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List of works by Emmanuel Brouillet

1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.

scientific article

3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

scientific article

A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.

scientific article published in June 2003

A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo

scientific article published in November 2004

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

scientific article published on 29 May 2013

A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo.

scientific article published in November 2001

Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults.

scientific article

Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition

scientific article

Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.

scientific article published in January 1993

Age‐Dependent Striatal Excitotoxic Lesions Produced by the Endogenous Mitochondrial Inhibitor Malonate ⬇️

scientific article published on September 1, 1993

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

scientific article

Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10.

scientific article published on August 1994

Animal models of Huntington's disease: from basic research on neuronal death to assessment of new therapeutic strategies

scientific article published in October 2000

Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo

scientific article

Anticonvulsant activity of the diaryltriazine, LY81067: studies using electroencephalographic recording and positron emission tomography

scientific article published in April 1989

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

scientific article

Benzodiazepine receptors studied in living primates by positron emission tomography: antagonist interactions

scientific article published on 01 August 1988

Benzodiazepine receptors studied in living primates by positron emission tomography: inverse agonist interactions

scientific article published on 01 June 1987

Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss

scientific article published in July 1993

Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation.

scientific article published on 29 March 2006

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity.

scientific article published in April 2006

Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease.

scientific article published in June 2003

Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease.

scientific article published on August 2009

Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo

scientific article published on 24 February 2012

Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease

scientific article published in May 1996

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

scientific article

Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration.

scientific article published on 16 December 2009

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

scientific article

Complementarity of gluCEST and 1 H-MRS for the study of mouse models of Huntington's disease

scientific article published on 21 March 2020

Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

scientific article published on 18 February 2020

Correction: IRC-082451, a Novel Multitargeting Molecule, Reduces L-DOPA-Induced Dyskinesias in MPTP Parkinsonian Primates

scientific article (publication date: 30 January 2013)

Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration

scientific journal article

Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

scientific article

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article

Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms

scientific article published in February 2004

Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy.

scientific article published in August 2002

Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity in vivo

scientific article published on 25 February 2019

Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics

scientific article published on 21 January 2009

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

scientific article published on 11 February 2008

Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia.

scientific article published in October 2009

Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid

scientific article published on 01 May 2000

Early alterations of brain cellular energy homeostasis in Huntington disease models

journal article published in 2012

Ectosomes: a new mechanism for non-exosomal secretion of tau protein

scientific article

Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate

scientific article

Effects of unilateral lesion of the nucleus basalis of Meynert on brain glucose utilization in callosotomized baboons: a PET study

scientific article published in September 1990

Energy defects in Huntington's disease: Why "in vivo" evidence matters.

scientific article

Engineered lentiviral vector targeting astrocytes in vivo

scientific article

Evidence for a "metabolically inactive" inorganic phosphate pool in adenosine triphosphate synthase reaction using localized 31P saturation transfer magnetic resonance spectroscopy in the rat brain at 11.7 T.

scientific article published on 28 June 2016

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

scientific article

Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease

scientific article published in August 1998

Glutamate receptor binding sites in MPTP-treated mice.

scientific article published in June 1993

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

scientific article

High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.

scientific article

IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats

scientific article

IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates

scientific article

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions

scientific article

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

scientific article published on 01 March 2020

Implication of the JNK pathway in a rat model of Huntington's disease

scientific article

In vivo benzodiazepine receptor occupancy by CL 218,872 visualized by positron emission tomography in the brain of the living baboon: modulation by GABAergic transmission and relation with anticonvulsant activity ⬇️

scientific article published on January 1, 1991

In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates

scientific article published in August 1991

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

scientific article published on 12 August 2003

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

scientific article

In vivo high intrinsic efficacy of triazolam: a positron emission tomography study in nonhuman primates

scientific article

In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease.

scientific article published on 15 June 2016

In vivo interactions of pentylenetetrazole with benzodiazepine receptors: lack of direct correlation between benzodiazepine receptor occupancy and convulsant potency of this drug

scientific article

In vivo metabolites of N omega-nitro-L-arginine methyl ester: methanol and N omega-nitro-L-arginine

scientific article published on 01 December 1995

In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis

scientific article published in February 1997

In vivo visualization of central muscarinic receptors using [11C]quinuclidinyl benzilate and positron emission tomography in baboons

scientific article published in March 1992

Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase

scientific article published in March 1999

Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons

scientific article published in September 1996

Insulin growth factor-1 protects against excitotoxicity in the rat striatum

scientific article published in October 2004

Interaction of suriclone with central type benzodiazepine receptors in living baboons

scientific article published in January 1990

Intracellular metabolites in the primate brain are primarily localized in long fibers rather than in cell bodies, as shown by diffusion-weighted magnetic resonance spectroscopy.

