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List of works by Darren R Williams

12,23-Dione dammarane triterpenes from Gynostemma longipes and their muscle cell proliferation activities via activation of the AMPK pathway

scientific article published in Scientific Reports

5-Nitro-5'hydroxy-indirubin-3'oxime is a novel inducer of somatic cell transdifferentiation

scientific article

A distinct role for interleukin-6 as a major mediator of cellular adjustment to an altered culture condition

scientific article published on 2 May 2015

A novel indirubin derivative that increases somatic cell plasticity and inhibits tumorigenicity

scientific article published on 20 May 2019

A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening

scientific article

A triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90.

scientific article

A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes

scientific article

Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation.

scientific article published on 15 November 2016

Anti-oxidant activity reinforced reduced graphene oxide/alginate microgels: Mesenchymal stem cell encapsulation and regeneration of infarcted hearts

scientific article published on 24 September 2019

Biotransformed Metabolites of the Hop Prenylflavanone Isoxanthohumol

scientific article published on 22 January 2019

CAF-Derived IL6 and GM-CSF Cooperate to Induce M2-like TAMs-Response

scientific article published on 01 January 2019

CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer.

scientific article published on 06 July 2015

Cancer-Stimulated CAFs Enhance Monocyte Differentiation and Protumoral TAM Activation via IL6 and GM-CSF Secretion

scientific article published on 29 June 2018

Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819

scientific article published on 09 August 2019

Chemical genetics and its application to moonlighting in glycolytic enzymes

scientific article

Chemical targeting of GAPDH moonlighting function in cancer cells reveals its role in tubulin regulation

scientific article published on 9 October 2014

Cyp1a reporter zebrafish reveals target tissues for dioxin.

scientific article published on 21 March 2013

Cytotoxic caffeic acid derivatives from the rhizomes of Cimicifuga heracleifolia.

scientific article published in September 2012

Delineation of the role of glycosylation in the cytotoxic properties of quercetin using novel assays in living vertebrates

scientific article published on 14 November 2014

Development of a Highly Visual, Simple, and Rapid Test for the Discovery of Novel Insulin Mimetics in Living Vertebrates ⬇️

scientific article published on June 12, 2013

Double-stranded DNA-graphene hybrid: preparation and anti-proliferative activity.

scientific article published on 28 February 2014

ENOblock inhibits the pathology of diet-induced obesity

scientific article published in Scientific Reports

ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes.

scientific article published on 08 March 2017

Effects of PTCs on nonsense-mediated mRNA decay are dependent on PTC location

scientific article

Efficient solid-phase synthesis of trifunctional probes and their application to the detection of carbohydrate-binding proteins

scientific article published on 01 November 2005

Fishing for Nature's Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products

scientific article

Fluorescent high-throughput screening of chemical inducers of neuronal differentiation in skeletal muscle cells.

scientific article

Identification of Regulatory-RNAs for Alternative Splicing of Ron Proto-Oncogene

scientific article

Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism

scientific article published in September 2004

Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish

scientific article

Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3

scientific article published on 01 August 2014

Inhibited inositol monophosphatase and decreased myo-inositol concentration improve wasting in skeletal muscles

scientific article published on 01 December 2020

Isolation and Characterization of Isofraxidin 7-O-(6'-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo

scientific article

Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo

scientific article published on 26 July 2016

Lessons from the swamp: developing small molecules that confer salamander muscle cellularization in mammals.

scientific article published on 22 March 2017

Making cardiomyocytes with your chemistry set: Small molecule-induced cardiogenesis in somatic cells.

scientific article

Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment

scientific article

Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction.

scientific article published on 17 March 2010

Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects

scientific article

PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion.

scientific article

Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion

scientific article published on 18 July 2016

Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway.

scientific article published on 2 February 2010

Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity

scientific article

Re-education begins at home: an overview of the discovery of in vivo-active small molecule modulators of endogenous stem cells.

scientific article published on 8 February 2018

Reawakening atlas: chemical approaches to repair or replace dysfunctional musculature.

scientific article

Reprogram or reboot: small molecule approaches for the production of induced pluripotent stem cells and direct cell reprogramming

scientific article

SR proteins regulate V6 exon splicing of CD44 pre-mRNA

scientific article published on 17 August 2016

Small molecules that recapitulate the early steps of urodele amphibian limb regeneration and confer multipotency.

scientific article

Snail, a transcriptional regulator, represses adiponectin expression by directly binding to an E-box motif in the promoter.

scientific article

Some leopards can change their spots: potential repositioning of stem cell reprogramming compounds as anti-cancer agents

scientific article published on 08 May 2016

Synthetic small molecules that induce neurogenesis in skeletal muscle

scientific article published on 10 July 2007

The future is now: cutting edge science and understanding toxicology.

scientific article

Triazine-based tyrosinase inhibitors identified by chemical genetic screening

scientific article published in December 2005

Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7.

scientific article published on July 2010

Visualizing sweetness: increasingly diverse applications for fluorescent-tagged glucose bioprobes and their recent structural modifications

scientific article

ZebIAT, an image analysis tool for registering zebrafish embryos and quantifying cancer metastasis.

scientific article

hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron

scientific journal article

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