List of works - Panagiotis Procopiou

2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis.

scientific article published on 27 February 2016

2-Iodoisatogens: versatile intermediates for the synthesis of nitrogen heterocycles

scientific article published on 23 December 2014

4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists

scientific article published on 6 December 2007

A metathesis-based approach to the synthesis of 2-pyridones and pyridines

scientific article published on 23 December 2007

A metathesis-based approach to the synthesis of furans

scientific article published on 23 February 2007

A mild and regioselective route to functionalized quinazolines.

scientific article

Beta-diketiminato calcium and magnesium amides; model complexes for hydroamination catalysis

scientific article

Bis(diphenylphosphido) derivatives of the heavier group 2 elements

scientific article published on 3 November 2007

Bis(trimethylsilyl)methyl derivatives of calcium, strontium and barium: potentially useful dialkyls of the heavy alkaline earth elements

scientific article published in January 2008

Carbodiimide insertion reactions of homoleptic heavier alkaline earth amides and phosphides

scientific article published on 7 July 2010

Catalytic 2,3,4-hexatriene formation by terminal alkyne coupling at calcium

scientific article published on 27 March 2009

Cation Charge Density and Precatalyst Selection in Group 2-Catalyzed Aminoalkene Hydroamination

scientific article (publication date: 28 March 2011)

Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis.

scientific article published on 21 April 2017

Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosi

scientific article published on 14 September 2018

Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing

scientific article published on 20 December 2013

Heavier Alkaline Earth Amides as Catalysts for the Tischenko Reaction

scientific article published on 01 January 2007

Heavier Group 2 Metals and Intermolecular Hydroamination: A Computational and Synthetic Assessment

scientific article published on 01 September 2009

Heavier alkaline earth catalysts for the intermolecular hydroamination of vinylarenes, dienes, and alkynes

scientific article published on 18 January 2012

Heavier alkaline earth catalyzed ene-yne cyclizations: atom-efficient access to tetrahydroisoquinoline frameworks

scientific article published on 10 November 2014

Heavier group 2 element-catalysed hydroamination of isocyanates

scientific article published on 12 September 2008

Helical structure of tercyclopropanedimethanol in solution

scientific article published on 01 March 2006

Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists

scientific article

Imino Sulfinamidines: Synthesis and Coordination Chemistry of a Novel Class of Chiral Bidentate Ligands

scientific article published on 01 April 2006

Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.

scientific article published on November 1993

Insertion reactions of beta-diketiminate-stabilised calcium amides with 1,3-dialkylcarbodiimides.

scientific article

Intramolecular hydroamination of aminoalkenes by calcium and magnesium complexes: a synthetic and mechanistic study.

scientific article published in July 2009

Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists

scientific article

Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists

scientific article

Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation

scientific article published on 07 March 2012

Modular isoquinoline synthesis using catalytic enolate arylation and in situ functionalization

scientific article published on 19 November 2013

Novel glucocorticoid antedrugs possessing a 17beta-(gamma-lactone) ring.

scientific article

Oxazole synthesis with minimal purification: synthesis and application of a ROMPgel Tosmic reagent.

scientific article

Oxazoline-Promoted Rh-Catalyzed C-H Amidation of Benzene Derivatives with Sulfonamides and Trifluoroacetamide. A Comparative Study

scientific article published on 07 November 2016

Palladium-catalyzed enolate arylation as a key C-C bond-forming reaction for the synthesis of isoquinolines

scientific article published on 03 December 2015

Potassium trimethylsilanolate induced cleavage of 1,3-oxazolidin-2- and 5-ones, and application to the synthesis of (R)-salmeterol

scientific article published in April 2003

Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Syn

scientific article published on 05 August 2019

Rearrangement of a 16alpha,17alpha-Epoxy-16beta-methylandrostane-17beta-carbothioic Acid to a 17beta-Mercapto-16beta-methylandrostane-17alpha,16alpha-carbolactone

scientific article published on 01 October 1998

Reversibility in the protonolysis of a beta-diketiminate stabilised calcium bis(trimethylsilyl)amide with benzylamine

scientific article

Ring-closing metathesis: novel routes to aromatic heterocycles

scientific article published on 01 January 2008

Ritter-type reactions of N-chlorosaccharin: a method for the electrophilic diamination of alkenes

scientific article published on 01 September 2003

Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism

scientific article

Short and efficient syntheses of protoberberine alkaloids using palladium-catalyzed enolate arylation

scientific article published on 27 October 2014

Solid-phase synthesis of isoxazoles using vinyl ethers as chameleon catches

scientific article published on 01 October 2001

Studies on the stereochemical assignment of 3-acylidene 2-oxindoles.

scientific article published on 11 April 2014

Synthesis and characterization of coronanes: multicyclopropane-fused macrocyclic arrays

scientific article

Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis

scientific article published on 26 May 2016

Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists

scientific article published on 31 August 2012

Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.

scientific article

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups

scientific article published in April 2009

Synthesis of (R)-alpha-benzylmethionine: a novel rearrangement during alkylation of the Seebach (R)-methionine oxazolidinone

scientific article published in August 2003

Synthesis of C-19-functionalized 1alpha-hydroxyvitamin D(2) analogues via ring-closing metathesis

scientific article published on 01 March 2003

Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction.

scientific article

Synthesis of diverse macrocyclic peptidomimetics utilizing ring-closing metathesis and solid-phase synthesis

scientific article published on 01 February 2004

Synthesis of substituted pyridines and pyridazines via ring closing metathesis

scientific article published on 06 April 2009

Synthesis of the beta 2 agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents

scientific article published in October 2002

Synthetic Studies Towards the Core Structure of Nakadomarin A by a Thioamide-Based Strategy

scientific article

Tandem ireland-claisen rearrangement ring-closing alkene metathesis in the construction of bicyclic beta-lactam carboxylic esters

scientific article published on 01 June 2000

The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group

scientific article published on 26 August 2011

The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating hydantoin or uracil rings.

