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List of works by Sherwin Sy

A Markov chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation.

scientific article published on 30 August 2013

A mathematical model-based analysis of the time-kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa

scientific article published on 3 February 2018

A model-based analysis of pharmacokinetic-pharmacodynamic (PK/PD) indices of avibactam against Pseudomonas aeruginosa

scientific article published on 28 October 2018

A perspective on the toxicological mechanisms possibly contributing to the failure of oral glycoprotein IIb/IIIa antagonists in the clinic

scientific article (publication date: 2004)

Application of Pharmacometric Analysis in the Design of Clinical Pharmacology Studies for Biosimilar Development.

scientific article published on 7 March 2018

Application of Trial Simulation in the Design of a Prospective Study for Concentration-QTc Analysis in Support of a Thorough QT Study Waiver

scientific article published on 02 August 2020

Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of <i>Escherichia coli and Klebsiella pneumoniae</i> harbouring serine- and New Delhi metallo-β-lactamases

scientific article published in 2021

Change in topoisomerase 1 (Top1) positive circulating tumor cells impacts overall survival in patients with advanced breast cancer after treatment with etirinotecan pegol.

scientific article published on 4 April 2018

Clinical Pharmacokinetics and Pharmacodynamics of Ceftazidime-Avibactam Combination: A Model-Informed Strategy for its Clinical Development

scientific article published on 01 May 2019

Dermal pharmacokinetics of pyrazinamide determined by microdialysis sampling in rats

scientific article published on 12 October 2017

Dose Optimization of Moxifloxacin and Linezolid Against Tuberculosis Using Mathematical Modeling and Simulation

scientific article published on 29 October 2018

Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model

scientific article published on 19 January 2015

Estimation of intracellular concentration of stavudine triphosphate in HIV-infected children given a reduced dose of 0.5 milligrams per kilogram twice daily

scientific article published on 02 December 2013

Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration.

scientific article

Evaluation of in vitro synergy between vertilmicin and ceftazidime against Pseudomonas aeruginosa using a semi-mechanistic pharmacokinetic/pharmacodynamic model.

scientific article published on November 2014

Experimental design and modeling approach to evaluate efficacy of β-lactam/β-lactamase inhibitor combinations

scientific article

Fixed-dose combinations: a potential means to boost drug development for selected drugs

scientific article published on 13 November 2017

Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model

scientific article published on 24 December 2015

In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.

scientific article

In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms

scientific article published on 21 April 2016

Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients.

scientific article

Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors.

scientific article published on 21 March 2018

Largazole pharmacokinetics in rats by LC-MS/MS.

scientific article published on 20 March 2014

Learning and augmenting natural processes: potential means of combating antimicrobial resistance from a drug R&D perspective

scientific article published on 06 September 2019

Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression

scientific article published on 13 July 2002

Mulitvariate cluster analysis of a human hepatic cytochrome P450 database.

scientific article published in November 2002

N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis

scientific article published on 11 May 2015

Pharmacodynamic Attainment of the Synergism of Meropenem and Fosfomycin Combination against Pseudomonas aeruginosa Producing Metallo-β-Lactamase

scientific article published on 24 May 2019

Pharmacodynamic Effects of Sulbactam/Meropenem/Polymyxin-B Combination Against Extremely Drug Resistant Acinetobacter baumannii Using Checkerboard Information

scientific article published on 19 June 2019

Pharmacodynamic Evaluation of Fosfomycin against Escherichia coli and Klebsiella spp. from Urinary Tract Infections and the Influence of pH on Fosfomycin Activities

scientific article published on 12 June 2017

Pharmacodynamic Evaluation of the Potential Clinical Utility of Fosfomycin and Meropenem in Combination Therapy against KPC-2-Producing Klebsiella pneumoniae

scientific article published on 02 May 2016

Pharmacokinetic evaluation of avicularin using a model-based development approach

scientific article published on 17 March 2015

Pharmacokinetics and pharmacodynamics in antibiotic dose optimization.

scientific article

Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis

scientific article

Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii

scientific article published on 22 January 2020

Physiologically-based pharmacokinetic-pharmacodynamic evaluation of meropenem plus fosfomycin in pediatrics

scientific article published on 07 July 2020

Physiologically-based pharmacokinetics of ziprasidone in pregnant women

scientific article published on 11 March 2019

Population Pharmacokinetic and Covariate Analysis of Apatinib, an Oral Tyrosine Kinase Inhibitor, in Healthy Volunteers and Patients with Solid Tumors

scientific article published on 5 July 2016

Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

scientific article published on 11 March 2011

Potentiation of ceftazidime by avibactam against β-lactam-resistant Pseudomonas aeruginosa in an in vitro infection model

scientific article published on 10 January 2017

Predicting pediatric age-matched weight and body mass index

scientific article

Prediction of in vivo and in vitro infection model results using a semimechanistic model of avibactam and aztreonam combination against multidrug resistant organisms

scientific article published on February 2017

Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.

scientific article

Rapid and efficient method for the quantification of lychnopholide in rat plasma by liquid chromatography-tandem mass spectrometry for pharmacokinetic application

scientific article published on 17 November 2015

Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers

scientific article (publication date: July 2002)

Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model

scientific article published on 28 July 2015

Simultaneous quantification of seven active metabolites of roxifiban in human plasma by LC/MS/MS in the presence of an interfering displacer at millimolar concentrations

scientific article published on 01 April 2003

The use of roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease

scientific article

Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk.

scientific article published on 20 February 2008

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