List of works - Lakshmi Wijeyewickrema

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

scientific article

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

scientific article

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

scientific article

Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS

scientific article

Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite Sarcoptes scabiei

scientific article published on 7 October 2009

Determination of the crystal structure and substrate specificity of ananain

scientific article published on 12 July 2019

Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate

scientific article

Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin

article

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

scientific article

Fractionation of snake venom metalloproteinases by metal ion affinity: A purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose

article

Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets

scientific article published on 01 April 2005

High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism

scientific article

Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.

scientific article published on August 2012

Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4.

scientific article

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?

scientific article published on 06 June 2011

Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.

scientific article

Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4.

scientific article

Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI

scientific article

Novel scabies mite serpins inhibit the three pathways of the human complement system

scientific article

Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions.

scientific article published in January 2004

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

scientific article published on 23 June 2016

Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display.

scientific article

Protease-associated import systems are widespread in Gram-negative bacteria

scientific article published on 15 October 2019

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

scientific article

Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites

scientific article published on 8 May 2017

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

scientific article published in February 2005

S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction

scientific article

Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway

scientific article

Serpins and the Complement System

article

Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI.

scientific article published in December 2007

Snake venom probes of platelet adhesion receptors and their ligands

scientific article

Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase

scientific article

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

scientific article

The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome

scientific article

The effects of exosite occupancy on the substrate specificity of thrombin

scientific article published on 26 July 2009

The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis

scientific article published on May 2009

The initiating proteases of the complement system: controlling the cleavage

scientific article published on 06 August 2007

The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition

scientific article published on January 2011

The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates

scientific article published on 07 August 2013

The role of the lys628 (192) residue of the complement protease, c1s, in interacting with Peptide and protein substrates

scientific article

The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.

scientific article published in September 2013

Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism.

scientific article published on 23 April 2013

Total synthesis of homogeneous variants of hirudin P6: a post-translationally modified anti-thrombotic leech-derived protein.

scientific article

List of works by Lakshmi Wijeyewickrema

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS

Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite Sarcoptes scabiei

Determination of the crystal structure and substrate specificity of ananain

Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate

Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

Fractionation of snake venom metalloproteinases by metal ion affinity: A purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose

Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets

High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism

Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.

Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4.

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?

Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.

Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4.

Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI

Novel scabies mite serpins inhibit the three pathways of the human complement system

Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions.

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display.

Protease-associated import systems are widespread in Gram-negative bacteria

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction

Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway

Serpins and the Complement System

Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI.

Snake venom probes of platelet adhesion receptors and their ligands

Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome

The effects of exosite occupancy on the substrate specificity of thrombin

The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis

The initiating proteases of the complement system: controlling the cleavage

The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition

The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates

The role of the lys628 (192) residue of the complement protease, c1s, in interacting with Peptide and protein substrates

The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.

Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism.

Total synthesis of homogeneous variants of hirudin P6: a post-translationally modified anti-thrombotic leech-derived protein.