Search filters

List of works by Percy A. Knolle

"To Be or Not to Be": Immune Tolerance in Chronic Hepatitis B.

scientific article published in October 2016

A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection

scientific article

A human schwannoma cell line supports the in vitro adhesion of Plasmodium falciparum infected erythrocytes to chondroitin-4-sulfate.

scientific article published on 8 October 2002

A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells

scientific article

A soluble form of the adhesion receptor CD58 (LFA‐3) is present in human body fluids ⬇️

scientific article published on November 1, 1993

Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion

scientific article

Acute respiratory failure in tropical malaria during pregnancy. Successful treatment using extracorporeal CO2 elimination

scientific article

Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling

scientific article published on 9 February 2009

Adoptive T-cell therapy to treat liver cancer: is the liver microenvironment key?

scientific article published on August 2013

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention

scientific article published on 01 September 2019

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances.

scientific article published on 26 August 2016

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.

scientific article published on 28 February 2010

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.

scientific article published on 2 June 2016

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis

scientific article published on 6 May 2014

Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity

scientific article

Antigen-presenting cell function in the tolerogenic liver environment.

scientific article

Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells

scientific article published on 01 April 1996

Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms.

scientific article published on 29 January 2013

Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation.

scientific article

B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway

scientific article published on 16 September 2015

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis

scientific article published in June 2008

Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens.

scientific article

Bioluminescence imaging allows measuring CD8 T cell function in the liver

scientific article published in April 2010

Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro.

scientific article published on 24 August 2007

Brucellosis: differential diagnosis of acute abdominal pain.

scientific article published on November 1993

CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.

scientific article published on 21 February 2012

Checkpoint Inhibition in Head and Neck Cancer: Immune Therapeutic Options, Limitations, and Beyond.

scientific article published on 24 February 2017

Circulating ICAM-1 (sCD54) and LFA-3 (sCD58) in chronic hepatitis B--a longitudinal study in patients treated with interferon-alpha

scientific article published in June 1997

Comparative approach to define increased regulatory T cells in different cancer subtypes by combined assessment of CD127 and FOXP3.

scientific article

Complete congenital heart block in autoimmune hepatitis (SLA-positive)

scientific article published on 01 August 1994

Control of immune responses by savenger liver endothelial cells.

scientific article published on September 2003

CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes

scientific article published in December 2002

Cross-presentation of antigens from apoptotic tumor cells by liver sinusoidal endothelial cells leads to tumor-specific CD8+ T cell tolerance

scientific article published on 01 November 2006

Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance

scientific article published on 01 October 2005

Cross-priming in health and disease.

scientific article published on June 2010

Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium

scientific article

Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.

scientific article published on 19 January 2016

Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver

article

Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis.

scientific article published on 4 March 2015

Direct activation of human endothelial cells by Plasmodium falciparum-infected erythrocytes

scientific article published on June 2005

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells.

scientific article published in September 2009

Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.

scientific article

Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells

scientific article published on 08 March 2010

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

scientific article published in December 2000

Elevated serum E-selectin in patients with liver metastases of colorectal cancer

scientific article published on 01 June 1996

Endothelial cell-mediated uptake of a hepatitis B virus: a new concept of liver targeting of hepatotropic microorganisms

scientific article published in October 2001

Endotoxin down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells

scientific article published on 01 February 1999

Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting.

scientific article

Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes

scientific article published on 4 May 2005

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis.

scientific article published on 28 October 2011

Fms-like tyrosine kinase 3 receptor ligand (Flt3L)-based vaccination administered with an adenoviral vector prevents tumor growth of colorectal cancer in a BALB/c mouse model

scientific article published on 10 October 2013

Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration.

scientific article published on 30 June 2010

Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice

scientific article published on 8 August 2012

Functional classification of memory CD8(+) T cells by CX3CR1 expression

scientific article

Global transcriptional characterization of CD8+ T cell memory

scientific article published on February 2015

Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.

scientific article published on 18 July 2016

HIV and pregnancy: risks of transmission and therapeutic possibilities

scientific article published in January 1996

Hepatic immune regulation and its involvement in viral hepatitis infection.

scientific article published on 08 January 2014

Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium.

