List of works - Jonathan P. Sleeman

'Normalizing' the malignant phenotype of luminal breast cancer cells via alpha(v)beta(3)-integrin

scientific article published on December 2016

A Systematic Approach to Defining the microRNA Landscape in Metastasis.

scientific article

A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4

scientific article

ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.

scientific article

ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients.

scientific article

Accumulation of small hyaluronan oligosaccharides in tumour interstitial fluid correlates with lymphatic invasion and lymph node metastasis.

scientific article

Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of melanoma inhibitory activity.

scientific article published on November 2003

An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis

scientific article

Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent.

scientific article

Author Correction: Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells

scientific article published on 11 December 2019

Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog

scientific article

Autonomous neural axis formation by ectopic expression of the protooncogene c-ski.

scientific article published in December 1997

CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models

scientific article

CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease

scientific article

CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a

scientific article

CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion

scientific article published on 28 June 2011

CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals.

scientific article published on January 2014

CD44 is required for two consecutive steps in HGF/c-Met signaling.

scientific article published on December 2002

CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan

scientific article published on 22 November 2016

CD44 variant-specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages

scientific article published on 01 June 2002

Cancer metastasis as a therapeutic target

scientific article published on 20 March 2010

Cell cycle quiescence can suppress transcription from an ecdysone receptor-based inducible promoter in mammalian cells

scientific article published on May 2009

Characterisation of the murine gene encoding the intracellular hyaluronan receptor IHABP (RHAMM).

scientific article published in January 1999

Collaborative Action of Surface Chemistry and Topography in the Regulation of Mesenchymal and Epithelial Markers and the Shape of Cancer Cells.

scientific article published on 12 October 2016

Concepts of metastasis in flux: the stromal progression model

scientific article published on 21 February 2012

Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family

scientific article

Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats.

scientific article published on 23 August 2013

Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids.

scientific article published in January 2010

Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes

scientific article published on 04 October 2016

Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens

scientific article published on 01 September 2004

Discovery of a novel tumour metastasis-promoting gene, NVM-1.

scientific article published on 8 July 2011

Early cytoskeletal rearrangement during dendritic cell maturation enhances synapse formation and Ca(2+) signaling in CD8(+) T cells

scientific article published on 01 October 2004

Editorial: special issue introduction

scientific article published on 01 April 2017

Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis

scientific article published on 01 December 2003

Extracellular regulation of BMP signaling: welcome to the matrix.

scientific article published on February 2017

Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology.

scientific article published on 2 June 2016

Hyaluronan-oligosaccharide-induced transcription of metalloproteases

scientific article

Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression.

scientific article published on October 1994

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways

scientific article published on 22 August 2013

Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells

scientific article published in Scientific Reports

Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid

scientific article

Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo

scientific article

Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues

scientific article published in August 2004

Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model

scientific article published on 31 December 2013

Interaction of rat tumor cells with blood vessels and lymphatics of the avian chorioallantoic membrane.

scientific article published in October 2001

Introduction of revised "Aims and Scope" for Clinical & Experimental Metastasis

scientific article published on 01 December 2016

LiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cells

scientific article

Loss of CD24 expression promotes ductal branching in the murine mammary gland

scientific article published on 30 March 2010

MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo.

scientific article published on December 2004

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3

scientific article published on October 2016

Metastasis: understanding is the beginning of order in chaos

scientific article published on 10 March 2012

Modeling lymphangiogenesis in a three-dimensional culture system.

scientific article published on 20 April 2008

New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment.

scientific article published on 31 October 2007

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

scientific article

Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44

scientific article published on 03 October 2013

PIPAC puts pressure on peritoneal metastases from pancreatic cancer

scientific article published on 01 June 2017

Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer.

scientific article published on 3 November 2007

Pre-metastatic conditioning of organ microenvironments by tumors: beyond preparing the soil.

scientific article published in November 2015

Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA.

scientific article published in February 2004

RASSF1A inhibits estrogen receptor alpha expression and estrogen-independent signalling: implications for breast cancer development.

scientific article published on 23 January 2012

Role of fibulin-5 in metastatic organ colonization.

scientific article published on 31 March 2011

SnapShot: The epithelial-mesenchymal transition

scientific article published on 01 April 2011

Spatio-temporal patterns of pancreatic cancer cells expressing CD44 isoforms on supported membranes displaying hyaluronic acid oligomers arrays

scientific article

Spatiotemporally controlled induction of gene expression in vivo allows tracking the fate of tumor cells that traffic through the lymphatics

scientific article published on 01 November 2019

Sugars in the microenvironment: the sticky problem of HA turnover in tumors

scientific article

Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes

scientific article published on April 2009

Switch in syndecan-1 and syndecan-4 expression controls maturation associated dendritic cell motility

scientific article published on 01 July 2007

TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)

scientific article

Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+ T-helper cells by induction of FAS-independent T-cell apoptosis

scientific article published on 01 May 2003

The disparate twins: a comparative study of CXCR4 and CXCR7 in SDF-1α-induced gene expression, invasion and chemosensitivity of colon cancer.

