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List of works by Halina Machelska

A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors

scientific article published on 29 October 2020

A nontoxic pain killer designed by modeling of pathological receptor conformations

scientific article

A stomatin-domain protein essential for touch sensation in the mouse

scientific article published on 13 December 2006

Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides

scientific article published on 07 October 2016

Advances in Achieving Opioid Analgesia Without Side Effects

scientific article published on 29 November 2018

Analgesic and antiinflammatory effects of two novel kappa-opioid peptides

scientific article

Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain

Analysis of potassium and calcium imaging to assay the function of opioid receptors.

scientific article published in January 2015

Antinociception after both peripheral and intrathecal injection of oxotremorine is modulated by spinal nitric oxide

scientific article published on 01 March 1999

Antinociceptive effects of isoleucine derivatives of deltorphin I and deltorphin II in rat spinal cord: a search for selectivity of delta receptor subtypes

scientific article published on 01 December 1998

Attacking pain at its source: new perspectives on opioids

scientific article (publication date: August 2003)

Author Correction: pKa of opioid ligands as a discriminating factor for side effects

scientific article published on 04 March 2020

Breaking the pain barrier

Chronic morphine increases biosynthesis of nitric oxide synthase in the rat spinal cord

scientific article published on 01 August 1997

Co-expression of beta-endorphin with adhesion molecules in a model of inflammatory pain

scientific article published in August 2000

Comment on "Neutrophils: are they hyperalgesic or anti-hyperalgesic?"

scientific article published in October 2006

Control of Neuropathic Pain by Immune Cells and Opioids ⬇️

scientific article published on August 1, 2011

Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells

scientific article published in December 2004

Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy

scientific article published on 2 November 2012

Different mechanisms of intrinsic pain inhibition in early and late inflammation

scientific article published in August 2003

Differential effects of intrathecally and intracerebroventricularly administered nitric oxide donors on noxious mechanical and thermal stimulation

scientific article published in November 1998

Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain

scientific article published on 8 September 2016

Dual Peripheral Actions of Immune Cells in Neuropathic Pain ⬇️

scientific article published on January 14, 2011

Effects of pentylenetetrazol kindling on glutamate receptor genes expression in the rat hippocampus

scientific article published in March 1998

Effects of pilocarpine and kainate-induced seizures on N-methyl-D-aspartate receptor gene expression in the rat hippocampus

scientific article published in June 1997

Electrophysiological patch clamp assay to monitor the action of opioid receptors

scientific article published in January 2015

Endogene Opioide: Ihre Wirkung kann man deutlich verstärken - Nachgehakt bei Prof. Dr. Halina Machelska und Prof. Dr. Christoph Stein

Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression

scientific article

Functional evidence of pain control by the immune system.

scientific article

IL-4 induces M2 macrophages to produce sustained analgesia via opioids

scientific article published on 27 February 2020

Immune System, Pain and Analgesia

Immune cell-derived opioids protect against neuropathic pain in mice

scientific article published on 12 January 2009

Immune cell-mediated opioid analgesia

scientific article published on 16 August 2020

Immune mechanisms in pain control

scientific article

Immune-derived Opioids: Production and Function in Inflammatory Pain

article

Immunohistochemical Analysis of Opioid Receptors in Peripheral Tissues

scientific article published on 01 January 2021

Immunohistochemical analysis of opioid receptors in peripheral tissues

scientific article published in January 2015

Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain

scientific article published in May 2002

Impaired nociception and peripheral opioid antinociception in mice lacking both kinin B1 and B2 receptors

scientific article published in February 2012

Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice

article

Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord

scientific article published in August 1997

Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord

scientific article published on 01 January 1993

Intracerebroventricular galanin and N-terminal galanin fragment enhance the morphine-induced analgesia in the rat

article

Intrathecal Oxotremorine Affects Formalin-Induced Behavior and Spinal Nitric Oxide Synthase Immunoreactivity in Rats

scientific article published on 01 March 1999

Involvement of the nitric oxide pathway in nociceptive processes in the central nervous system in rats

Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse

scientific article published on December 1994

Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats

scientific article

L-Nitroarginine methyl ester attenuates the development of morphine tolerance and dependence in mice

article

Leukocyte opioid receptors mediate analgesia via Ca(2+)-regulated release of opioid peptides

scientific article

Leukocyte-derived opioid peptides and inhibition of pain

scientific article published on March 2006

Mobilization of opioid-containing polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain

scientific article

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy ⬇️

scientific article published on December 1, 2011

Modulation of morphine and cocaine effects by inhibition of nitric oxide synthase

Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons - Effects of Nerve Injury

scientific article published on 19 December 2018

Nitric oxide synthase inhibitor L-NAME prevents amphetamine-induced prodynorphin gene expression in the rat.

scientific article published in October 1996

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control

scientific article published on 04 March 2020

Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1

scientific journal article

Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain.

scientific article

Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist.

scientific article

Opioids and TRPV1 in the peripheral control of neuropathic pain--Defining a target site in the injured nerve.

scientific article published on 7 October 2015

Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis

scientific article published on 10 December 2019

Pain control and the immune system

Pain control in inflammation governed by selectins

article published in 1998

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

scientific article

Patch Clamp Analysis of Opioid-Induced Kir3 Currents in Mouse Peripheral Sensory Neurons Following Nerve Injury

scientific article published on 01 January 2021

Peripheral Neuroimmune Interactions and Neuropathic Pain

Peripheral Opioid Analgesia Neuroimmune Interactions and Therapeutic Implications

Peripheral analgesic and anti-inflammatory effects of opioids — neuro-immune crosstalk

Peripheral analgesic and antiinflammatory effects of opioids

scientific article published in December 2001

Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study

scientific article published in November 2009

Peripheral antinociceptive effects of exogenous and immune cell-derived endomorphins in prolonged inflammatory pain.

scientific article published in April 2006

Peripheral effects of the kappa-opioid agonist EMD 61753 on pain and inflammation in rats and humans.

scientific article published in July 1999

Peripheral nociceptive integration

Peripheral non-viral MIDGE vector-driven delivery of beta-endorphin in inflammatory pain

scientific article published on 14 December 2009

Peripheral opioid analgesia.

scientific article

Polyglycerol-opioid conjugate produces analgesia devoid of side effects

scientific article

Real-Time Quantitative Reverse Transcription PCR for Detection of Opioid Receptors in Immune Cells

scientific article published on 01 January 2021

Recent advances in understanding neuropathic pain: glia, sex differences, and epigenetics

scientific article

Relative contribution of peripheral versus central opioid receptors to antinociception

scientific article

Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain

scientific article published on 24 May 2004

Skin-nerve preparation to assay the function of opioid receptors in peripheral endings of sensory neurons

scientific article published in January 2015

Stronger antinociceptive efficacy of opioids at the injured nerve trunk than at its peripheral terminals in neuropathic pain

scientific article published on 2 July 2013

T lymphocytes containing β-endorphin ameliorate mechanical hypersensitivity following nerve injury

scientific article published on 10 April 2010

Targeting of opioid-producing leukocytes for pain control

scientific article published on 20 July 2007

Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception

scientific article

Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of non-evoked ongoing pain

scientific article published on 24 June 2020

Why is morphine not the ultimate analgesic and what can be done to improve it?

scientific article published on September 2000

pKa of opioid ligands as a discriminating factor for side effects

scientific article published on 18 December 2019

μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice

scientific article

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