List of works - Ulf Nilsson

1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

scientific article published on 20 May 2010

3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3.

scientific article published in July 2005

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

scientific article published on 12 December 2019

A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1

scientific article published on 02 August 2019

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

scientific article

A study of the donor properties of sialyl phosphites having an auxiliary 3-(S)-phenylseleno group

scientific article

Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface

scientific article published on 05 March 2007

Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors

scientific article published on 13 May 2019

An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

scientific article published on 23 January 2019

Arene-anion based arginine-binding motif on a galactose scaffold: structure-activity relationships of interactions with arginine-rich galectins

scientific article published on 07 June 2011

Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors

scientific article published on 5 March 2008

Arynes in the Monoarylation of Unprotected Carbohydrate Amines

scientific article published on 23 January 2018

C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions

scientific article published in August 2005

Carbohydrate functionalization using cationic iron carbonyl complexes

scientific article

Comparative 1H NMR study of hydroxy protons in galabioside and its S-linked 4-thiodisaccharide analogue in aqueous solution

scientific article published on 01 November 1999

Conformational studies on phenyl thioglycosides: a remote effect on disaccharide linkage by phenyl aglycons attenuates recognition of galabiosides by a bacterial adhesin

scientific article

Coupling of <i>N</i>-tosylhydrazones with tetrazoles: synthesis of 2-β-D-glycopyranosylmethyl-5-substituted-2<i>H</i>-tetrazole type glycomimetics

scientific article published on 23 December 2020

Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.

scientific article published on 4 December 2017

Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides

scientific article published in January 2008

Efficient O-Functionalization of Carbohydrates with Electrophilic Reagents

scientific article published on 16 August 2016

Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: galectin oligosaccharide specificity studies in a fluorescence polarization assay.

scientific article

Epimers Switch Galectin-9 Domain Selectivity: 3N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal

scientific article published on 04 December 2019

Extracellular and intracellular small-molecule galectin-3 inhibitors

Flap Dynamics in Aspartic Proteases: A Computational Perspective

scientific article published on 13 February 2016

Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions

scientific article published in November 2004

Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3.

scientific article published on 20 July 2009

Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin

scientific article

Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury

scientific article published on 27 November 2014

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

scientific article

Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice

scientific article published on 25 April 2012

Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro.

scientific article

Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types

scientific article

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

scientific article

Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells

scientific article

Haemophilus influenzae surface fibril (Hsf) is a unique twisted hairpin-like trimeric autotransporter

scientific article

Human trophoblast requires galectin-3 for cell migration and invasion

scientific article published in Scientific Reports

Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

scientific article

Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor

scientific article

In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors

scientific article published on 03 January 2020

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor

scientific article

Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection

scientific article

Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding

scientific article published on 23 January 2019

Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors

scientific article published on 22 July 2013

Ligand binding and complex formation of galectin-3 is modulated by pH variations

scientific article published on 01 January 2014

Ligand induced galectin-3 protein self-association

scientific article published on May 2012

Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans

scientific article published on 26 April 2016

Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers

scientific article published in July 2005

Monovalent interactions of galectin-1

scientific article

Multimeric lactoside "click clusters" as tools to investigate the effect of linker length in specific interactions with peanut lectin, galectin-1, and -3.

scientific article published in July 2010

Mutational tuning of galectin-3 specificity and biological function

scientific article

Oligosaccharide-receptor interaction of the Gal alpha 1-4Gal binding adhesin of Streptococcus suis. Combining site architecture and characterization of two variant adhesin specificities.

scientific article

PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein.

scientific article

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.

scientific article published on 12 April 2016

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C

scientific article

Physical properties of Escherichia coli P pili measured by optical tweezers

scientific article published on 17 September 2004

Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

scientific article

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

scientific article

Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.

scientific article published on 20 May 2008

Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides

scientific article

Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain

scientific article published on 01 August 2018

Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations.

scientific article published on 2 November 2017

Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3

scientific article

Solid-phase extraction for combinatorial libraries.

scientific article

Spindle pole cohesion requires glycosylation-mediated localization of NuMA.

scientific article

Stereo- and regioselective hydroboration of 1-exo-methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors.

