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List of works by Chiara Zurzolo

4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy.

scientific article published on 15 February 2013

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

scientific article

A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance

scientific article

Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection

scientific article published on 01 May 2020

Analysis of detergent-resistant membranes associated with apical and basolateral GPI-anchored proteins in polarized epithelial cells

scientific article published on 20 September 2006

Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact

scientific article published on 09 February 2016

Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells

scientific article published in 2021

Caveolin transfection results in caveolae formation but not apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins in epithelial cells.

scientific article

Cell Biology of Prion Protein.

scientific article published on 29 July 2017

Cell Surface Biotinylation and Other Techniques for Determination of Surface Polarity of Epithelial Monolayers

Chapter 14 Mechanisms of Polarized Sorting of GPI-anchored Proteins in Epithelial Cells

Characterization of the Properties and Trafficking of an Anchorless Form of the Prion Protein

scientific article published in Journal of Biological Chemistry

Characterization of the role of dendritic cells in prion transfer to primary neurons

scientific article

Chiara Zurzolo: GPI knows the way to go.

scientific article published in March 2015

Clustering in the Golgi apparatus governs sorting and function of GPI-APs in polarized epithelial cells

scientific article published on 02 September 2019

Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?

scientific article

Coexpression of Wild-type and Mutant Prion Proteins Alters Their Cellular Localization and Partitioning into Detergent-resistant Membranes

scientific article published on 10 April 2008

Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells

scientific article published in Nature Communications

Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria

scientific article

Defined α-synuclein prion-like molecular assemblies spreading in cell culture

scientific article

Delivery of Na+,K(+)-ATPase in polarized epithelial cells

scientific article published on 01 April 1993

Detergent-resistant membrane domains but not the proteasome are involved in the misfolding of a PrP mutant retained in the endoplasmic reticulum

scientific article published on February 2006

Detergent-resistant membrane microdomains and apical sorting of GPI-anchored proteins in polarized epithelial cells

scientific article

Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin

scientific article

Development of antibody fragments for immunotherapy of prion diseases

scientific article published in March 2009

Different GPI-attachment signals affect the oligomerisation of GPI-anchored proteins and their apical sorting.

scientific article

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

scientific article published on 23 December 2016

Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells

scientific article published in April 2002

Distinct v-SNAREs regulate direct and indirect apical delivery in polarized epithelial cells

scientific article published on 01 September 2007

Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells

scientific article

Drosophila cells use nanotube-like structures to transfer dsRNA and RNAi machinery between cells

scientific article published on 03 June 2016

Effect of tolytoxin on tunneling nanotube formation and function

scientific article published on 05 April 2019

Evidence that tunnelling nanotube-like structures connect cells in mice

scientific article published on 12 August 2020

Exploring the role of lipids in intercellular conduits: breakthroughs in the pipeline

scientific article

Fate and propagation of endogenously formed Tau aggregates in neuronal cells

scientific article published on 12 November 2020

Fine intercellular connections in development: TNTs, cytonemes, or intercellular bridges?

scientific article published on 07 January 2020

Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling

scientific article published on January 2005

GPI-anchored proteins are confined in subdiffraction clusters at the apical surface of polarized epithelial cells

scientific article published on 18 October 2017

GPI-anchored proteins are directly targeted to the apical surface in fully polarized MDCK cells

scientific article

Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells

scientific article published on 25 November 2007

Glycosphingolipid clusters and the sorting of GPI-anchored proteins in epithelial cells

scientific article published on February 1, 1994

Glycosylphosphatidylinositol-anchored proteins are preferentially targeted to the basolateral surface in Fischer rat thyroid epithelial cells ⬇️

scientific article published on June 1, 1993

Glycosylphosphatidylinositol-anchored proteins: Membrane organization and transport

scientific article published on 16 December 2015

Golgi sorting regulates organization and activity of GPI proteins at apical membranes

scientific article

Human NPCs can degrade α-syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures

scientific article published on 05 September 2019

Identification and Characterization of Tunneling Nanotubes for Intercellular Trafficking

scientific article published on June 2015

Identification of an intracellular site of prion conversion

scientific article published on 08 May 2009

Lipid Rafts in Trafficking and Processing of Prion Protein and Amyloid Precursor Protein

Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells

scientific article

Lipids as targeting signals: lipid rafts and intracellular trafficking.

scientific article published on April 2004

Mechanisms of apical protein sorting in polarized thyroid epithelial cells

scientific article published on April 1999

Modulation of transcytotic and direct targeting pathways in a polarized thyroid cell line ⬇️

scientific article published on June 1, 1992

Morphological changes induced by prolonged TSH stimulation or starvation in the rat thyroid cell line FRTL.

scientific article

Multifaceted roles of tunneling nanotubes in intercellular communication.

scientific article published on 10 April 2012

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

scientific article published on 15 March 2013

Myo10 is a key regulator of TNT formation in neuronal cells.

scientific article published on 25 July 2013

N- and O-glycans are not directly involved in the oligomerization and apical sorting of GPI proteins

scientific article published on 6 September 2008

N-Glycosylation instead of cholesterol mediates oligomerization and apical sorting of GPI-APs in FRT cells

scientific article

New techniques lead to advances in epithelial cell polarity

scientific article published on December 1, 1991

Not on the menu: autophagy-independent clearance of prions

scientific article published on 19 July 2013

Oligomerization is a specific requirement for apical sorting of glycosyl-phosphatidylinositol-anchored proteins but not for non-raft-associated apical proteins

scientific article published on March 2007

Opposite polarity of virus budding and of viral envelope glycoprotein distribution in epithelial cells derived from different tissues ⬇️

scientific article published on May 1, 1992

Organization of GPI-anchored proteins at the cell surface and its physiopathological relevance

scientific article published on 24 July 2018

Patient-derived Glioblastoma Stem cells transfer mitochondria through Tunneling Nanotubes in Tumor Organoids

scientific article published on 27 November 2020

Permeabilization of MDCK cells with cholesterol binding agents: dependence on substratum and confluency

scientific article published on July 1994

Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells

scientific article published on 24 October 2005

Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules ⬇️

scientific article

Polarity signals in epithelial cells.

scientific article

Polarized secretion of plasminogen activators by epithelial cell monolayers

scientific article published on December 1992

PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation

scientific article published on 30 June 2004

PrPC Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK Cells

scientific article

PrPC is sorted to the basolateral membrane of epithelial cells independently of its association with rafts

scientific article published on November 2002

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

scientific article published on January 2015

Prions hijack tunnelling nanotubes for intercellular spread

scientific article

Prions: protein only or something more? Overview of potential prion cofactors

scientific article published on January 2006

Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins

scientific article

Rab11a-Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling

scientific article published on 05 October 2018

Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells

scientific article published on 08 October 2020

Regulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo

scientific article

Selective roles for cholesterol and actin in compartmentalization of different proteins in the Golgi and plasma membrane of polarized cells

scientific article published on 12 August 2008

Sensitivity of polarized epithelial cells to the pore-forming toxin aerolysin.

scientific article

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

scientific article published on 27 November 2012

Sorting of GPI-anchored proteins from yeast to mammals--common pathways at different sites?

scientific article

Synergistic inactivation of AXL: a (cross)road to cure ovarian cancer?

scientific article published on 02 July 2018

Synthesis of extracellular matrix glycoproteins by a differentiated thyroid epithelial cell line ⬇️

scientific article published on 01 April 1988

The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein.

scientific article published on 13 April 2016

The Priority position paper: Protecting Europe's food chain from prions

scientific article

The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes

scientific journal article

The Ways of Actin: Why Tunneling Nanotubes Are Unique Cell Protrusions

scientific article published on 09 December 2020

The Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes

scientific article published on 18 October 2019

The best of both worlds- bringing together cell biology and infection at the Institut Pasteur

scientific article published on 01 June 2019

The best of both worlds-bringing together cell biology and infection at the Institut Pasteur

scientific article published on 25 April 2019

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

scientific article published on May 2013

The fate of PrP GPI-anchor signal peptide is modulated by P238S pathogenic mutation.

scientific article

The highways and byways of prion protein trafficking

scientific article

The neuroendocrine protein VGF is sorted into dense-core granules and is secreted apically by polarized rat thyroid epithelial cells

scientific article published in April 2004

The order of rafts. Conference on microdomains, lipid rafts and caveolae

scientific article published on 21 November 2003

The polarized epithelial phenotype is dominant in hybrids between polarized and unpolarized rat thyroid cell lines ⬇️

scientific article published on January 1, 1991

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease

scientific article published on 25 January 2019

The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.

scientific article

Trafficking and Membrane Organization of GPI-Anchored Proteins in Health and Diseases

scientific article published on 15 April 2015

Trafficking and degradation pathways in pathogenic conversion of prions and prion-like proteins in neurodegenerative diseases

scientific article

Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine

scientific article

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes

scientific article published on 18 June 2013

Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

scientific article published on 17 October 2017

Tunneling Nanotubes: The Fuel of Tumor Progression?

scientific article published on 26 May 2020

Tunneling nanotubes and tumor microtubes—Emerging data on their roles in intercellular communication and pathophysiology: Summary of an International FASEB Catalyst Conference October 2023

scientific article published on 11 March 2024

Tunneling nanotubes provide a novel route for SARS-CoV-2 spreading between permissive cells and to non-permissive neuronal cells

scientific article

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes

scientific article published on 22 August 2016

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases.

scientific article published on 7 October 2016

Tunnelling nanotubes: a highway for prion spreading?

scientific article published on April 2009

VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells.

scientific article published on January 1994

Wiring through tunneling nanotubes--from electrical signals to organelle transfer

scientific article published on 07 March 2012

alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption

scientific journal article

α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

scientific article published on 20 July 2021

α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading

scientific article published on 19 July 2017

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