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List of works by Hiroyuki Yasui

A cisplatin derivative that inhibits collagen fibril-formation in vitro

scientific article published on 5 November 2014

A new candidate for insulinomimetic vanadium complex: synergism of oxovanadium(IV)porphyrin and sodium ascorbate

scientific article published in March 2004

A new halogenated antidiabetic vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV): in vitro and in vivo insulinomimetic evaluations and metallokinetic analysis

scientific article published in February 2001

A novel drug delivery system for type 1 diabetes: insulin-mimetic vanadyl-poly(gamma-glutamic acid) complex.

scientific article published on 24 May 2006

A recirculatory model for local absorption and disposition of ciprofloxacin by measuring portal and systemic blood concentration difference

scientific article published in January 2002

A recirculatory model with enterohepatic circulation by measuring portal and systemic blood concentration difference

scientific article published in April 2003

Accumulation of Paprika Carotenoids in Human Plasma and Erythrocytes

scientific article published on 15 September 2015

Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes.

scientific article published on 23 October 2015

Age-dependent generation of reactive oxygen species in the skin of live hairless rats exposed to UVA light

scientific article published on 01 October 2003

Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes.

scientific article

Alternative continuous infusion method for analysis of enterohepatic circulation and biliary excretion of cefixime in the rat.

scientific article published in June 1994

An orally active antidiabetic vanadyl complex, bis(1-oxy-2-pyridinethiolato)oxovanadium(IV), with VO(S2O2) coordination mode; in vitro and in vivo evaluations in rats

scientific article published on 01 May 2000

Analysis of arterial-venous blood concentration difference of drugs based on recirculatory theory with fast inverse Laplace transform (FILT).

scientific article published in February 1991

Anti-Diabetic Effect of Organo-Chalcogen (Sulfur and Selenium) Zinc Complexes with Hydroxy-Pyrone Derivatives on Leptin-Deficient Type 2 Diabetes Model ob/ob Mice

scientific article

Anti-Oxidative Activity of Mytiloxanthin, a Metabolite of Fucoxanthin in Shellfish and Tunicates.

scientific article published on 11 May 2016

Anti-hyperglycemic Effect of Long-Term Bis(hinokitiolato)zinc Complex ([Zn(hkt)2]) Ingestion on Insulin Resistance and Pancreatic Islet Cells Protection in Type 2 Diabetic KK-Ay Mice.

scientific article published in January 2017

Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin.

scientific article published on 23 March 2010

Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin ⬇️

scientific article published on January 1, 2013

Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex.

scientific article published on September 2014

Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney

scientific article published in November 2017

Bis (aspirinato) zinc (II) complex successfully inhibits carotid arterial neointima formation after balloon-injury in rats

scientific article published on 01 December 2014

Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) activates Akt/protein kinase B independent of insulin signal transduction

scientific article

Challenge of studies on the development of new Zn complexes (Zn(opt)₂) to treat diabetes mellitus

scientific article published on 17 May 2011

Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

scientific article published on 24 October 2016

Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method

scientific article published in February 2007

Chemiluminescent detection and imaging of reactive oxygen species in live mouse skin exposed to UVA

scientific article published on 01 March 2000

Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis.

scientific article published on June 2016

Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelial carcinogenesis in rats.

scientific article published on 11 September 2013

Detoxification of 6-hydroxydopamine-induced Parkinsonian neurodegeneration by G-CYPMPO, a novel radical trapper

scientific article published on 17 February 2011

Development of PEGylated serum albumin with multiple reduced thiols as a long-circulating scavenger of reactive oxygen species for the treatment of fulminant hepatic failure in mice

scientific article published on 6 February 2014

Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

scientific article published on 7 February 2018

Development of a highly sensitive methodology for quantitative determination of fexofenadine in a microdose study by multiple injection method using ultra-high performance liquid chromatography with tandem mass spectrometry

scientific article published in January 2012

Development of a novel antidiabetic zinc complex with an organoselenium ligand at the lowest dosage in KK-A(y) mice.

scientific article published on 23 December 2012

Development of a novel high-throughput analytical methodology, multiple injection method, for quantitative analysis in drug metabolism and pharmacokinetic studies using liquid chromatography with tandem mass spectrometry

scientific article published in January 2011

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

scientific article (publication date: 6 December 2011)

Direct reaction between shikonin and thiols induces apoptosis in HL60 cells

scientific article

E10A, an adenovirus-carrying endostatin gene, dramatically increased the tumor drug concentration of metronomic chemotherapy with low-dose cisplatin in a xenograft mouse model for head and neck squamous-cell carcinoma.

scientific article

ESR characterization and metallokinetic analysis of Cr(V) in the blood of rats given carcinogen chromate(VI) compounds

scientific article published on 01 July 1999

Effect of HSP47 on prolyl 4-hydroxylation of collagen model peptides

scientific article published on 01 August 1999

Effect of a peroxynitrite scavenger, a manganese-porphyrin compound on airway remodeling in a murine asthma.