scientific article

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

scientific article

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

scientific article

Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: implications for neuroprotection studies

scientific article published in January 2000

Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism

scientific article published on 01 March 1993

Minocycline in phenotypic models of Huntington's disease

scientific article published in February 2005

Mitochondria in Huntington's disease

scientific article published on 11 August 2009

Modeling analysis of [11C]flumazenil kinetics studied by PET: application to a critical study of the equilibrium approaches.

scientific article published on May 1993

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease

scientific article published on 16 October 2018

Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis

scholarly article

Mutant huntingtin alters Tau phosphorylation and subcellular distribution

scientific article published on 20 August 2014

NMDA antagonists partially protect against MPTP induced neurotoxicity in mice

scientific article published on 01 April 1993

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

scientific article published on 01 October 1993

Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy).

scientific article published on 23 May 2003

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

scientific article

Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain.

scientific article published in October 2005

New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo

scientific article published on 25 May 2016

Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging

scientific article published on May 1996

Normal aging modulates the neurotoxicity of mutant huntingtin

scientific article

Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates

scientific article published on 20 February 2018

Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat.

scientific article

Pentylenetetrazol-induced seizure is not mediated by benzodiazepine receptors in vivo

scientific article published on 01 October 1987

Perseverative behavior underlying attentional set-shifting deficits in rats chronically treated with the neurotoxin 3-nitropropionic acid.

scientific article

Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease

scientific article

Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo.

scientific article published in October 2004

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

scientific article published on 11 July 2005

Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.

scientific article

Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid

scientific article published in July 1997

Quantitative assessment of transcriptome differences between brain territories

scientific article

Quantitative evaluation of benzodiazepine receptors in live Papio papio baboons using positron emission tomography

scientific article published in October 1990

Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models

scientific article published on 5 February 2008

Relationships between benzodiazepine receptors, impairment of GABAergic transmission and convulsant activity of beta-CCM: a PET study in the baboon Papio papio

scientific article published in January 1991

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.

scientific article

Restricted transgene expression in the brain with cell-type specific neuronal promoters

scientific article

Restricted transgene expression in the brain with cell-type specific neuronal promoters

Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats

scientific article published in November 1997

Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration

scientific article published in July 1997

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients

scientific article published on 5 November 2013

Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid.

scientific article

Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

scientific article published on 22 March 2010

Status epilepticus induced by pentylenetetrazole modulates in vivo [11C]Ro 15-1788 binding to benzodiazepine receptors. Effects of ligands acting at the supramolecular receptor complex

scientific article

Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease

scientific article

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

scientific article

Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo

scientific article

Sustained effects of nonallele-specific Huntingtin silencing

scientific article published on March 2009

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.

scientific article published on 25 November 2015

Synthesis and in vivo distribution of no-carrier-added N(omega)-Nitro-L-arginine [11C]methyl ester, a nitric oxide synthase inhibitor

scientific article published on 01 May 1996

Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism

scientific article published on 01 October 1994

The 3-NP Model of Striatal Neurodegeneration

scientific article published on 10 April 2014

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

scientific article published on 09 October 2019

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

scientific article published on February 2015

The Nrf2 pathway as a potential therapeutic target for Huntington disease A commentary on "Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington di

scientific article published on 24 April 2010

The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-Jun N-terminal kinase/c-Jun module.

scientific article published in March 2002

The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study

scientific article

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

scientific article published on 9 March 2018

The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease

scientific article published on 24 October 2018

Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon

scientific article published in March 1996

What is gained or 'lost in translation' in Huntington's disease

scientific article published on 01 October 2019

Zolpidem displays heterogeneity in its binding to the nonhuman primate benzodiazepine receptor in vivo.

scientific article published in October 1995

[Logistical regression of success factors in the former internship examination for medical students]

scientific article published on 01 June 2005

[Study of specific binding sites of benzodiazepines using positron emission tomography in live baboons (Papio papio)]

scientific article published on 01 September 1987

pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study.

scientific article

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