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List of works by Luis Pereira De Almeida

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory.

scientific article published on 17 June 2016

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

scientific article

Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders

scientific article published on 01 February 2020

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

scientific article published on February 2016

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease

scientific article published in July 2013

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

scientific article

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.

scientific article published on 11 May 2016

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation.

scientific article published on 20 July 2016

Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease

scientific article published on 9 May 2014

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

scientific article published in August 2012

Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

scientific article published on February 2003

Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.

scientific article published in December 2017

Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice

scientific article published on 14 November 2017

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

scientific article published in November 2002

Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins

scientific article published in 2022

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

scientific article

Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro

scientific article

Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9.

scientific article published on 13 September 2016

Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death

scientific article published on 21 June 2015

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

scientific article published on 18 December 2013

Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models

scientific article published on 01 November 2019

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

scientific article

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy

scientific article published on October 2014

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

scientific article published in January 2004

Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs

scientific article published on 01 December 2018

MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma.

scientific article published on 07 April 2015

MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma

scientific article published on 30 November 2012

Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats

scientific article

Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis.

scientific article published in January 2018

Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review

scientific article

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

scientific article published on 11 April 2019

Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice

scientific article published on 08 June 2020

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

scientific article

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells

scientific article published on 03 February 2020

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease

scientific article published on 27 July 2015

Neuropeptide Y stimulates autophagy in hypothalamic neurons

scientific article

Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology

scientific article published in August 2013

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease

scientific journal article

RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3

scientific article published on 28 May 2019

RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease

scientific article

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

scientific article published on 12 July 2018

Role of hypothalamic neurogenesis in feeding regulation

scientific article

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

scientific article

Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

scientific article published on 22 March 2010

Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice

scientific article

Stem Cell-Based Therapies for Polyglutamine Diseases

scientific article published in January 2018

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

scientific article

Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation

scientific article published on 19 November 2019

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

scientific article published on 31 August 2020

Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice

scientific article published on 19 December 2014

Trehalose alleviates the phenotype of Machado-Joseph disease mouse models

scientific article published on 09 April 2020

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment.

scientific article published on 18 June 2013

Unraveling the Role of Ataxin-2 in Metabolism

scientific article published on 20 January 2017

Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease

scientific article published on 21 February 2017

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

article

miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease

scientific article published on 17 January 2020

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