization by Fluorescent Dextran Release.