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List of works by Frank Gieseler

"Double reflection": a practical approach to teach patient-doctor communication in oncology

scientific article published on January 2013

A drug-resistant variant of topoisomerase II alpha in human HL-60 cells exhibits alterations in catalytic pH optimum, DNA binding and sub-nuclear distribution.

scientific article published on December 1993

Activated coagulation factors in human malignant effusions and their contribution to cancer cell metastasis and therapy

scientific article published on 01 June 2007

Activation of the coagulation system in cancerogenesis and metastasation

scientific article

Activation of topoisomerase II during partial purification by heparin-Sepharose chromatography

scientific article published on 01 November 1992

Addition of darbepoetin alfa to dose-dense chemotherapy: results from a randomized phase II trial in small-cell lung cancer patients receiving carboplatin plus etoposide

scientific article published in January 2011

Adult mesenchymal stem cells explored in the dental field

scientific article published in January 2013

Ambrisentan, an endothelin receptor type A-selective antagonist, inhibits cancer cell migration, invasion, and metastasis

scientific article published on 28 September 2020

Apoptosis research is saving the reputation of chemotherapy

scientific article published on 01 November 1999

Are topoisomerase II inhibitor-induced micronuclei in vitro a predictive marker for the compounds' ability to cause secondary leukemias after treatment?

scientific article published on 01 January 1999

Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines

scientific article published on 01 November 1999

Cancer Diagnosis: A Trauma for Patients and Doctors Alike

scientific article published on 22 February 2018

Cellular resistance mechanisms with impact on the therapy of multiple myeloma

scientific article published on 01 July 1998

Characterization of spontaneous and TGF-β-induced cell motility of primary human normal and neoplastic mammary cells in vitro using novel real-time technology

scientific article

Clinical importance of P-glycoprotein-related resistance in leukemia and myelodysplastic syndromes--first experience with their reversal

scientific article published in January 1994

Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment

scientific article published in December 2005

Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial

scientific article

Correction: Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal and Neoplastic Mammary Cells In Vitro Using Novel Real-Time Technology

Correlation between the DNA-binding affinity of topoisomerase inhibiting drugs and their capacity to induce hematopoetic cell differentiation.

scientific article

Correlation between the expression of DNA topoisomerases I and IIalpha and clinical parameters in kidney disease

scientific article

Culprit and victim -- DNA topoisomerase II.

scientific article

Cytotoxicity of anthracyclines: correlation with cellular uptake, intracellular distribution and DNA binding

scientific article published on January 1994

Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action

scientific article published on 21 November 2015

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Detection and Quantification of Extracellular Vesicles via FACS: Membrane Labeling Matters!

scientific article published on 31 December 2019

Different functional states of topoisomerase II can be discriminated by orthovanadate sensitivity in multi-drug resistant human leukemic cells

scientific article published on March 1993

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1 ⬇️

scientific article published on May 30, 2011

Differential roles of Src in transforming growth factor-ß regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells.

scientific article published on 11 January 2011

Elevated bladder cancer risk due to colorants--a statewide case-control study in North Rhine-Westphalia, Germany

scientific article published on January 2008

Erratum to: Adult Mesenchymal Stem Cells Explored in the Dental Field

scientific article published in January 2013

Extracellular Vesicles and Cell-Cell Communication: New Insights and New Therapeutic Strategies Not Only in Oncology

scientific article published on 18 June 2020

Extracellular vesicles from malignant effusions induce tumor cell migration: inhibitory effect of LMWH tinzaparin.

scientific article published on 20 July 2016

Germline variations of the topoisomerase IIα gene as risk factors for primary gastric B-cell lymphoma

article

Granulocytic differentiation of HL-60 cells is not regulated by DNA de novo methylation

scientific article published on 01 March 1989

Heterogeneity of microvesicles from cancer cell lines under inflammatory stimulation with TNF-α

scientific article published on 23 August 2018

Idarubicin monotherapy in multiply pretreated leukemia patients: response in relation to P-glycoprotein expression

scientific article published on 01 February 1997

In vitro efficacy of known P-glycoprotein modulators compared to droloxifene E and Z: studies on a human T-cell leukemia cell line and their resistant variants

scientific article

Induction of apoptosis by idarubicin: how important is the plasma peak?

scientific article

Influence of serum protein binding on the uptake and retention of idarubicin by sensitive and multidrug resistant human leukemic cells.

scientific article published on July 1999

Intermittent exposure to doxorubicin in vitro selects for multifactorial non-P-glycoprotein-associated multidrug resistance in RPMI 8226 human myeloma cells.

scientific article published on April 1997

Ionizing radiation induces a motile phenotype in human carcinoma cells in vitro through hyperactivation of the TGF-beta signaling pathway

scientific article published on 4 August 2015

Kinetics of nuclear translocation and turnover of the vitamin D receptor in human HL60 leukemia cells and peripheral blood lymphocytes--coincident rise of DNA-relaxing activity in nuclear extracts

scientific article published on 01 March 1992

Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition.

scientific article

Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon

scientific article

Nuclear Topoisomerase II Activity Changes During HL-60 Leukemic Cell Differentiation: Alterations in Drug Sensitivity and pH Dependency.

scientific article published on January 1991

Obesity and cancer

scientific article

Obesity and cancer

scientific article published on 01 January 2006

PO-18 - Fibronectin EDA/EDB is expressed in adherent SCLC NCI-H69 cells and in pleural effusions of lung cancer patients: possible implication for drug resistance.

scientific article published on 8 April 2016

Pathophysiological considerations to thrombophilia in the treatment of multiple myeloma with thalidomide and derivates.

scientific article

Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β

scientific article published on 23 February 2015

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer

scientific article

Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling.

scientific article published on 22 November 2017

Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact

scientific article

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5.

scientific article published on 17 May 2019

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling

scientific article published on January 2014

Randomized phase III study of gemcitabine and vinorelbine versus gemcitabine, vinorelbine, and cisplatin in the treatment of advanced non-small-cell lung cancer: from the German and Swiss Lung Cancer Study Group

scientific article

Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer

scientific article

Repair of idarubicin-induced DNA damage: a cause of resistance?

scientific article published on 5 July 2007

Resistance mechanisms of gastrointestinal cancers: why does conventional chemotherapy fail?

scientific article

Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer.

scientific article published on 24 May 2018

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility.

scientific article published on 20 December 2017

The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors

scientific article published on May 2011

The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells

scientific article

The dilemma of gastroenterological oncology: we know a lot but we still achieve too little

scientific article published in April 2000

Tissue factor activity on microvesicles from cancer patients

scientific article published on 16 November 2019

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

scientific article published on 09 April 2015

Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells

scientific article

Topoisomerase II function detected as protein-DNA complexes in two sublines of HL-60 cells.

scientific article

Topoisomerase activities in undifferentiated acute myeloblastic leukemias and monocytic differentiated leukemias

scientific article published on 01 January 1997

Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling.

scientific article

Use of anion-exchange chromatography and chromatofocusing to reveal the structural and functional heterogeneity of topoisomerase II in a HL-60 cell line resistant to multi-drug treatment

scientific article published on 01 November 1991

Using annexin V-coated magnetic beads to capture active tissue factor-bearing microparticles from body fluids

scientific article published on 27 November 2013

[A 40-year-old patient with diffuse pain in the lower backbone].

scientific article

[Acute airway obstruction in acquired hemophilia A]

scientific article published on 01 May 2005

[Diagnosis and treatment of rectal cancer]

scientific article published on 01 October 2010

[Obesity and cancer]

scientific article published on 01 February 2015

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