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List of works by Lucy Walker

1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.

scientific article

A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells

scientific article published on 28 January 2015

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.

scientific article

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

scientific article

Activation of human T cells with superantigen (staphylococcal enterotoxin B) and CD28 confers resistance to apoptosis via CD95

scientific article published on 01 March 1998

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

scientific article

B cell depletion in autoimmune diabetes: insights from murine models.

scientific article published on 03 March 2011

B1 cells promote pancreas infiltration by autoreactive T cells.

scientific article

CD28 costimulation: Walking the immunological tightrope ⬇️

scientific article published on January 1, 2013

CD4 + CD25 + Cells Controlling a Pathogenic CD4 Response Inhibit Cytokine Differentiation, CXCR-3 Expression, and Tissue Invasion

scientific article published on 01 September 2004

CD4 T cell differentiation in type 1 diabetes.

scientific article published on 23 June 2015

CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells

scientific article published in May 2003

CD4+ CD25+ Treg: divide and rule?

scientific article published on February 2004

CTLA-4 and Autoimmunity: New Twists in the Tale

scientific article

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

scientific article

CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen

scientific article published in December 2002

CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells

scientific article published on 01 May 2019

CTLA4 gene polymorphism and autoimmunity

scientific article

Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

scientific article published on October 1999

Confusing signals: recent progress in CTLA-4 biology

scientific article published on 09 January 2015

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

scientific article published on 01 January 2009

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells

scientific article published on 01 November 2006

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

scientific article published on 17 February 2010

Down-regulation of CD28 via Fas (CD95): influence of CD28 on T-cell apoptosis

scientific article

Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10

scientific article (publication date: July 2006)

Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4.

scientific article published in January 2003

Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

scientific article published on 03 August 2020

Follicular helper T cell signature in type 1 diabetes

scientific article

Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen

scientific article published on 03 October 2006

Functional tolerance is maintained despite proliferation of CD4 T cells after encounter with tissue-derived antigen

scientific article published in September 2002

Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs

scientific article

Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease

scientific article published on 20 April 2015

IL-2-independent activation and proliferation in human T cells induced by CD28.

scientific article

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.

scientific article published on 22 March 2012

IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells

scientific article published on 27 January 2014

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.

scientific article

Immune regulation and colitis: suppression of acute inflammation allows the development of chronic inflammatory bowel disease

scientific article

Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

scientific article published on 01 November 2011

Lack of activation induced cell death in human T blasts despite CD95L up-regulation: protection from apoptosis by MEK signalling

scientific article published on 01 December 1999

MAIT cells in type 1 diabetes: a good friend turned bad.

scientific article

Maintaining a Competitive Edge: New Rules for Peripheral T Cell Homeostasis

scientific article published on 01 October 2012

Natural Treg in autoimmune diabetes: all present and correct?

scientific article published on 01 November 2008

PD-1 and CTLA4: Two checkpoints, one pathway?

scientific article published on May 2017

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.

scientific article published on 16 March 2018

Positive and negative regulation of human T cell activation mediated by the CTLA-4/CD28 ligand CD80

scientific article published on 01 October 1998

Publisher Correction: Targeting co-stimulatory molecules in autoimmune disease

scientific article published on 18 November 2020

Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential.

scientific article

Regulatory T cells overturned: the effectors fight back

scientific article published on April 2009

Regulatory T cells: Folate receptor 4: a new handle on regulation and memory?

scientific article published on 21 August 2007

Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.

scientific article published in April 2008

Targeting co-stimulatory molecules in autoimmune disease

scientific article published on 16 September 2020

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses ⬇️

scientific article published on November 25, 2011

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology

scientific article published on August 2006

Treg and CTLA-4: Two intertwining pathways to immune tolerance ⬇️

scientific article published on July 10, 2013

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