scientific article published on 21 June 2011

The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists

scientific article published on 10 November 2016

The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors

scientific article published on 01 January 1996

The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues

scientific article published on 01 March 1996

The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues

scientific article published on 01 September 1994

The squalestatins: synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality

scientific article published on 01 September 1995

Thrombin inhibitors based on [5,5] trans-fused indane lactams

scientific article published on 01 June 1999

Triazenide complexes of the heavier alkaline earths: synthesis, characterization, and suitability for hydroamination catalysis

scientific article published on 12 July 2008

Trifluoromethyl Coordination and CF Bond Activation at Calcium

scientific article published on 01 January 2007

Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors

scientific article published on 26 October 2020

β-Diketiminate C–H activation with heavier group 2 alkyls

scientific article published on 21 September 2009

List of works by Panagiotis Procopiou

2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis.

2-Iodoisatogens: versatile intermediates for the synthesis of nitrogen heterocycles

4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists

A metathesis-based approach to the synthesis of 2-pyridones and pyridines

A metathesis-based approach to the synthesis of furans

A mild and regioselective route to functionalized quinazolines.

Beta-diketiminato calcium and magnesium amides; model complexes for hydroamination catalysis

Bis(diphenylphosphido) derivatives of the heavier group 2 elements

Bis(trimethylsilyl)methyl derivatives of calcium, strontium and barium: potentially useful dialkyls of the heavy alkaline earth elements

Carbodiimide insertion reactions of homoleptic heavier alkaline earth amides and phosphides

Catalytic 2,3,4-hexatriene formation by terminal alkyne coupling at calcium

Cation Charge Density and Precatalyst Selection in Group 2-Catalyzed Aminoalkene Hydroamination

Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis.

Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosi

Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing

Heavier Alkaline Earth Amides as Catalysts for the Tischenko Reaction

Heavier Group 2 Metals and Intermolecular Hydroamination: A Computational and Synthetic Assessment

Heavier alkaline earth catalysts for the intermolecular hydroamination of vinylarenes, dienes, and alkynes

Heavier alkaline earth catalyzed ene-yne cyclizations: atom-efficient access to tetrahydroisoquinoline frameworks

Heavier group 2 element-catalysed hydroamination of isocyanates

Helical structure of tercyclopropanedimethanol in solution

Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists

Imino Sulfinamidines: Synthesis and Coordination Chemistry of a Novel Class of Chiral Bidentate Ligands

Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.

Insertion reactions of beta-diketiminate-stabilised calcium amides with 1,3-dialkylcarbodiimides.

Intramolecular hydroamination of aminoalkenes by calcium and magnesium complexes: a synthetic and mechanistic study.

Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists

Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists

Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation

Modular isoquinoline synthesis using catalytic enolate arylation and in situ functionalization

Novel glucocorticoid antedrugs possessing a 17beta-(gamma-lactone) ring.

Oxazole synthesis with minimal purification: synthesis and application of a ROMPgel Tosmic reagent.

Oxazoline-Promoted Rh-Catalyzed C-H Amidation of Benzene Derivatives with Sulfonamides and Trifluoroacetamide. A Comparative Study

Palladium-catalyzed enolate arylation as a key C-C bond-forming reaction for the synthesis of isoquinolines

Potassium trimethylsilanolate induced cleavage of 1,3-oxazolidin-2- and 5-ones, and application to the synthesis of (R)-salmeterol

Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Syn

Rearrangement of a 16alpha,17alpha-Epoxy-16beta-methylandrostane-17beta-carbothioic Acid to a 17beta-Mercapto-16beta-methylandrostane-17alpha,16alpha-carbolactone

Reversibility in the protonolysis of a beta-diketiminate stabilised calcium bis(trimethylsilyl)amide with benzylamine

Ring-closing metathesis: novel routes to aromatic heterocycles

Ritter-type reactions of N-chlorosaccharin: a method for the electrophilic diamination of alkenes

Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism

Short and efficient syntheses of protoberberine alkaloids using palladium-catalyzed enolate arylation

Solid-phase synthesis of isoxazoles using vinyl ethers as chameleon catches

Studies on the stereochemical assignment of 3-acylidene 2-oxindoles.

Synthesis and characterization of coronanes: multicyclopropane-fused macrocyclic arrays

Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis

Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists

Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups

Synthesis of (R)-alpha-benzylmethionine: a novel rearrangement during alkylation of the Seebach (R)-methionine oxazolidinone

Synthesis of C-19-functionalized 1alpha-hydroxyvitamin D(2) analogues via ring-closing metathesis

Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction.

Synthesis of diverse macrocyclic peptidomimetics utilizing ring-closing metathesis and solid-phase synthesis

Synthesis of substituted pyridines and pyridazines via ring closing metathesis

Synthesis of the beta 2 agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents

Synthetic Studies Towards the Core Structure of Nakadomarin A by a Thioamide-Based Strategy

Tandem ireland-claisen rearrangement ring-closing alkene metathesis in the construction of bicyclic beta-lactam carboxylic esters

The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group

The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating hydantoin or uracil rings.

The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists

The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors

The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues

The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues

The squalestatins: synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality

Thrombin inhibitors based on [5,5] trans-fused indane lactams

Triazenide complexes of the heavier alkaline earths: synthesis, characterization, and suitability for hydroamination catalysis

Trifluoromethyl Coordination and CF Bond Activation at Calcium

Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors

β-Diketiminate C–H activation with heavier group 2 alkyls