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List of works by Patrick J. Hrdlicka

25 years and still going strong: 2'-O-(pyren-1-yl)methylribonucleotides - versatile building blocks for applications in molecular biology, diagnostics and materials science

scientific article published on 14 November 2017

2′-N-(Pyren-1-yl)acetyl-2′-Amino-α-L-LNA: Synthesis and Detection of Single Nucleotide Mismatches in DNA and RNA Targets

scientific article published on 01 July 2007

Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles

scientific article published on 28 August 2015

C2'-pyrene-functionalized triazole-linked DNA: universal DNA/RNA hybridization probes.

scientific article published on 16 November 2011

C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability

scientific article

C5-amino acid functionalized LNA: positively poised for antisense applications

scientific article published on August 2014

C5-functionalized DNA, LNA, and α-L-LNA: positional control of polarity-sensitive fluorophores leads to improved SNP-typing

scientific article published on 15 February 2011

C5-functionalized LNA: unparalleled hybridization properties and enzymatic stability

scientific article published on 01 November 2009

Carbohydrate-functionalized locked nucleic acids: oligonucleotides with extraordinary binding affinity, target specificity, and enzymatic stability.

scientific article published on 03 June 2014

Characterization of nerolidol biotransformation based on indirect on-line estimation of biomass concentration and physiological state in batch cultures of Aspergillus niger

scientific article published in January 2004

DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles.

scientific article published on 29 June 2012

DNA strands with alternating incorporations of LNA and 2'-O-(pyren-1-yl)methyluridine: SNP-discriminating RNA detection probes.

scientific article published on September 2013

Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection

scientific article published on 01 January 2007

Efficient Discrimination of Single Nucleotide Polymorphisms (SNPs) Using Oligonucleotides Modified with C5-Pyrene-Functionalized DNA and Flanking Locked Nucleic Acid (LNA) Monomers.

scientific article

Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAs

scientific article

Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

scientific article

Glowing locked nucleic acids: brightly fluorescent probes for detection of nucleic acids in cells.

scientific article

Gold-peptide nanoconjugate cellular uptake is modulated by serum proteins.

scientific article

Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

scientific article published on 25 September 2013

Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes

scientific article published on 10 June 2020

Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling

scientific article published on 29 September 2015

Invader LNA: efficient targeting of short double stranded DNA.

scientific article

Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications.

scientific article published in August 2015

Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides

scientific article published on 23 August 2013

Locked nucleic acid (LNA) induced effect on the hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers.

scientific article published on 09 June 2015

Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes

scientific article published on 21 March 2016

Mixed-Sequence Recognition of Double-Stranded DNA Using Enzymatically Stable Phosphorothioate Invader Probes

scientific article published on 29 July 2015

Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays

scientific article published in September 2005

N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.

scientific article published in January 2007

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

scientific article

Nicked Invader probes: multistranded and sequence-unrestricted recognition of double-stranded DNA

scientific article published in 2022

Novel insights into the use of Glowing LNA as nucleic acid detection probes--influence of labeling density and nucleobases

scientific article published on 9 November 2010

Nucleic acid structural engineering using pyrene-functionalized 2'-amino-alpha-L-LNA monomers and abasic sites

scientific article published on 19 August 2008

Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-beta-alanyl 2'-amino-LNA.

scientific article published on 3 February 2005

Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.

scientific article

Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.

scientific article

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids.

scientific article

Preparation of C5-functionalized locked nucleic acids (LNAs)

scientific article published on 01 March 2011

Pyrene-functionalized 2'-amino-alpha-L-LNA as potential diagnostic probes

scientific article published in January 2007

Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.

scientific article published on 13 April 2011

Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).

scientific article published on 4 June 2010

Recognition of Double-Stranded DNA Using Energetically Activated Duplexes Modified with N2'-Pyrene-, Perylene-, or Coronene-Functionalized 2'-N-Methyl-2'-amino-DNA Monomers.

scientific article

Recognition of double-stranded DNA using LNA-modified toehold Invader probes

scientific article published in 2021

Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers

scientific article

Recognition of mixed-sequence DNA duplexes: design guidelines for invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers.

scientific article

Recognition of mixed-sequence DNA targets using spermine-modified Invader probes

scientific article published on 01 October 2019

Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2'-triphenylene- and coronene-functionalized RNA monomers

scientific article published on 01 November 2017

SYNTHESIS OF A 2′-AMINO-α-L-LNA-T PHOSPHORAMIDITE

scientific article published on 01 January 2005

Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens

scientific article

Self-assembled monolayers of thiols adsorbed on Au/ZnO-functionalized silica nanosprings: photoelectron spectroscopy-analysis and detection of vaporized explosives

scientific article published on 05 August 2014

Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: lessons to be learned

scientific article published in December 2007

Synthesis and Hybridization Studies of 2‘-Amino-α-L-LNA and Tetracyclic “Locked LNA”†

scientific article published on 01 May 2006

Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd).

scientific article published on January 2005

Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).

scientific article published on February 2005

Synthesis and biophysical characterization of oligonucleotides modified with O2'-alkylated RNA monomers featuring substituted pyrene moieties

scientific article published on 01 January 2019

Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).

scientific article

Synthesis and biophysical studies of N2'-functionalized 2'-amino-alpha-L-LNA.

scientific article published in January 2007

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA

scientific article published on 11 December 2013

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-thio-2'-deoxy-2'-S-(pyren-1-yl)methyluridine

scientific article

Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2'-deoxyuridines.

scientific article

Synthesis, hybridization characteristics, and fluorescence properties of oligonucleotides modified with nucleobase-functionalized locked nucleic acid adenosine and cytidine monomers.

scientific article published on 24 June 2014

Synthesis, nucleic acid hybridization properties and molecular modelling studies of conformationally restricted 3′- O ,4′- C -methylene-linked α- l -ribonucleotides

scientific article published on 18 May 2006

Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.

scientific article

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