scientific article published on 31 January 2009

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.

scientific article

Hitting the right button: MAVS-mediated defense against HAV infection.

scientific article

Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge

article

IAP antagonization promotes inflammatory destruction of vascular endothelium

scientific article published on 30 March 2015

IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules

scientific article published on 01 December 1998

IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function

scientific article published on 4 September 2014

Immediate antigen-specific effector functions by TCR-transgenic CD8+ NKT cells

scientific article published on 01 March 2006

Immunological functions of liver sinusoidal endothelial cells

scientific article

Immunomodulatory effects of the liver: deletion of activated CD4+ effector cells and suppression of IFN-gamma-producing cells after intravenous protein immunization

scientific article published on 01 September 2002

In vivo expansion of naïve CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration

scientific article (publication date: 2012)

In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma

scientific article published on 12 January 2006

Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models

scientific article

Inactivated Orf virus (Parapoxvirus ovis) elicits antifibrotic activity in models of liver fibrosis.

scientific article published on 13 September 2012

Inactivated orf virus (Parapoxvirus ovis) induces antitumoral activity in transplantable tumor models.

scientific article

Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus

scientific article published in July 2003

Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failure.

scientific article published on August 2006

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 04 November 2020

Interfering with Kupffer cell replenishment: New insights into liver injury.

scientific article published on 17 February 2018

Interleukin-10 expression is autoregulated at the transcriptional level in human and murine kupffer cells

scientific article published on 01 January 1998

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection

scientific article published on 14 April 2013

Involvement of the liver in the induction of CD8 T cell tolerance towards oral antigen.

scientific article

Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria.

scientific article

Kidney dendritic cells induce innate immunity against bacterial pyelonephritis

scientific article

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

scientific article

Lack of PPARγ in myeloid cells confers resistance to Listeria monocytogenes infection

scientific article

Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ.

scientific article published on 24 March 2012

Ligase chain reaction (LCR) assay for semi-quantitative detection of HBV DNA in mononuclear leukocytes of patients with chronic hepatitis B

scientific article published on 01 September 1996

Liver Sinusoidal Endothelial Cells Are Not Permissive for Adenovirus Type 5

scientific article published on 01 February 2000

Liver X receptor activation promotes differentiation of regulatory T cells

scientific article published on 19 September 2017

Liver macrophages in healthy and diseased liver

scientific article published on 14 March 2017

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

scientific article published on 23 December 2016

Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time

scientific article

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice

scientific article published on 14 October 2012

Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells

scientific article published on 01 April 2008

Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity

scientific article published on 14 March 2013

Living in the liver: hepatic infections ⬇️

scientific article published on February 24, 2012

MHC class II genes influence the susceptibility to chronic active hepatitis C ⬇️

scientific article published on August 1, 1997

Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.

scientific article published on 06 September 2016

Mechanisms balancing tolerance and immunity in the liver

scientific article published on 30 August 2011

Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes

scientific article

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis ⬇️

scientific article published on October 1, 2010

Molecular fingerprinting and autocrine growth regulation of endothelial cells in a murine model of hepatocellular carcinoma.

scientific article

Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1.

scientific article published on 24 January 2008

Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism.

scientific article published on July 2011

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

scientific article published on 29 October 2018

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

scientific article published on 24 March 2021

NF-kappa B antisense oligonucleotides reduce leukocyte-endothelial interaction in hepatic ischemia-reperfusion

scientific article published on 01 November 2001

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

scientific article published on 5 June 2015

Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells.

scientific article

Normal interleukin-12 production in individuals with antibodies to Helicobacter pylori

scientific article published on 01 November 1997

Nuclear receptors: TH17 cell control from within.

scientific article published on 07 July 2011

Osteoimmunological mechanisms involved in orthodontically and bacterially induced periodontal stress

scientific article published in December 2012

Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes

scientific article published on 27 September 2018

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

scientific article published in Nature Communications

Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy

scientific article published on 01 February 2007

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

scientific article published on 01 April 2019

Primary tumor-associated expression of CXCR4 predicts formation of local and systemic recurrency in head and neck squamous cell carcinoma.

scientific article published on 20 November 2017

Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients

scientific article

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.