scientific article published on 25 February 2013

Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1-dependent p-nitrophenol hydroxylation in the liver microsomes of streptozotocin-induced type 1 diabetic rats

scientific article published in October 2005

Effect of temperature in perfusate on local hepatic disposition of BOF-4272, a new xanthine oxidase inhibitor

scientific article published in July 1995

Effects of Zn(II) complex with vitamins C and U, and carnitine on metabolic syndrome model rats

scientific article published on 24 June 2011

Effects of static magnetic field on dissolved oxygen levels in aqueous solutions containing copper(II), iron(II), and heme iron(III) complexes

scientific article published on 01 July 2000

Efficient reduction of Cys110 thiyl radical by glutathione in human myoglobin

scientific article published on 21 January 2011

Enteric-coating capsulation of insulinomimetic vanadyl sulfate enhances bioavailability of vanadyl species in rats

scientific article published on 01 May 2002

Essential role of singlet oxygen species in cytochrome P450-dependent substrate oxygenation by rat liver microsomes

scientific article

Evaluation of insulin-mimetic activities of vanadyl and zinc(II) complexes from the viewpoint of heterocyclic bidentate ligands

scientific article published on 24 December 2008

Evidence for singlet oxygen involvement in rat and human cytochrome P450-dependent substrate oxidations

scientific article published in January 2002

Feasibility of structural modification of retinoid X receptor agonists to separate blood glucose-lowering action from adverse effects: studies in KKA(y) type 2 diabetes model mice

scientific article published on 01 January 2012

Generation and distribution of reactive oxygen species in the skin of hairless mice under UVA: studies on in vivo chemiluminescent detection and tape stripping methods

scientific article published on 01 November 2006

HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone), an anti-lipid-peroxidative compound: its chemical and biochemical characterizations.

scientific article

Improved flow injection analysis (FIA) method for determining selenium in biological samples, and the effect of captopril administration on selenium levels and glutathione peroxidase activity in rat

scientific article published on 01 November 1993

Improvement of diabetic states in streptozotocin-induced type 1 diabetic rats by vanadyl sulfate in enteric-coated capsules

scientific article published in May 2005

In vitro study on the transport of zinc across intestinal epithelial cells using Caco-2 monolayers and isolated rat intestinal membranes

scientific article published on 01 January 2012

In vivo L-band ESR and quantitative pharmacokinetic analysis of stable spin probes in rats and mice

scientific article published on 01 July 1999

Inhibitory effect of CuSO₄ on α-glucosidase activity in ddY mice

scientific article published on 16 October 2009

Inhibitory effects of short-chain fatty acids on matrix metalloproteinase secretion from human colonic subepithelial myofibroblasts

scientific article published on 16 July 2008

Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers

scientific article

Investigating the target organs of novel anti-diabetic zinc complexes with organo‑selenium ligands

scientific article published on 12 May 2018

Investigation of Biodistribution and Speciation Changes of Orally Administered Dual Radiolabeled Complex, Bis(5-chloro-7-[131I]iodo-8-quinolinolato)[65Zn]zinc.

scientific article published in January 2017

Involvement of singlet oxygen in cytochrome P450-dependent substrate oxidations

scientific article published on 01 September 1999

Iron overload signature in chrysotile-induced malignant mesothelioma

scientific article

Isomeric effects of anti-diabetic α-lipoic acid with γ-cyclodextrin.

scientific article published on 2 July 2015

Local disposition of a new xanthine oxidase/xanthine dehydrogenase inhibitor, BOF-4272, in rat liver

scientific article published on 01 September 1994

Local pharmacokinetic analysis of a stable spin probe in mice by in vivo L-band ESR with surface-coil-type resonators

scientific article

Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.

scientific article published on 20 February 2013

Memory deficit in mice administered aluminum-maltolate complex

scientific article published in February 2006

Metallokinetic analysis of disposition of vanadyl complexes as insulin-mimetics in rats using BCM-ESR method

scientific article published on 01 February 2000

Metallokinetic study of zinc in the blood of normal rats given insulinomimetic zinc(II) complexes and improvement of diabetes mellitus in type 2 diabetic GK rats by their oral administration.

scientific article published in January 2002

Moment analysis of hepatic local disposition of allopurinol and oxipurinol: metabolism kinetics from allopurinol to oxipurinol in the rat isolated perfused liver

scientific article published on 01 June 1994

Moment analysis of stereoselective biliary excretion and chiral inversion of ketoprofen enantiomers in perfused rat liver

scientific article published on 01 November 1995

Moment analysis of stereoselective enterohepatic circulation and unidirectional chiral inversion of ketoprofen enantiomers in rat.

scientific article published in June 1996

Morphological analysis of the pancreas and liver in diabetic KK-A(y) mice treated with zinc and oxovanadium complexes

scientific article published on 01 September 2014

Multi-Omics Analysis to Generate Hypotheses for Mild Health Problems in Monkeys

scientific article published in 2021

Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats

scientific article

Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice.

scientific article

New hepatocellular diffusion model for analysis of hepatobiliary transport processes of drugs

scientific article published in April 1995

Novel screening method for ultraviolet protection: combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine

scientific article published on 01 December 2006

Oral administration of Bis(aspirinato)zinc(II) complex ameliorates hyperglycemia and metabolic syndrome-like disorders in spontaneously diabetic KK-A(y) mice: structure-activity relationship on zinc-salicylate complexes

scientific article published on 01 January 2011

Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway

scientific article published on 6 May 2016

Orally active antioxidative copper(II) aspirinate: synthesis, structure characterization, superoxide scavenging activity, and in vitro and in vivo antioxidative evaluations

scientific article (publication date: December 2005)

Orally administrated aluminum-maltolate complex enhances oxidative stress in the organs of mice

scientific article

Organ distribution of quantum dots after intraperitoneal administration, with special reference to area-specific distribution in the brain

scientific article

Pharmacokinetic analysis of ramatroban using a recirculatory model with enterohepatic circulation by measuring portal and systemic blood concentration difference in Sprague-Dawley and Eisai hyperbilirubinemic rats

scientific article

Pharmacokinetic study and trial for preparation of enteric-coated capsule containing insulinomimetic vanadyl compounds: implications for clinical use.

scientific article published on January 2004

Pharmacokinetic study on gastrointestinal absorption of insulinomimetic vanadyl complexes in rats by ESR spectroscopy

scientific article

Pharmacological and pharmacokinetic studies of anti-diabetic tropolonato-Zn(II) complexes with Zn(S(2)O(2)) coordination mode

scientific article published on 01 January 2012

Photocontrol of spatial orientation and DNA cleavage activity of copper(II)-bound dipeptides linked by an azobenzene derivative.

scientific article published on 14 May 2008

Potential of collagen-like triple helical peptides as drug carriers: Their in vivo distribution, metabolism, and excretion profiles in rodents

scientific article published on 01 November 2013

Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice.

scientific article published on 29 July 2009

RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.

scientific article

Reaction and Scavenging Mechanism of β-Carotene and Zeaxanthin with Reactive Oxygen Species

scientific article published on 8 December 2016

Reaction of Paprika Carotenoids, Capsanthin and Capsorubin, with Reactive Oxygen Species

scientific article published on 27 May 2016

Real-time chemiluminescent imaging and detection of reactive oxygen species generated in the UVB-exposed human skin equivalent model

scientific article published on 16 June 2006

Spinnokinetic analyses of blood disposition and biliary excretion of nitric oxide (NO)-Fe(II)-N-(dithiocarboxy)sarcosine complex in rats: BCM-ESR and BEM-ESR studies

scientific article published in October 2004

Structure-dependent metallokinetics of antidiabetic vanadyl-picolinate complexes in rats: studies on solution structure, insulinomimetic activity, and metallokinetics

scientific article

Superiority of zinc complex of acetylsalicylic acid to acetylsalicylic acid in preventing postischemic myocardial dysfunction.

scientific article published on 09 February 2015

Suppressive effect of caffeic acid and its derivatives on the generation of UVA-induced reactive oxygen species in the skin of hairless mice and pharmacokinetic analysis on organ distribution of caffeic acid in ddY mice

scientific article published on 01 November 2006

Suppressive effect of orally administered copper(II)-aspirinate (Cu2(asp)4) complex on the generation of reactive oxygen species in the skin of animals subjected to UVA exposure

scientific article (publication date: September 2007)

Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model

scientific article

Synthesis and in vitro insulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates

scientific article published on 18 March 2011

Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure

scientific article published on 20 January 2012

Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents

scientific article published on 4 June 2012

Synthetic study on selenocystine-containing peptides

scientific article published on 01 March 1993

Testicular Mineralization in KK-A(y) Mice Treated with an Oxovanadium Complex.

scientific article published on September 2013

The disposition and intestinal absorption of zinc in rats

scientific article

Topological stability and self-association of a completely hydrophobic model transmembrane helix in lipid bilayers

scientific article published in March 2002

Transient elevation of serum cystatin C concentrations during perioperative cisplatin-based chemotherapy in esophageal cancer patients.

scientific article published on 22 March 2012

Transport of Azithromycin into Extravascular Space in Rats

scientific article published on 6 September 2016

Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole

scientific article published on 31 October 2010

Unidirectional binding of clostridial collagenase to triple helical substrates.

scientific article published on 10 February 2009

Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model

scientific article published in April 2008

Visualization of biodistribution of Zn complex with antidiabetic activity using semiconductor Compton camera GREI

scientific article published on 8 December 2015

Zinc Complexes Developed as Metallopharmaceutics for Treating Diabetes Mellitus based on the Bio-Medicinal Inorganic Chemistry ⬇️

scientific article published on January 1, 2012

[Challenge of studies on the development of new Zn complexes to treat diabetes mellitus]

scientific article published on 01 January 2011

[Efforts to Promote Research Integrity in Academia]

scientific article published on 01 January 2018

[Improved spectrophotometric determination of total iron and iron(III) with o-hydroxyhydroquinonephthalein and their characterization]

scientific article published on 01 January 2011

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