List of works - Concepcion Gonzalez-bello

2-substituted-3-dehydroquinic acids as potent competitive inhibitors of type II dehydroquinase

scientific article published in December 2009

6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens

scientific article published on 31 March 2020

A New Pathway for Protein Haptenation by β-Lactams.

scientific article published on 9 August 2017

A combined photophysical and computational study on the binding of mycophenolate mofetil and its major metabolite to transport proteins

scientific article published on 27 March 2018

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors

scientific article

Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii

scientific article published on 14 August 2017

Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics

scientific article published on 14 August 2017

Challenging Antimicrobial Susceptibility and Evolution of Resistance (OXA-681) during Treatment of a Long-Term Nosocomial Infection Caused by a Pseudomonas aeruginosa ST175 Clone

scientific article published on 23 September 2019

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

scientific article

Comparative binding energy COMBINE analysis for understanding the binding determinants of type II dehydroquinase inhibitors.

scientific article published on March 2013

Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies.

scientific article

Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase.

scientific article published in June 2003

Designing Irreversible Inhibitors--Worth the Effort?

scientific article published on 23 November 2015

Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy

scientific article published on 01 September 2006

Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors

scientific article

Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme.

scientific article published on 4 October 2016

Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies.

scientific article published on 25 August 2015

Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods

scientific article published on 12 October 2019

LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.

scientific article published on 28 April 2016

Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamics simulation studies

scientific article

Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids

scientific article

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases

scientific article published on 01 March 2014

Mechanistic studies on type I and type II dehydroquinase with (6 R )- and (6 S )-6-fluoro-3-dehydroquinic acids

scientific article published on 01 February 2000

Metal-Assisted Ring-Closing/Opening Process of a Chiral Tetrahydroquinazoline

scientific article published on 23 January 2012

Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas aeruginosa infections

scientific article published on 21 October 2020

Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover

scientific article

Nanomolar Competitive Inhibitors ofMycobacterium tuberculosis andStreptomyces coelicolor Type II Dehydroquinase

scientific article published on 01 February 2007

Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase

scientific article

Photobinding of Triflusal to Human Serum Albumin Investigated by Fluorescence, Proteomic Analysis, and Computational Studies

scientific article published on 20 September 2019

QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes

scientific article published on 01 June 2018

Recently developed synthetic compounds with anti-infective activity

scientific article published on 18 April 2019

Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.

scientific article published on 9 August 2017

Specific chemical modification of bacterial type I dehydroquinase--opportunities for drug discovery

scientific article

Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy.

scientific article

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues

scientific article

Synthesis of Polyhydroxycyclohexanes and Relatives from (−)-Quinic Acid†

scientific article published on 01 March 2003

Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme.

scientific article

Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase

scientific article

Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii

scientific article published on 23 September 2019

Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids

scientific article

Using surface enhanced Raman scattering to analyze the interactions of protein receptors with bacterial quorum sensing modulators.

scientific article published on 4 May 2015

β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs

scientific article published on 13 November 2019

List of works by Concepcion Gonzalez-bello

2-substituted-3-dehydroquinic acids as potent competitive inhibitors of type II dehydroquinase

6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens

A New Pathway for Protein Haptenation by β-Lactams.

A combined photophysical and computational study on the binding of mycophenolate mofetil and its major metabolite to transport proteins

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors

Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii

Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics

Challenging Antimicrobial Susceptibility and Evolution of Resistance (OXA-681) during Treatment of a Long-Term Nosocomial Infection Caused by a Pseudomonas aeruginosa ST175 Clone

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

Comparative binding energy COMBINE analysis for understanding the binding determinants of type II dehydroquinase inhibitors.

Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies.

Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase.

Designing Irreversible Inhibitors--Worth the Effort?

Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy

Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors

Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme.

Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies.

Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods

LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.

Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamics simulation studies

Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases

Mechanistic studies on type I and type II dehydroquinase with (6 R )- and (6 S )-6-fluoro-3-dehydroquinic acids

Metal-Assisted Ring-Closing/Opening Process of a Chiral Tetrahydroquinazoline

Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas aeruginosa infections

Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover

Nanomolar Competitive Inhibitors ofMycobacterium tuberculosis andStreptomyces coelicolor Type II Dehydroquinase

Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase

Photobinding of Triflusal to Human Serum Albumin Investigated by Fluorescence, Proteomic Analysis, and Computational Studies

QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes

Recently developed synthetic compounds with anti-infective activity

Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.

Specific chemical modification of bacterial type I dehydroquinase--opportunities for drug discovery

Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy.

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues

Synthesis of Polyhydroxycyclohexanes and Relatives from (−)-Quinic Acid†

Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme.

Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase

Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii

Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids

Using surface enhanced Raman scattering to analyze the interactions of protein receptors with bacterial quorum sensing modulators.

β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs