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List of works by Michael J. Quon

A Method of Delivering Dialysate of Constantly Decreasing Osmolality During Dialysis ⬇️

scientific article published on 01 November 1979

A mathematical model and computer simulation study of insulin receptor regulation

scientific article published in May 1991

A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

scientific article published on April 2003

A phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells

scientific article published on 01 January 1999

ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development

scientific article

Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle

scientific article published on 14 October 2016

Additive beneficial cardiovascular and metabolic effects of combination therapy with ramipril and candesartan in hypertensive patients

scientific article published on 05 May 2007

Additive beneficial effects of atorvastatin combined with amlodipine in patients with mild-to-moderate hypertension

scientific article published on 3 August 2009

Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia

scientific article published in May 2005

Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients

scientific article published on 29 November 2004

Adiponectin and cardiovascular disease: response to therapeutic interventions.

scientific article published on 19 January 2007

Adiponectin stimulates production of nitric oxide in vascular endothelial cells.

scientific article published on 27 August 2003

Amyloid beta oligomers induce impairment of neuronal insulin receptors

scientific article published on 24 August 2007

Anti-inflammatory and metabolic effects of candesartan in hypertensive patients.

scientific article

Are statins effective for simultaneously treating dyslipidemias and hypertension?

scientific article published on 26 July 2007

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

scientific article (publication date: 4 July 2003)

Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model

scientific article published in July 2005

Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia

scientific article published in June 2005

Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor-alpha activators.

scientific article

C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1.

scientific article published on 07 May 2009

Caveats to aggressive lowering of lipids by specific statins

scientific article

Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy

scientific article published on 26 February 2015

Characterization of a mutant GLUT4 lacking the N-glycosylation site: studies in transfected rat adipose cells.

scientific article

Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.

scientific article

Combined therapy with ramipril and simvastatin has beneficial additive effects on tissue factor activity and prothrombin fragment 1+2 in patients with type 2 diabetes

scientific article published on 11 September 2006

Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice

scientific article published on 14 November 2007

Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats.

scientific article published on 25 August 2009

Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance.

scientific article published on 16 May 2008

Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage

scientific article

Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.

scientific article published on 22 December 2005

Deterioration of glucose homeostasis in type 2 diabetic patients one year after beginning of statins therapy

scientific article published on 8 May 2012

Differential metabolic effects of distinct statins.

scientific article

Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients.

scientific article published on 27 September 2008

Differential metabolic effects of rosuvastatin and pravastatin in hypercholesterolemic patients.

scientific article published on 26 December 2011

Distinct mechanisms for globular adiponectin that integrate vascular and metabolic actions of insulin to help maintain coordinated cardiovascular and glucose homeostasis.

scientific article published in April 2013

Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy.

scientific article

Dynamic changes in plasma proinsulin/insulin ratio during insulin secretion influence correlation between radioimmunoassay (RIA) and IMX measurements of insulin

scientific article published in June 1999

EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR.

scientific article published on 16 January 2007

Effects of fenofibrate therapy on circulating adipocytokines in patients with primary hypertriglyceridemia

scientific article published on 29 October 2010

Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells

scientific article published on 01 September 1996

Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells ⬇️

scientific article published on November 30, 1997

Effects of simvastatin therapy on circulating adipocytokines in patients with hypercholesterolemia

scientific article published on 20 November 2010

Efonidipine simultaneously improves blood pressure, endothelial function, and metabolic parameters in nondiabetic patients with hypertension

scientific article published on 10 March 2007

Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.

scientific article published on 15 March 2007

Escherichia coli K1 internalization via caveolae requires caveolin-1 and protein kinase Calpha interaction in human brain microvascular endothelial cells

scientific article

Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.

scientific article published on September 2005

Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring

scientific article published on 20 May 2016

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.

scientific article

Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes.

scientific article

Extracellular conversion of adiponectin hexamers into trimers

scientific journal article

FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity.

scientific article

G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis

scientific article

Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells

scientific article published on 14 November 2006

Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter.

scientific article published on December 2000

Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1

scientific article

High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases

scientific article

High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance

scientific article published on 26 August 2005

Impaired insulin secretion in the Turner metabolic syndrome

scientific article published in July 2004

Infliximab therapy restores adiponectin expression in perivascular adipose tissue and improves endothelial nitric oxide-mediated vasodilation in mice with type 1 diabetes.

scientific article published on 23 August 2016

Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells

scientific article published on 13 November 2001

Insulin action and insulin resistance in vascular endothelium.

