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List of works by Quan Chen

3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of α-synuclein in PC12 cells

scientific article published on 21 February 2015

A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells.

scientific article published on 7 August 2015

A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis

scientific article published on 31 May 2013

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

scientific article published on 27 December 2018

A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.

scientific article published on 17 April 2014

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

scientific journal article

A study on permeability transition pore opening and cytochrome c release from mitochondria, induced by caspase-3 in vitro

scientific article published in January 2002

A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia

scientific article

ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance.

scientific article published on 11 August 2016

Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma

scientific article

Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration

scientific article

Arsenic induces caspase- and mitochondria-mediated apoptosis inSaccharomyces cerevisiae

scholarly article by Li Du et al published September 2007 in FEMS Yeast Research

Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells

scientific article published in May 2005

Autophagy researchers

scientific article published on 20 September 2013

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

scientific article published on May 2010

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

scientific article published on 01 November 2008

CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer.

scientific article published on 15 February 2013

Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release

scientific article

Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells

scientific article

Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes

scientific article

Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis

scientific article published on 15 March 2008

Cytotoxic activities of new jadomycin derivatives.

scientific article published on June 2005

Disruption of Smad5 gene induces mitochondria-dependent apoptosis in cardiomyocytes

scientific article published on 17 March 2005

Drp1 is dispensable for mitochondria biogenesis in induction to pluripotency but required for differentiation of embryonic stem cells.

scientific article

Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy

scientific article published on 26 April 2016

Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide

scientific article

Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs

scientific article published on June 2013

G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion

scientific article published on 19 October 2010

Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2

article by Xiaobo Lei et al published October 2006 in FASEB Journal

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Human Bop is a novel BH3-only member of the Bcl-2 protein family

scientific article

Hypoxia activation of mitophagy and its role in disease pathogenesis.

scientific article published on 10 February 2015

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

scientific article

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

scientific article published on 20 December 2016

Identification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis

scientific article

Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins

scientific article (publication date: 13 June 2003)

Investigation into the regulation mechanisms of TRAIL apoptosis pathway by mathematical modeling

scientific article published in February 2010

Involvement of death receptor signaling in mechanical stretch-induced cardiomyocyte apoptosis

article by Xudong Liao et al published May 2005 in Life Sciences

Mechanical stretch induces mitochondria-dependent apoptosis in neonatal rat cardiomyocytes and G2/M accumulation in cardiac fibroblasts

scientific journal article

Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration

scientific journal article

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy

scientific article published on 19 January 2017

Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

scientific article published on 27 May 2015

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

scientific article

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

scientific article published on April 2016

Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury

scientific article published on 21 March 2017

Molecular signaling toward mitophagy and its physiological significance.

scientific article published on 18 April 2013

Monitoring Mitophagy in Mammalian Cells

scientific article published on 9 December 2016

Monitoring Mitophagy in Mammalian Cells

scientific article published on 01 January 2014

Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus

scientific journal article

Multi-Patterned Dynamics of Mitochondrial Fission and Fusion in a Living Cell ⬇️

scientific article (publication date: 2012)

Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.

scientific article published on 7 November 2011

Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes

scientific article published on 28 July 2006

Nix-mediated mitophagy regulates platelet activation and life span

scientific article published on 01 August 2019

One-step on-column affinity refolding purification and functional analysis of recombinant human VDAC1

article

Osteopontin, a possible modulator of cancer stem cells and their malignant niche.

scientific article published on May 2013

Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.

scientific article published on 7 March 2013

Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease

scientific article (publication date: February 2016)

Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule-dependent mechanism

scientific article

Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease

scientific article

Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim.

scientific article

Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells

scientific article

RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1.

scientific article

Receptor-mediated mitophagy in yeast and mammalian systems

scientific article

Reciprocal interactions between tumor-associated macrophages and CD44-positive cancer cells via osteopontin/CD44 promote tumorigenicity in colorectal cancer

scientific article published on 18 December 2012

Redox Regulation of Apoptosis before and after Cytochrome C Release.

scientific article

Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death

scientific article published on April 2008

Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

scientific article published on 09 December 2016

Role of Apo2L/TRAIL and Bcl-2-family proteins in apoptosis of multiple myeloma.

scientific article

Role of Ca2+ signaling in initiation of stretch-induced apoptosis in neonatal heart cells.

scientific article published in October 2003

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.

scientific article published on April 2015

Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells

scientific article published on 5 February 2009

Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells

scientific article published on 18 March 2014

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy.

scientific article published on 21 September 2016

Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis

scientific article

Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide/galactosamine-induced acute liver injury.

scientific article published in October 2009

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy

scientific article

The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells

scientific article

The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation

scientific article published on May 2005

Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

scientific article published on 31 March 2016

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