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List of works by Hongyuan Yang

A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza.

scientific article published on 23 February 2006

A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking

scientific article

A role for phosphatidic acid in the formation of "supersized" lipid droplets

scientific article

AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism

scientific article

ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore.

scientific article published on 23 April 2003

AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

scientific article published on 25 November 2021

Accumulation of squalene is associated with the clustering of lipid droplets

scientific article published on 22 October 2012

Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks.

scientific article

Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice

scientific article published on 24 February 2016

Adipose-specific knockout of SEIPIN/BSCL2 results in progressive lipodystrophy.

scientific article published on 12 March 2014

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1.

scientific article published on 17 August 2015

Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P/PI(3,4)P

scientific article published on 19 February 2019

An essential role of Hrs/Vps27 in endosomal cholesterol trafficking

scientific article published on 26 January 2012

Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice.

scientific article

Apoptosis and lipoapoptosis in the fission yeast Schizosaccharomyces pombe.

scientific article

Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population ⬇️

scientific article published on 08 June 2013

Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet

scientific article published on 04 February 2020

CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms

scientific article published on 23 September 2019

CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development.

scientific article published on 5 March 2016

CRISPR/Cas9-Mediated Generation of Niemann-Pick C1 Knockout Cell Line.

scientific article published on January 2017

Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast

scientific article published on 24 July 2008

Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells

scientific article published on 19 January 2011

Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay

scientific article

Cholesterol transport through lysosome-peroxisome membrane contacts

scientific journal article

Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiae

scientific article published on 23 October 2009

Controlling the size of lipid droplets: lipid and protein factors

scientific article published on 20 June 2012

Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells

scientific article published in November 2004

Cytochrome bc(1) regulates the mitochondrial permeability transition by two distinct pathways

scientific article published on 10 September 2004

DFCP1 associates with lipid droplets

scientific article published on 10 July 2019

Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: implications for cholesterol trafficking to the endoplasmic reticulum

scientific article published on 17 September 2008

Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators

scientific article

Endosomal cholesterol trafficking: protein factors at a glance.

scientific article

Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function

scientific article published on 14 November 2019

Extended synaptotagmins, peroxisome-endoplasmic reticulum contact and cholesterol transport

scientific article published on 11 June 2019

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

scientific article

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

scientific article published on 5 December 2011

Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2.

scientific article published on 24 April 2015

Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity

scientific article published on 01 February 1997

GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy

scientific article published on 01 February 2020

Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae

scientific article

Genome-wide screens for gene products regulating lipid droplet dynamics

scientific article published in January 2012

High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase.

scientific article

Human multidrug resistance associated protein 4 confers resistance to camptothecins.

scientific article published on November 2005

Identification of a 26S proteasome-associated UCH in fission yeast

scientific article published on 01 May 2000

Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis

article

Identification of two proteins, S14 and UIP1, that interact with UCH37

scientific article

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice

scientific article

Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs

scientific article

Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites

scientific article published on 08 November 2018

LDs comprise a hydrophobic, neutral lipid core

scientific article published on 01 January 2013

Lack of testicular seipin causes teratozoospermia syndrome in men.

scientific article

Lipid Raft-dependent Endocytosis of Close Homolog of Adhesion Molecule L1 (CHL1) Promotes Neuritogenesis ⬇️

scientific article published on November 9, 2012

Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids.

scientific article published on 28 June 2017

Mechanisms and regulation of cholesterol homeostasis

scientific article published on 17 December 2019

Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis ⬇️

scientific article published on September 26, 2011

Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents.

scientific article

Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport

scientific article published in December 2004

Nonvesicular sterol transport: two protein families and a sterol sensor?

scientific article published on 28 July 2006

Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites

scientific article published on 29 April 2015

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)

scientific article published on 20 December 2018

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

scientific article published on 2 October 2017

ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets

scientific article published on 01 January 2020

Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy

scientific article published on 10 January 2012

Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling.

scientific article published on 22 January 2018

Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway

scientific article published on 01 August 1996

Prediction of herb-drug metabolic interactions: a simulation study

scientific article published on 01 June 2005

Programmed cell death in fission yeast Schizosaccharomyces pombe.

scientific article published on 15 February 2008

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

scientific article

Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth

scientific article published on August 2014

Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends.

scientific article published on 13 February 2017

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

scientific article

Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase

scientific article published on 08 September 2003

Seipin ablation in mice results in severe generalized lipodystrophy

scientific article published on 6 May 2011

Seipin, adipogenesis and lipid droplets.

scientific article published on 15 April 2011

Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia

scientific article published on 01 January 2020

Structural basis for catalysis and substrate specificity of human ACAT1

scientific article published on 13 May 2020

Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins

scientific article

Sulphite oxidase gene expression in human brain and in other human and rat tissues

scientific article (publication date: 6 June 2003)

Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet

scientific article published on 28 November 2019

The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.

scientific article published on 14 October 2012

The biogenesis of lipid droplets: Lipids take center stage

scientific article published on 24 July 2019

The expression of SEIPIN in the mouse central nervous system

scientific article published on 30 November 2015

The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness

scientific article published on 26 January 2005

The redox regulation of intermediary metabolism by a superoxide-aconitase rheostat

scientific article

The role of oxysterol-binding protein and its related proteins in cancer

scientific article

The size and phospholipid composition of lipid droplets can influence their proteome

scientific article published on 25 October 2011

Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation

scientific article

Toward one step analysis of cellular lipidomes using liquid chromatography coupled with mass spectrometry: application to Saccharomyces cerevisiae and Schizosaccharomyces pombe lipidomics

scientific article published on 25 February 2010

Translocation efficiency, susceptibility to proteasomal degradation, and lipid responsiveness of apolipoprotein B are determined by the presence of beta sheet domains

scientific article published on 01 December 1998

Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice

scientific article

VPS13: A lipid transfer protein making contacts at multiple cellular locations

scientific article published on 4 September 2018

Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae.

scientific article

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