scientific article published on July 2007

Insulin and the insulin receptor in experimental models of learning and memory.

scientific article published on April 2004

Insulin receptor binding kinetics: modeling and simulation studies

scientific article published in August 2000

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

scientific article published on 30 April 2009

Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells.

scientific article published on November 1997

Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production.

scientific article published on 25 March 2005

Insulin signal transduction pathways

scientific article published in November 1994

Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

scientific article published on 11 June 2001

Leptin and cardiovascular disease: response to therapeutic interventions

scientific article published on June 2008

Letter by Koh and Quon regarding article, "Evidence mandating earlier and more aggressive treatment of hypercholesterolemia".

scientific article

Letter re: Limited accuracy of surrogates of insulin resistance during puberty in obese and lean children at risk for altered glucoregulation

scientific article published in July 2005

Limitations of the fasting glucose to insulin ratio as an index of insulin sensitivity

scientific article

MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness.

scientific article published on 28 February 2006

Man shall not live by bread alone.

scientific article published on 24 October 2014

Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications

scientific article

Modulation of adiponectin as a potential therapeutic strategy

scientific article

Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop

scientific article published on 14 August 2003

Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.

scientific article published on 13 November 2003

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

scientific article

Obesity modifies the effects of the Asp905Tyr variant of PPP1R3A on risk of type 2 diabetes and insulin sensitivity

scientific article published on 01 September 2007

Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects

scientific article

Overexpression of protein tyrosine phosphatase-alpha (PTP-alpha) but not PTP-kappa inhibits translocation of GLUT4 in rat adipose cells

scientific article published on 01 February 1999

PAX3/forkhead homolog in rhabdomyosarcoma oncoprotein activates glucose transporter 4 gene expression in vivo and in vitro.

scientific article published on November 2002

PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes

scientific article (publication date: February 2002)

PTEN does not modulate GLUT4 translocation in rat adipose cells under physiological conditions

scientific article published on November 2001

Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect

scientific article published on 29 May 2003

Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor

scientific article

Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute [...]

scientific article

Potentially important considerations in choosing specific statin treatments to reduce overall morbidity and mortality.

scientific article

Predicted effects of hemoglobin A1c assay precision on a patient population distribution of serial hemoglobin A1c difference values.

scientific article published on 06 December 2006

Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.

scientific article

Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes

scientific article published on 01 October 1999

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

scientific article

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.

scientific article published on 17 January 2008

Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

scientific article published on 01 March 1997

QUICKI is a useful and accurate index of insulin sensitivity

scientific article published in February 2002

Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.

scientific article published in July 2000

Reciprocal relationships between abnormal metabolic parameters and endothelial dysfunction.

scientific article published on February 2007

Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.

scientific article

Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor

scientific article published on 01 March 1998

Repeatability characteristics of simple indices of insulin resistance: implications for research applications

scientific article published in November 2001

Response to comment on Sarkar et al. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes care 2014;37:666-670.

scientific article published on October 2014

Role of lipotoxicity in endothelial dysfunction

scientific article

Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3.

scientific article published on 8 May 2003

Role of renin-angiotensin system blockades in reciprocal relationship between insulin resistance and endothelial dysfunction

scientific article published on 08 November 2010

S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

scientific article

Secretion of Annexin II via activation of insulin receptor and insulin-like growth factor receptor.

scientific article published on 12 November 2002

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

scientific article published on 25 September 2002

Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia.

scientific article published on 19 November 2011

Simple modeling allows prediction of steady-state glucose disposal rate from early data in hyperinsulinemic glucose clamps.

scientific article

Simvastatin improves flow-mediated dilation but reduces adiponectin levels and insulin sensitivity in hypercholesterolemic patients

scientific article

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway.

scientific article

Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.

scientific article published on March 2002

The effects of simvastatin, losartan, and combined therapy on soluble CD40 ligand in hypercholesterolemic, hypertensive patients

scientific article published on 28 February 2006

The union of vascular and metabolic actions of insulin in sickness and in health

scientific article

Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin

scientific article published on 26 March 2013

Transfection of DNA into isolated rat adipose cells by electroporation: evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture

scientific article published in July 1993

Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance

scientific article published in December 2006

Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462.

scientific article published in February 1995

Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells

scientific article published in July 2001

Vascular and metabolic effects of combined therapy with ramipril and simvastatin in patients with type 2 diabetes

scientific article published on 9 May 2005

Vascular and metabolic effects of treatment of combined hyperlipidemia: focus on statins and fibrates.

scientific article published on 20 July 2007

Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus.

scientific article published in March 2007

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