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List of works by Roberto Chiarle

A Braf kinase-inactive mutant induces lung adenocarcinoma.

scientific article published on 2 August 2017

A theranostic approach based on the use of a dual boron/Gd agent to improve the efficacy of Boron Neutron Capture Therapy in the lung cancer treatment.

scientific article published on 14 January 2015

ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis.

scientific article published on 5 September 2014

Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas

scientific article published on 27 September 2005

Advances in cancer immunology and cancer immunotherapy

scientific article

An in vivo model of Met-driven lymphoma as a tool to explore the therapeutic potential of Met inhibitors

scientific article published in April 2008

An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen

scientific article

Anaplastic large cell lymphoma: one or more entities among T-cell lymphoma?

scientific article published on December 2009

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

scientific article (publication date: 7 February 2002)

Anaplastic lymphoma kinase: an oncogene for tumor vaccination

scientific article published on 30 March 2009

Autoantibodies to Ezrin are an early sign of pancreatic cancer in humans and in genetically engineered mouse models

scientific article published on 06 September 2013

Autoantibody signature in human ductal pancreatic adenocarcinoma.

scientific article published on 8 September 2007

BRAF gene is not mutated in plasma cell leukemia and multiple myeloma

scientific article published on 01 November 2003

CALming Down T Cell Acute Leukemia ⬇️

scientific article published on April 17, 2012

CD30 in normal and neoplastic cells.

scientific article

CD30 overexpression enhances negative selection in the thymus and mediates programmed cell death via a Bcl-2-sensitive pathway

scientific article published on 01 July 1999

CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation

scientific article published on 01 July 2019

Cell proliferation, bcl-2, c-myc, p53 and apoptosis as indicators of different aggressiveness in small lymphocytic lymphoma (SLL)

scientific article published on 01 September 1997

Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1.

scientific article published on 16 August 2017

Comment on "ALK is a therapeutic target for lethal sepsis".

scientific article

Complete and prolonged response to anti-PD1 therapy in an ALK rearranged lung adenocarcinoma

scientific article published on 27 May 2020

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

scientific article published on 28 December 2016

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

Conditional activation of MET in differentiated skeletal muscle induces atrophy.

scientific article

Confocal microscope analysis and tridimensional reconstruction of papillary thyroid carcinoma nuclei

scientific article

Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma

scientific article published on 28 August 2016

Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3 mutations in normal subjects

scientific article published on 23 May 2011

Detection of immunoglobulin kappa light chain rearrangements by polymerase chain reaction. An improved method for detecting clonal B-cell lymphoproliferative disorders.

scientific article published on August 1999

Detection ofBCL-6 rearrangements andp53 mutations in malt-lymphomas ⬇️

scientific article published on December 1, 1997

Developmentally-faithful and effective human erythropoiesis in immunodeficient and Kit mutant mice

scientific article published on 31 May 2017

Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

scientific article published on 9 March 2016

Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors.

scientific article published on 29 September 2015

Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex.

scientific article published on May 2013

Epitope mapping of spontaneous autoantibodies to anaplastic lymphoma kinase (ALK) in non-small cell lung cancer

scientific article

Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates

scientific article published in October 2003

Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency

scientific article published on 14 December 2015

Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes

scientific article published on 13 August 2010

Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas

article

Expression of the CD31 antigen in normal B-cells and non Hodgkin's lymphomas.

scientific article published in October 2003

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

scientific journal article

Follicular origin of a subset of CD5+ diffuse large B-cell lymphomas

scientific article published on 01 August 2005

Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.

scientific article

FuseFISH: robust detection of transcribed gene fusions in single cells

scientific article published on 27 December 2013

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells

scientific article published on September 2011

Heat shock protein expression in diabetic nephropathy

scientific article

Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

scientific article published on 17 March 2016

High Levels of miR-7-5p Potentiate Crizotinib-Induced Cytokilling and Autophagic Flux by Targeting RAF1 in NPM-ALK Positive Lymphoma Cells

scientific article published on 13 October 2020

High energy shock waves (HESW) increase paclitaxel efficacy in a syngeneic model of breast cancer.

scientific article

Humoral immune responses toward tumor-derived antigens in previously untreated patients with chronic lymphocytic leukemia

scientific article

IL-18 paradox in pancreatic carcinoma: elevated serum levels of free IL-18 are correlated with poor survival

scientific article published in November 2009

IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing.

