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List of works by Meritxell Huch

Building stomach in a dish.

scientific article published in July 2015

Cellular plasticity in the adult liver and stomach.

scientific article published on 30 March 2016

Chromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes

scientific article published on 24 August 2016

Controlled gene expression in primary Lgr5 organoid cultures

scientific article

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

scientific article published on 25 August 2016

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development

article

Definitions for adult stem cells debated

scientific article published in Nature

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand

scientific journal article

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium

scientific article

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

scientific article published on 6 October 2015

Disease modelling in human organoids

scientific article published on 29 July 2019

Dual targeting of G9a and DNMT1 for the treatment of experimental cholangiocarcinoma

scientific article published on 22 November 2020

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

scientific article published on 04 November 2019

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

scientific article published in March 2018

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

scientific article published on 21 January 2022

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure

scientific article published on 26 February 2016

Genome sequencing of normal cells reveals developmental lineages and mutational processes

scientific article published on 29 June 2014

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

scientific article published on 13 November 2017

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection

scientific article

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. ⬇️

scientific article published on 27 January 2013

Intraductal delivery of adenoviruses targets pancreatic tumors in transgenic Ela-myc mice and orthotopic xenografts

scientific article published on January 2013

Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo

scientific article

Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine.

scientific article

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

scientific article

Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool

scientific article published on 12 June 2019

Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease

scientific article published on 13 December 2019

Liver organoids: from basic research to therapeutic applications

scientific article published on 12 July 2019

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

scientific article

Long-term culture of genome-stable bipotent stem cells from adult human liver

scientific article

Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids

scientific article published on 26 February 2020

Modeling mouse and human development using organoid cultures

scientific article

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.

scientific article

Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.

scientific article published on 26 April 2017

Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells

scientific article published in Scientific Reports

Organoid models of human and mouse ductal pancreatic cancer

scientific article

Organoids from adult liver and pancreas: Stem cell biology and biomedical utility

scientific article published on 27 June 2016

Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation

scientific article published on 27 October 2016

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.

scientific article published on December 2015

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

scientific article

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

scientific article published on 17 January 2022

Regenerative biology: The versatile and plastic liver

scientific article published on 01 January 2015

Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting

scientific article published on September 2006

Sox9 marks adult organ progenitors

scientific article published on 01 January 2011

Stem cells and cancer of the stomach and intestine

scientific article published on 08 June 2010

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

scientific article

Targeting the CYP2B 1/cyclophosphamide suicide system to fibroblast growth factor receptors results in a potent antitumoral response in pancreatic cancer models

scientific article published on December 2006

Tat8-TK/GCV suicide gene therapy induces pancreatic tumor regression in vivo.

scientific article published on December 2005

The balancing act of the liver: tissue regeneration versus fibrosis

scientific article published on 02 January 2018

The hope and the hype of organoid research.

scientific article published on March 2017

The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?

scientific article

The plastic liver: differentiated cells, stem cells, every cell?

scientific article

Tissue-specific mutation accumulation in human adult stem cells during life

scientific article published on 3 October 2016

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.

scientific article

Tumours build their niche

journal article; published in Nature on 2017-05-10

Universality of clone dynamics during tissue development

article

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

scientific article

Urokinase-type plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models

scientific article

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