scientific article

The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients

scientific article

The lymph node pre-metastatic niche

scientific article

The proteasome inhibitor Bortezomib (Velcade) as potential inhibitor of estrogen receptor-positive breast cancer.

scientific article published on 8 January 2015

The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies

scientific article published on 31 August 2018

Tin Tungstate Nanoparticles: A Photosensitizer for Photodynamic Tumor Therapy

scientific article published on 19 February 2016

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice

scientific article published on 24 November 2014

Tumor lymphatics.

scientific article published on 29 May 2009

Tumor metastasis and the lymphatic vasculature.

scientific article published on December 2009

Tumor metastasis formation: cell-surface proteins confer metastasis-promoting or -suppressing properties.

scientific article

Tumor-initiating properties of breast cancer and melanoma cells in vivo are not invariably reflected by spheroid formation in vitro, but can be increased by long-term culturing as adherent monolayers

scientific article published on 7 September 2012

Uneven distribution of methylation sites within the human papillomavirus la genome: possible relevance to viral gene expression.

scientific article

VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis

scientific article

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

scientific article

Variant exons v6 and v7 together expand the repertoire of glycosaminoglycans bound by CD44

scientific article published on 01 December 1997

Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro

scientific journal article

List of works by Jonathan P. Sleeman

'Normalizing' the malignant phenotype of luminal breast cancer cells via alpha(v)beta(3)-integrin

A Systematic Approach to Defining the microRNA Landscape in Metastasis.

A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4

ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.

ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients.

Accumulation of small hyaluronan oligosaccharides in tumour interstitial fluid correlates with lymphatic invasion and lymph node metastasis.

Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of melanoma inhibitory activity.

An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis

Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent.

Author Correction: Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells

Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog

Autonomous neural axis formation by ectopic expression of the protooncogene c-ski.

CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models

CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease

CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a

CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion

CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals.

CD44 is required for two consecutive steps in HGF/c-Met signaling.

CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan

CD44 variant-specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages

Cancer metastasis as a therapeutic target

Cell cycle quiescence can suppress transcription from an ecdysone receptor-based inducible promoter in mammalian cells

Characterisation of the murine gene encoding the intracellular hyaluronan receptor IHABP (RHAMM).

Collaborative Action of Surface Chemistry and Topography in the Regulation of Mesenchymal and Epithelial Markers and the Shape of Cancer Cells.

Concepts of metastasis in flux: the stromal progression model

Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family

Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats.

Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids.

Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes

Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens

Discovery of a novel tumour metastasis-promoting gene, NVM-1.

Early cytoskeletal rearrangement during dendritic cell maturation enhances synapse formation and Ca(2+) signaling in CD8(+) T cells

Editorial: special issue introduction

Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis

Extracellular regulation of BMP signaling: welcome to the matrix.

Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology.

Hyaluronan-oligosaccharide-induced transcription of metalloproteases

Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression.

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways

Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells

Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid

Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo

Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues

Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model

Interaction of rat tumor cells with blood vessels and lymphatics of the avian chorioallantoic membrane.

Introduction of revised "Aims and Scope" for Clinical & Experimental Metastasis

LiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cells

Loss of CD24 expression promotes ductal branching in the murine mammary gland

MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo.

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3

Metastasis: understanding is the beginning of order in chaos

Modeling lymphangiogenesis in a three-dimensional culture system.

New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment.

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44

PIPAC puts pressure on peritoneal metastases from pancreatic cancer

Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer.

Pre-metastatic conditioning of organ microenvironments by tumors: beyond preparing the soil.

Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA.

RASSF1A inhibits estrogen receptor alpha expression and estrogen-independent signalling: implications for breast cancer development.

Role of fibulin-5 in metastatic organ colonization.

SnapShot: The epithelial-mesenchymal transition

Spatio-temporal patterns of pancreatic cancer cells expressing CD44 isoforms on supported membranes displaying hyaluronic acid oligomers arrays

Spatiotemporally controlled induction of gene expression in vivo allows tracking the fate of tumor cells that traffic through the lymphatics

Sugars in the microenvironment: the sticky problem of HA turnover in tumors

Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes

Switch in syndecan-1 and syndecan-4 expression controls maturation associated dendritic cell motility

TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)

Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+ T-helper cells by induction of FAS-independent T-cell apoptosis

The disparate twins: a comparative study of CXCR4 and CXCR7 in SDF-1α-induced gene expression, invasion and chemosensitivity of colon cancer.

The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients

The lymph node pre-metastatic niche

The proteasome inhibitor Bortezomib (Velcade) as potential inhibitor of estrogen receptor-positive breast cancer.

The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies

Tin Tungstate Nanoparticles: A Photosensitizer for Photodynamic Tumor Therapy

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice

Tumor lymphatics.

Tumor metastasis and the lymphatic vasculature.

Tumor metastasis formation: cell-surface proteins confer metastasis-promoting or -suppressing properties.