scientific article published in October 2017

Prominent regulatory but weak antigen-presenting cell function of hepatic stellate cells

scientific article published on 01 September 2011

Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 22 December 2020

Quantification and genotyping of serum HCV-RNA in patients with chronic hepatitis C undergoing interferon treatment ⬇️

scientific article published on January 1, 1997

Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction

scientific article published on 21 January 2017

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

scientific article published on 12 October 2012

Rapid and preferential distribution of blood-borne alphaCD3epsilonAb to the liver is followed by local stimulation of T cells and natural killer T cells

Rare pre-core stop-codon mutant nt. 1897 predominates over wide-spread mutant nt. 1896 in an unusual course of chronic hepatitis B.

scientific article

Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine

scientific article published on 24 May 2005

Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10

article

Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo ⬇️

scientific article published on June 11, 2012

Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal

scientific article published on 23 April 2020

Regulatory role of periodontal ligament fibroblasts for innate immune cell function and differentiation

scientific article published on 21 March 2012

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

scientific article published on 14 August 2011

Rescue of T-cell function during persistent pulmonary adenoviral infection by TLR9 activation.

scientific article

STAT5 is an ambivalent regulator of neutrophil homeostasis

scientific article

Scaling of immune responses against intracellular bacterial infection

scientific article published on 15 September 2014

Semiquantitative assessment of pre-core stop-codon mutant and wildtype hepatitis B virus during the course of chronic hepatitis B using a new PCR-based assay

scientific article published in January 1996

Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells

scientific article

Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection. ⬇️

scientific article published on 11 June 2019

Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment

scientific article published on 01 February 2019

Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates

scientific article

Staying local-antigen presentation in the liver

scientific article published on 11 March 2016

Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments

scientific article published on 22 March 2010

Sustained elimination of hepatitis B virus from serum induced in a patient with chronic hepatitis B and advanced human immunodeficiency virus infection

scientific article

Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection

scientific article published on 25 July 2019

Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow.

scientific article published on 03 August 2016

Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization

scientific article published in May 2009

Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.

scientific article published in January 2006

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.

scientific article published on 30 April 2013

T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract.

scientific article published on 28 November 2010

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation.

scientific article published on 3 May 2017

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice.

scientific article published on 22 May 2015

TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation

article by Dirk Wohlleber et al published September 2012 in Cell Reports

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

scientific article published on 17 June 2019

Taking off the brakes: T cell immunity in the liver.

scientific article published on 09 July 2010

Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.

scientific article published on 07 March 2017

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination

scientific article published on 16 June 2017

The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes

scientific article published on 12 August 2013

The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production

scientific article published in Scientific Reports

The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes

scientific article published on 2 February 2012

The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib.

scientific article published on 19 January 2016

The liver's imprint on CD8⁺ T cell priming

scientific article published on 16 July 2012

The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity

scientific article published on 08 September 2009

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

article published in 2009

The role of hepatic immune regulation in systemic immunity to viral infection

scientific article

Therapeutic immunomodulation using a virus--the potential of inactivated orf virus.

scientific article

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice

scientific article published on 24 November 2014

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12

scientific article published on 01 April 1996

Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance

article

Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors

scientific article published in January 2012

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

scientific article published on 26 September 2014

Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.

scientific article

Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation

scientific article published on 13 July 2016

Transfer of HBV Genomes Using Low Doses of Adenovirus Vectors Leads to Persistent Infection in Immune Competent Mice

scientific article published on 14 March 2012

Transfer of T cell surface molecules to dendritic cells upon CD4+ T cell priming involves two distinct mechanisms

scientific article published on 01 September 2008

Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia

scientific article

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection

scientific article

Viral and host factors in the prediction of response to interferon-alpha therapy in chronic hepatitis C after long-term follow-up

scientific article published on November 1998

Virally Infected Mouse Liver Endothelial Cells Trigger CD8+ T-Cell Immunity

[Histopathological research laboratories in translational research : Conception and integration into the infrastructure of pathological institutes]

scientific article published on 01 March 2019

[The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)]

scientific article published on 01 November 2005

Paulina is supported by:

About Paulina

Help