scientific article

IL10RA Modulates Crizotinib Sensitivity in NPM1-ALK-positive Anaplastic Large Cell Lymphoma

scientific article published on 23 June 2020

Identification of the same HRAS1 mutation in a primary minimally invasive follicular carcinoma of the thyroid gland and its bone metastasis developed 15 years later

scientific article published on 01 March 1995

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances

scientific article published on 03 February 2014

In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth

scientific article published on 5 December 2006

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation

scientific article

Incestuous paternity detected by STR-typing of chorionic villi isolated from archival formalin-fixed paraffin-embedded abortion material using laser microdissection

scientific article published in January 2006

Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma

scientific article published on 01 January 2000

Induction of Germinal Centers by MMTV EncodedSuperantigen on B Cells ⬇️

scientific article published on January 1, 2001

Initiation of translation from a downstream in-frame AUG codon on BRCA1 can generate the novel isoform protein DeltaBRCA1(17aa)

scientific article published on 01 May 2000

Inter- and intratumoral heterogeneity of BCL2 correlates with IgH expression and prognosis in follicular lymphoma.

scientific article

Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth

scientific article

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.

scientific article published on 4 January 2018

Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin

scientific article published in April 2009

Long-term survival of thymoma patients by histologic pattern and proliferative activity

scientific article published on 01 August 1995

Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia

scientific article published on 01 October 2000

MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling

scientific article

Maternal Immunization: New Perspectives on Its Application Against Non-Infectious Related Diseases in Newborns

scientific article

Mechanisms that promote and suppress chromosomal translocations in lymphocytes

scientific article published on January 2011

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

scientific article published in October 2017

Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts

scientific article published on 12 September 2014

NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells

scientific article published on 3 November 2009

NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.

scientific article published on 7 November 2002

Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma

scholarly article

Neuroblastoma-targeted nanoparticles entrapping siRNA specifically knockdown ALK.

scientific article

New and old functions of STAT3: a pivotal target for individualized treatment of cancer

scientific article

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

scientific article published on 17 March 2013

Of alphas and betas: distinct and overlapping functions of STAT3 isoforms

scientific article published on May 2008

Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1.

scientific article published on 23 April 2016

PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma

scientific article

Parp3 promotes long-range end joining in murine cells

article published in the Proceedings of the National Academy of Sciences of the United States of America

Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

scientific article published on 15 February 2017

Primary Cutaneous B-Cell Lymphoblastic Lymphoma Arising from a Long-Standing Lesion in a Child and Review of the Literature

scientific article published on 26 May 2017

Pure Alveolar Rhabdomyosarcoma of the Corpus Uteri: Description of a Case with Increased Serum Level of CA-125 ⬇️

scientific article published on August 1, 1997

Quantification of HER2 and estrogen receptor heterogeneity in breast cancer by single-molecule RNA fluorescence in situ hybridization

scientific article published on March 2017

RHO Family GTPases in the Biology of Lymphoma

scientific article published on 26 June 2019

RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis.

scientific article published on May 2005

Rapid next-generation sequencing aids in diagnosis of transient abnormal myelopoiesis in a phenotypically normal newborn

scientific article published in 2022

Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice

scientific article published on 8 January 2016

Role of CD30 in the maturation of thymocytes and in the pathogenesis of autoimmune diseases.

scientific article published in October 2003

Role of Pax2 in apoptosis resistance and proinvasive phenotype of Kaposi's sarcoma cells

scientific article

Role of the F-box protein Skp2 in lymphomagenesis

scientific article

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

scientific article published on April 2002

STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy.

scientific article published on 5 March 2013

STAT3β controls inflammatory responses and early tumor onset in skin and colon experimental cancer models.

scientific article

Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma

scientific article published on 9 August 2011

Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology

scientific article published on 13 November 2014

Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

scientific article

Stat3 is required for anchorage-independent growth and metastasis but not for mammary tumor development downstream of the ErbB-2 oncogene

scientific article

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

scientific article published in September 2000

The BRAF Pseudogene Is a Proto-Oncogenic Competitive Endogenous RNA ⬇️

scholarly article

The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.

scientific article

The CRISPR/Cas9 System as a Tool to Engineer Chromosomal Translocation In Vivo

scientific article published on 01 January 2018

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase

scientific article

The STAT3 isoforms alpha and beta have unique and specific functions

scientific article published on 14 March 2004

The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic Lymphoma Cell Growth and Migration

scientific article published on 01 May 2007

The anaplastic lymphoma kinase as an oncogene in solid tumors

scientific article published on June 2015

The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation

scientific article

The anaplastic lymphoma kinase in the pathogenesis of cancer

scientific article published on January 2008

The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination

scientific article

The battle against ALK resistance: successes and setbacks.

scientific article published on 25 August 2012

The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.

scientific article

The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway

scientific article published on 25 April 2011

The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers

scientific article published on January 2010

Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study

scientific article published on 22 May 2014

Tissue flow cytometry immunophenotyping in the diagnosis and classification of non-Hodgkin's lymphomas: a retrospective evaluation of 1,792 cases

scientific article published on 16 January 2013

Translocations in normal B cells and cancers: insights from new technical approaches

scientific article published on January 2013

Tumor Resistance against ALK Targeted Therapy-Where It Comes From and Where It Goes

scientific article published on 28 February 2018

Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer.

scientific article published on 16 January 2013

Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma.

scientific article published on 3 December 2018

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase

scientific article

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