Search filters

List of works by Christopher Overall

A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis

scientific article

A decline in transcript abundance for Heterodera glycines homologs of Caenorhabditis elegans uncoordinated genes accompanies its sedentary parasitic phase

scientific article published on 19 April 2007

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

scientific journal article

A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products

scientific article

A time-course comparative microarray analysis of an incompatible and compatible response by Glycine max (soybean) to Heterodera glycines (soybean cyst nematode) infection

scientific article

Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice

scientific article published on 10 March 2008

Absolute proteomic quantification of the activity state of proteases and proteolytic cleavages using proteolytic signature peptides and isobaric tags.

scientific article

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

scientific article

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

scientific article published on 22 September 2015

Advances in the Chromosome-Centric Human Proteome Project: looking to the future

scientific article published on 17 October 2017

Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases

scientific article published on 17 June 2017

Amino-Terminal Oriented Mass Spectrometry of Substrates (ATOMS) N-terminal sequencing of proteins and proteolytic cleavage sites by quantitative mass spectrometry

scientific article

Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σ(E)-regulated SPI-2 gene expression

scientific article

Analysis of the degradome with the CLIP-CHIP microarray

scientific article

Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome

scientific article

ArrayInitiative - a tool that simplifies creating custom Affymetrix CDFs ⬇️

scientific article

BBGD: an online database for blueberry genomic data

scientific article

Bayesian Model Averaging for Ensemble-Based Estimates of Solvation-Free Energies

scientific article published on 14 December 2016

Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16.

scientific article

Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities

scientific article

Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation

scientific article

Broad coverage identification of multiple proteolytic cleavage site sequences in complex high molecular weight proteins using quantitative proteomics as a complement to edman sequencing

scientific article

CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection

scientific article

CLIPPER: an add-on to the Trans-Proteomic Pipeline for the automated analysis of TAILS N-terminomics data

scientific article

CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy

scientific article

Can we predict protein from mRNA levels?

scientific article published in July 2017

Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts.

scientific article

Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A).

scientific article published on May 2007

Cell-based identification of natural substrates and cleavage sites for extracellular proteases by SILAC proteomics

scientific article published in January 2009

ChIP-Seq Analysis of the σE Regulon of Salmonella enterica Serovar Typhimurium Reveals New Genes Implicated in Heat Shock and Oxidative Stress Response.

scientific article published on 21 September 2015

Chapter 13. Characterizing proteolytic processing of chemokines by mass spectrometry, biochemistry, neo-epitope antibodies and functional assays

scientific article

Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays

scientific article

Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in c

scientific article published on 02 August 2004

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry.

scientific article

Chemokine monocyte chemoattractant protein-3 in progressive periodontal lesions in patients with chronic periodontitis

scientific article published on 01 February 2010

Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries

scientific article

Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage

scientific article

Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice

scientific article published in Journal of Biological Chemistry

Corrigendum to “Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8” [FEBS Lett. 582 (2008) 819-825]

scholarly article published in FEBS Letters

Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts

scientific article

Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines

scientific article published on April 2015

Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology

scientific article published on 08 January 2009

Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2).

scientific article published on 25 July 2016

Degradomics: systems biology of the protease web. Pleiotropic roles of MMPs in cancer

scientific article

Developing a systems biology approach to study disease progression caused by Heterodera glycines in Glycine max

scientific article

Development of soluble ester-linked aldehyde polymers for proteomics.

scientific article

Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences

scientific article published on 06 March 2007

Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter

scientific article published in November 2004

Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics

scientific article

Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical.

scientific article

Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease.

scientific article

Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

scientific article published on October 2008

Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites

scientific article

Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity

scientific article

Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing.

scientific article published on June 2006

Global analysis of Salmonella alternative sigma factor E on protein translation.

scientific article published on 27 February 2015

HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration

scientific article published on 21 September 2003

Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection

scientific article published on 29 April 2015

Highlight: Frontiers in Proteolysis

scientific article published on 01 November 2018

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

scientific article published on 23 February 2017

Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 2.1.

scientific article

Human and mouse proteases: a comparative genomic approach

scientific article (publication date: July 2003)

Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis.

scientific article

Identification of Protease Cleavage Sites and Substrates in Cancer by Carboxy-TAILS (C-TAILS).

scientific article published in January 2018

Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Conne

scientific article

Identification of cellular MMP substrates using quantitative proteomics: isotope-coded affinity tags (ICAT) and isobaric tags for relative and absolute quantification (iTRAQ).

scientific article published in January 2010

Identification of proteolytic products and natural protein N-termini by Terminal Amine Isotopic Labeling of Substrates (TAILS)

scientific article published on 01 January 2011

Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets

scientific article

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

scientific article

Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism

scientific article published on 21 March 2013

In search of partners: linking extracellular proteases to substrates

scientific article published on 14 February 2007

In situ extension as an approach for identifying novel alpha-amylase inhibitors

scientific article published on 10 August 2004

Integrated in silico Analyses of Regulatory and Metabolic Networks of Synechococcus sp. PCC 7002 Reveal Relationships between Gene Centrality and Essentiality

scientific article published on 27 March 2015

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

scientific article

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity

scientific article

Laser capture microdissection (LCM) and comparative microarray expression analysis of syncytial cells isolated from incompatible and compatible soybean (Glycine max) roots infected by the soybean cyst nematode (Heterodera glycines).

