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List of works by Tuomo A Keinänen

A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells ⬇️

scientific article published on August 10, 2011

Activation of Polyamine Catabolism by N¹,N-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype

Alpha-methyl polyamines: efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase

scientific article published in January 2006

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.

scientific article published on August 2007

Aminooxy analogues of spermidine evidence the divergent roles of the charged amino nitrogens in the cellular physiology of spermidine

scientific article published on 01 January 1995

Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS.

scientific article published on 15 October 2013

Analysis of underivatized polyamines by reversed phase liquid chromatography with electrospray tandem mass spectrometry

scientific article published on 7 September 2007

Animal disease models generated by genetic engineering of polyamine metabolism.

scientific article

Charge Deficient Analogues of the Natural Polyamines ⬇️

scientific article published on January 1, 2014

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

scientific article published on 8 May 2012

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults

scientific article published on 25 June 2010

Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice

scientific article published on 3 December 2009

Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.

scientific article published on March 2005

Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.

scientific article

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A ⬇️

scientific article published on August 23, 2011

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

scientific article published on 27 February 2015

Methylated polyamines as research tools

scientific article published on 01 January 2011

Mice with targeted disruption of spermidine/spermine N-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

scientific article published in October 2006

Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase

scientific article published in January 2007

Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity.

scientific article

Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS

scientific article published on 05 August 2011

Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells.

scientific article

Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS.

scientific article published on 26 February 2008

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis

scientific article published on 27 September 2007

Selective regulation of polyamine metabolism with methylated polyamine analogues

scientific article published on 10 October 2013

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

scientific article

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A.

scientific article published on August 2013

Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts

scientific article published on 29 July 2009

Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase

scientific article published on 02 August 2011

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives

scientific article published on 13 December 2019

activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.

scientific article

alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage

scientific article published on 3 December 2009

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