List of works - Rachel Lennon

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

scientific article published in Nature Communications

A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations

scientific article published on 18 May 2022

A fair reason for failing to thrive

scientific article published on 01 April 2008

A role for OCRL in glomerular function and disease

scientific article published on 06 December 2019

ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder.

scientific article published in December 2017

Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome

scientific article

Alport Syndrome in Women and Girls.

scientific article published on 10 June 2016

An inducible mouse model of podocin-mutation-related nephrotic syndrome

scientific article published on 19 October 2017

Applying Proteomics to Investigate Extracellular Matrix in Health and Disease

scientific article

Autoantigens PLA2R and THSD7A in membranous nephropathy share a common epitope motif in the N-terminal domain

scientific article published on 05 August 2019

Basement Membrane Defects in Genetic Kidney Diseases.

scientific article published on 29 January 2018

Basement membrane ligands initiate distinct signalling networks to direct cell shape

scientific article published on 06 March 2020

Be on alert for pediatric AKI.

scientific article published on August 2017

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease

scientific article

Complexities of the glomerular basement membrane

scientific article published on 24 August 2020

ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

scientific article published on February 2016

Engineered basement membranes: from in vivo considerations to cell-based assays

scientific article published on 01 November 2018

Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils.

scientific article

Establishment of conditionally immortalized human glomerular mesangial cells in culture, with unique migratory properties.

scientific article published on 8 June 2011

From podocyte biology to novel cures for glomerular disease

scientific article published on 31 May 2019

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors

scientific article published on 7 February 2018

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization

scientific article

Genetic Disorders of the Glomerular Filtration Barrier

scientific article published on 23 March 2020

Genetic testing in steroid-resistant nephrotic syndrome: why, who, when and how?

scientific article published on 27 November 2017

Global analysis reveals the complexity of the human glomerular extracellular matrix

scientific article published on 16 January 2014

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

scientific article published on 17 March 2021

Glomerular cell cross-talk influences composition and assembly of extracellular matrix

scientific article published on 16 January 2014

Glomerular cell crosstalk.

scientific article published on 26 March 2016

Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1

scientific article published on 27 July 2017

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes

scientific article

Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy

scientific article published on 6 October 2014

Intravenous methylprednisolone in idiopathic childhood nephrotic syndrome

scientific article published on 27 January 2010

Kidney organoids recapitulate human basement membrane assembly in health and disease

scientific article published on 25 January 2022

Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes

scientific article published on 01 April 2007

Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes

scientific article

PLA2R binds to the annexin A2-S100A10 complex in human podocytes.

scientific article published on 31 July 2017

Pinpointing clinical diagnosis through whole exome sequencing to direct patient care: a case of Senior-Loken syndrome

scientific article published in The Lancet

Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis

scientific article published on 22 September 2004

Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.

scientific article published on 29 August 2017

Proteomic definitions of basement membrane composition in health and disease

scientific article

Recent developments in the detection and management of acute kidney injury

scientific article

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.

scientific article

Should We Increase GFR with Bardoxolone in Alport Syndrome?

scientific article published on 25 January 2018

Support for studies in paediatric medicine is needed.

scientific article published on November 2000

The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology

scientific article

The human glomerular podocyte is a novel target for insulin action

scientific article published on November 2005

The importance of clinician, patient and researcher collaborations in Alport syndrome

scientific article published on 01 May 2019

The importance of podocyte adhesion for a healthy glomerulus

scientific article

The myriad possibility of kidney organoids

scientific article published on 01 May 2019

The non-immunosuppressive management of childhood nephrotic syndrome

scientific article

Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury.

scientific article

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions

scientific article

Towards a biomarker panel for the assessment of AKI in children receiving intensive care

scientific article

Vinculin is required to maintain glomerular barrier integrity

scientific article published on 11 December 2017

List of works by Rachel Lennon

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations

A fair reason for failing to thrive

A role for OCRL in glomerular function and disease

ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder.

Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome

Alport Syndrome in Women and Girls.

An inducible mouse model of podocin-mutation-related nephrotic syndrome

Applying Proteomics to Investigate Extracellular Matrix in Health and Disease

Autoantigens PLA2R and THSD7A in membranous nephropathy share a common epitope motif in the N-terminal domain

Basement Membrane Defects in Genetic Kidney Diseases.

Basement membrane ligands initiate distinct signalling networks to direct cell shape

Be on alert for pediatric AKI.

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease

Complexities of the glomerular basement membrane

ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

Engineered basement membranes: from in vivo considerations to cell-based assays

Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils.

Establishment of conditionally immortalized human glomerular mesangial cells in culture, with unique migratory properties.

From podocyte biology to novel cures for glomerular disease

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization

Genetic Disorders of the Glomerular Filtration Barrier

Genetic testing in steroid-resistant nephrotic syndrome: why, who, when and how?

Global analysis reveals the complexity of the human glomerular extracellular matrix

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

Glomerular cell cross-talk influences composition and assembly of extracellular matrix

Glomerular cell crosstalk.

Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes

Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy

Intravenous methylprednisolone in idiopathic childhood nephrotic syndrome

Kidney organoids recapitulate human basement membrane assembly in health and disease

Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes

Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes

PLA2R binds to the annexin A2-S100A10 complex in human podocytes.

Pinpointing clinical diagnosis through whole exome sequencing to direct patient care: a case of Senior-Loken syndrome

Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis

Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.

Proteomic definitions of basement membrane composition in health and disease

Recent developments in the detection and management of acute kidney injury

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.

Should We Increase GFR with Bardoxolone in Alport Syndrome?

Support for studies in paediatric medicine is needed.

The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology

The human glomerular podocyte is a novel target for insulin action

The importance of clinician, patient and researcher collaborations in Alport syndrome

The importance of podocyte adhesion for a healthy glomerulus

The myriad possibility of kidney organoids

The non-immunosuppressive management of childhood nephrotic syndrome

Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury.

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions

Towards a biomarker panel for the assessment of AKI in children receiving intensive care

Vinculin is required to maintain glomerular barrier integrity