List of works - David Drewry

2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor

scientific article published in July 2001

A Chemical Probe Targeting AAK1 and BMP2K

A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation

scientific article published on 20 November 2020

A public-private partnership to unlock the untargeted kinome

scientific article published in January 2013

A rapid three-component MgI(2)-mediated synthesis of 3,3-pyrollidinyl spirooxindoles

scientific article

An in silico screen and structural analysis identifies bacterial kinase inhibitors which act with β-lactams to inhibit mycobacterial growth

scientific article published on 18 October 2018

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

scientific article published on 05 May 2006

Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

scientific article published in December 2008

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

scientific article published on 11 November 2019

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model

scientific article published on 01 April 2020

CDK16: the pick of the understudied PCTAIRE kinases

scientific article published on 01 July 2019

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

scientific article published on 04 June 2019

Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

scientific article published on 02 October 2019

Comprehensive Survey of CDK Inhibitor Selectivity in Live Cells with Energy Transfer Probes

scientific article published on 23 December 2019

Comprehensive characterization of the Published Kinase Inhibitor Set

scientific article

Concise, Gram-Scale Synthesis of Furo[2,3-B]pyridines, with Functional Handles for Chemoselective Cross-Coupling

scholarly article published 17 March 2020

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

scientific article published on 25 September 2018

Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3

scientific article published on 26 October 2020

Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma

scientific article published on 19 April 2019

Development and Comparison of Complementary Methods to Study Potential Skin and Inhalational Exposure to Pathogens During Personal Protective Equipment Doffing

scientific article published on 01 September 2019

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

scientific article published on 23 March 2015

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

scientific article

Discovery of thiophene inhibitors of polo-like kinase

scientific article

EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen

scientific article

Effect of an Intervention Package and Teamwork Training to Prevent Healthcare Personnel Self-contamination During Personal Protective Equipment Doffing

scientific article published on 01 September 2019

Enhancements of screening collections to address areas of unmet medical need: an industry perspective

scientific article

High-throughput manual parallel synthesis using SynPhase crowns and lanterns.

scientific article

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

scientific article published on 13 January 2020

In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases

scientific article published on 08 December 2017

Kinase-targeted library design through the application of the PharmPrint methodology

scientific article

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.

scientific article

New tools for carbohydrate sulfation analysis: heparan sulfate 2--sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

article

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

article

PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

scientific article published on 28 September 2020

Plasmodium kinases as targets for new-generation antimalarials

scientific article published on December 2012

Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays

scientific article

Progress towards a public chemogenomic set for protein kinases and a call for contributions

scientific article

Quantifying CDK inhibitor selectivity in live cells

scientific article published on 02 June 2020

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.

scientific article published on 09 June 2015

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

scientific article published on 26 February 2019

Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)

scientific article

Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni

scientific article

List of works by David Drewry

2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor

A Chemical Probe Targeting AAK1 and BMP2K

A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation

A public-private partnership to unlock the untargeted kinome

A rapid three-component MgI(2)-mediated synthesis of 3,3-pyrollidinyl spirooxindoles

An in silico screen and structural analysis identifies bacterial kinase inhibitors which act with β-lactams to inhibit mycobacterial growth

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model

CDK16: the pick of the understudied PCTAIRE kinases

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

Comprehensive Survey of CDK Inhibitor Selectivity in Live Cells with Energy Transfer Probes

Comprehensive characterization of the Published Kinase Inhibitor Set

Concise, Gram-Scale Synthesis of Furo[2,3-B]pyridines, with Functional Handles for Chemoselective Cross-Coupling

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3

Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma

Development and Comparison of Complementary Methods to Study Potential Skin and Inhalational Exposure to Pathogens During Personal Protective Equipment Doffing

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Discovery of thiophene inhibitors of polo-like kinase

EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen

Effect of an Intervention Package and Teamwork Training to Prevent Healthcare Personnel Self-contamination During Personal Protective Equipment Doffing

Enhancements of screening collections to address areas of unmet medical need: an industry perspective

High-throughput manual parallel synthesis using SynPhase crowns and lanterns.

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases

Kinase-targeted library design through the application of the PharmPrint methodology

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.

New tools for carbohydrate sulfation analysis: heparan sulfate 2--sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

Plasmodium kinases as targets for new-generation antimalarials

Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays

Progress towards a public chemogenomic set for protein kinases and a call for contributions

Quantifying CDK inhibitor selectivity in live cells

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)

Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni