Search filters

List of works by Laura H Jacobson

A genetic upper limit to whole-body protein deposition in a strain of growing pigs

scientific article published in December 2006

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

scientific article

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

article

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system

scientific article

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

scientific article published on 15 December 2006

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

scientific article published on 9 January 2017

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

scientific article published on 25 September 2011

Correlation of cellular changes and spatial memory during aging in rats

scientific article published on 12 August 2008

Differential compartmentalization and distinct functions of GABAB receptor variants

scientific article

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine

scientific article

Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains

scientific article published on 25 January 2005

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).

scientific article published on 19 October 2015

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

scientific article published on 03 May 2018

Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

scientific article

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides

scientific article

Distinct effects of IPSU and suvorexant on mouse sleep architecture

scientific article published on 10 December 2013

Effect of feeding pasture-finished cattle different conserved forages on Escherichia coli in the rumen and faeces ⬇️

scientific article published on September 1, 2002

Electrical head-only stunning of fallow deer (Dama dama)

scientific article published on 01 February 1994

Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.

scientific article

Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents

scientific article

Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats

scientific article published in June 2010

Feeling strained? Influence of genetic background on depression-related behavior in mice: a review.

scientific article

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

scientific article published in August 2006

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

scientific article published on 21 September 2006

Heart rate as a measure of adaptation to stress in cattle

scientific article published on 01 December 1996

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia

scientific article published on 18 September 2013

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

scholarly article

Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors

scientific article published on 3 December 2013

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice

scientific article published on 17 May 2016

Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status

scientific article published on 04 March 2016

Orexin OX2 Receptor Antagonists as Sleep Aids

scientific article published on 2 December 2016

Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?

scientific article

Partitioning psychological and physical sources of transport-related stress in young cattle

scientific article published in March 1998

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.

scientific article published on 25 February 2016

Salivary cortisol as an indicator of stress in sheep (Ovis ovis)

scientific article published on 01 November 1995

Sex differences in mouse models of fear inhibition: Fear extinction, safety learning, and fear–safety discrimination

scientific article published on 15 April 2019

Specific roles of GABA(B(1)) receptor isoforms in cognition.

scientific article

Suvorexant for the treatment of insomnia

scientific article

The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease

scientific article published on 01 November 2018

The Gamma-Aminobutyric Acid B Receptor in Depression and Reward

scientific article published on 22 February 2018

The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.

scientific article published in June 2011

The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours

scholarly article by Ryan J Keenan published in November 2018

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity

scientific article published on 21 August 2007

Paulina is supported by:

About Paulina

Help