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List of works by Marc van de Wetering

A promoter-level mammalian expression atlas

scientific article

Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected

scientific article published on 15 April 2004

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

scientific journal article

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

scientific article published in December 2003

Crypt stem cells as the cells-of-origin of intestinal cancer

scientific article

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine

scientific article published on 9 June 2005

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

scientific article

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium

scientific article

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

scientific article published on 23 September 2012

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

scientific article published on 28 March 2013

Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles

scientific article

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

scientific article published on 16 December 2019

FANTOM5 CAGE profiles of human and mouse samples

scientific article published on 29 August 2017

Genome sequencing of normal cells reveals developmental lineages and mutational processes

scientific article published on 29 June 2014

Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells

scientific article published on 11 February 2008

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.

scientific article published on 26 March 2015

Highly sensitive proteome analysis of FACS-sorted adult colon stem cells

scientific article

Identification of primary MAFB target genes in multiple myeloma.

scientific article

Identification of two novel regulated serines in the N terminus of beta-catenin

scientific article published in June 2002

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection

scientific article

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. ⬇️

scientific article published on 27 January 2013

Intra-tumour diversification in colorectal cancer at the single-cell level

scientific article published in Nature

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

scientific article

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes ⬇️

scientific article published on February 4, 2011

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

scientific article

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

scientific article published on 01 March 2010

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

scientific article

Long-term culture of genome-stable bipotent stem cells from adult human liver

scientific article

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

scientific article

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms

scientific article published on 14 July 2017

Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis

scientific article

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

scientific article

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells

scientific article

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

scientific article published on 29 April 2019

Origins of lymphatic and distant metastases in human colorectal cancer.

scientific article

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

scientific article

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

scientific article published on January 2017

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

scientific article

Prospective derivation of a living organoid biobank of colorectal cancer patients.

scientific article published on May 2015

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

scientific article

Sequential cancer mutations in cultured human intestinal stem cells

scientific article published on 29 April 2015

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

scientific article (publication date: 14 May 2009)

Single-cell dissection of transcriptional heterogeneity in human colon tumors

scientific article

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

scientific article

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

scientific article

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

scientific article published on 12 June 2012

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

scientific article

The intestinal stem cell

scientific article published on July 2008

Tissue-specific mutation accumulation in human adult stem cells during life

scientific article published on 3 October 2016

Transcription factor achaete scute-like 2 controls intestinal stem cell fate

scientific journal article

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.

scientific article

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

scientific article

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

scientific article published on 30 August 2012

Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

scientific article published on 26 October 2023

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

scientific article

WNT signaling and lymphocyte development

scientific article

Wnt activates the Tak1/Nemo-like kinase pathway

scientific article (publication date: 23 April 2004)

Wnt activation and alternative promoter repression of LEF1 in colon cancer

scientific article published on July 2006

Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer

scientific article published in September 2002

Xenograft and organoid model systems in cancer research

scientific article published on 08 July 2019

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