scientific article

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

scientific article published on 28 September 2003

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification

scientific article published on 24 November 2014

Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis

scientific article published on 9 October 2014

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

scientific article

Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency

scientific article published on 12 March 2002

Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression

scientific article

Matrix metalloproteinase processing of CXCL11/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding

scientific article

Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo

scientific article published on August 2002

Matrix metalloproteinase processing of signaling molecules to regulate inflammation

scientific article published on October 2013

Matrix metalloproteinase proteomics: substrates, targets, and therapy.

scientific article published on 16 July 2009

Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro

scientific article published on 13 June 2008

Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics

scientific article published on October 2009

Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids

scientific article

Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase

article

Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates

scientific article

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates

scientific article published on 26 April 2004

Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage

scientific journal article

Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

scientific article published on 02 July 2008

Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo

scientific article

Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength

scientific article published on 12 August 2013

Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications

scientific article published on 03 August 2016

Microarray Detection Call Methodology as a Means to Identify and Compare Transcripts Expressed within Syncytial Cells from Soybean (Glycine max) Roots Undergoing Resistant and Susceptible Reactions to the Soybean Cyst Nematode (Heterodera glycines).

scientific article

Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis

scientific article

Missing the target: matrix metalloproteinase antitargets in inflammation and cancer

scientific article published on 26 March 2013

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites

scientific article

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

scientific article

Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics

scientific article

N- and C-terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification

scientific article published on 07 December 2011

Network analyses reveal pervasive functional regulation between proteases in the human protease web

scientific article (publication date: May 2014)

Network analysis of transcriptomics expands regulatory landscapes in Synechococcus sp. PCC 7002.

scientific article published on 27 August 2016

New intracellular activities of matrix metalloproteinases shine in the moonlight

scientific article

Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human.

scientific article

Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP-9 secretion

scientific article published on 22 April 2016

Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

scientific article published on 20 August 2010

Opposite Electron-Transfer Dissociation and Higher-Energy Collisional Dissociation Fragmentation Characteristics of Proteolytic K/R(X)n and (X)nK/R Peptides Provide Benefits for Peptide Sequencing in Proteomics and Phosphoproteomics

scientific article published on 2 December 2016

Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: Organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the CLIP-CHIP™ DNA microarray

scientific article

Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding

scientific article published on 27 May 2008

Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond

scientific article published on 8 November 2004

Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger

scientific article published on 24 August 2007

Positional proteomics in the era of the human proteome project on the doorstep of precision medicine

scientific article

Prediction of bacterial E3 ubiquitin ligase effectors using reduced amino acid peptide fingerprinting.

scientific article published on 7 June 2019

Prediction of multi-drug resistance transporters using a novel sequence analysis method.

scientific article published on 9 March 2015

Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase

scientific article

Progress and Future Direction of Chromosome-Centric Human Proteome Project

scientific article published in December 2017

Progress in the Chromosome-Centric Human Proteome Project as Highlighted in the Annual Special Issue IV.

scientific article

Protease degradomics: a new challenge for proteomics

scientific article

Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors

scientific article

Protease proteomics: revealing protease in vivo functions using systems biology approaches

scientific article published on May 2008

Protease research in the era of systems biology.

scientific article published on November 2007

Protease specificity profiling by tandem mass spectrometry using proteome-derived peptide libraries

scientific article

Protease yoga: extreme flexibility of a matrix metalloproteinase

scientific article published on 01 October 2007

Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions

scientific article

Protein TAILS: when termini tell tales of proteolysis and function

scientific article

Protein Termini and Their Modifications Revealed by Positional Proteomics

scientific article

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.

scientific article

Proteolytic host cell enzymes in gingival crevice fluid

scientific article

Proteolytic post-translational modification of proteins: proteomic tools and methodology

scientific article published on 25 July 2013

Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration

scholarly article

Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre- and post-translational events.

scientific article

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

scientific article

Proteome-wide analysis of protein carboxy termini: C terminomics

scientific article published on 6 June 2010

Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids

scientific article published on 16 September 2013

Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates

scientific article

Proteomic discovery of protease substrates

scientific article

Proteomic identification of cellular protease substrates using isobaric tags for relative and absolute quantification (iTRAQ).

scientific article

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting

scientific article published on December 2009

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen

scientific article

Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome.

scientific article published in January 2007

Recent Advances in the Chromosome-Centric Human Proteome Project: Missing Proteins in the Spot Light

article

Regulation of intercellular adhesion strength in fibroblasts

scientific article published on 6 July 2004

Site specific cleavage mediated by MMPs regulates function of agrin.

scientific article published on 11 September 2012

Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites.

scientific article

Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer

scientific article

Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8

scientific article

Stromal regulation of vessel stability by MMP14 and TGFbeta

scientific article

Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase

scientific article

Structure of the Mycosin-1 Protease from the Mycobacterial ESX-1 Protein Type VII Secretion System

scientific article

Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation

scientific article published on 15 January 2013

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors

scientific article published on 27 July 2016

TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains

scientific article

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

scientific article published on 17 March 2011

The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays

scientific article

The Pacific Northwest National Laboratory library of bacterial and archaeal proteomic biodiversity

scientific article

The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily

scientific article published on 19 January 2004

The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.

scientific article

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases

scientific article published on 31 August 2005

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

scientific article

The path of no return--Truncated protein N-termini and current ignorance of their genesis

scientific article

The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human.

scientific article

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

scientific article

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

scientific article published on September 2012

TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function ⬇️

scientific article published on November 18, 2011

TopFIND, a knowledgebase linking protein termini with function

scientific article published on 7 August 2011

Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice

scientific article published on 14 August 2008

Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration

scientific article published on 7 September 2016

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

scientific article

Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics

scientific article

Paulina is supported by:

About Paulina

Help