scientific article

Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction

scientific article published in February 2005

Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose

scientific article published on February 2016

Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

scientific article

Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli

scientific article published on June 1995

Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions

scientific article published on 11 July 2019

Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins

scientific article

Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters

scientific article published on August 2007

Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects

scientific article published on 01 January 2019

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.

scientific article

Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists

scientific article published on 09 June 2014

Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.

scientific article

Synthesis of 3-azido-3-deoxy-beta-D-galactopyranosides.

scientific article

Synthesis of GD3-lactam: a potential ligand for the development of an anti-melanoma vaccine

scientific article published in April 2002

Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors

scientific article

Synthesis of a 3'-naphthamido-LacNAc fluorescein conjugate with high selectivity and affinity for galectin-3

scientific article published on 15 May 2006

Synthesis of a globotetraose trimer

scientific article

Synthesis of a phenyl thio-beta-D-galactopyranoside library from 1,5-difluoro-2,4-dinitrobenzene: discovery of efficient and selective monosaccharide inhibitors of galectin-7.

scientific article

Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors

scientific article published on 14 March 2007

Synthesis of multivalent lactose derivatives by 1,3-dipolar cycloadditions: selective galectin-1 inhibition

scientific article published on 15 May 2006

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity

scientific article published on 28 December 2017

Taloside inhibitors of galectin-1 and galectin-3

scientific article

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

scientific article

The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins

scientific article

The role of Galectin-3 in α-synuclein-induced microglial activation

scientific article

Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors

scientific article published on 18 October 2005

Tri-isopropylsilyl thioglycosides as masked glycosyl thiol nucleophiles for the synthesis of S-linked glycosides and glyco-conjugates

scientific article published on 01 July 2014

Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1

scientific article published on 23 January 2013

List of works by Ulf Nilsson

1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3.

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

A study of the donor properties of sialyl phosphites having an auxiliary 3-(S)-phenylseleno group

Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface

Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors

An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

Arene-anion based arginine-binding motif on a galactose scaffold: structure-activity relationships of interactions with arginine-rich galectins

Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors

Arynes in the Monoarylation of Unprotected Carbohydrate Amines

C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions

Carbohydrate functionalization using cationic iron carbonyl complexes

Comparative 1H NMR study of hydroxy protons in galabioside and its S-linked 4-thiodisaccharide analogue in aqueous solution

Conformational studies on phenyl thioglycosides: a remote effect on disaccharide linkage by phenyl aglycons attenuates recognition of galabiosides by a bacterial adhesin

Coupling of <i>N</i>-tosylhydrazones with tetrazoles: synthesis of 2-β-D-glycopyranosylmethyl-5-substituted-2<i>H</i>-tetrazole type glycomimetics

Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.

Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides

Efficient O-Functionalization of Carbohydrates with Electrophilic Reagents

Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: galectin oligosaccharide specificity studies in a fluorescence polarization assay.

Epimers Switch Galectin-9 Domain Selectivity: 3N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal

Extracellular and intracellular small-molecule galectin-3 inhibitors

Flap Dynamics in Aspartic Proteases: A Computational Perspective

Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions

Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3.

Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin

Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice

Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro.

Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells

Haemophilus influenzae surface fibril (Hsf) is a unique twisted hairpin-like trimeric autotransporter

Human trophoblast requires galectin-3 for cell migration and invasion

Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor

In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor

Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection

Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding

Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors

Ligand binding and complex formation of galectin-3 is modulated by pH variations

Ligand induced galectin-3 protein self-association

Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans

Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers

Monovalent interactions of galectin-1

Multimeric lactoside "click clusters" as tools to investigate the effect of linker length in specific interactions with peanut lectin, galectin-1, and -3.

Mutational tuning of galectin-3 specificity and biological function

Oligosaccharide-receptor interaction of the Gal alpha 1-4Gal binding adhesin of Streptococcus suis. Combining site architecture and characterization of two variant adhesin specificities.

PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein.

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C

Physical properties of Escherichia coli P pili measured by optical tweezers

Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.

Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides

Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain

Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations.

Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3

Solid-phase extraction for combinatorial libraries.

Spindle pole cohesion requires glycosylation-mediated localization of NuMA.

Stereo- and regioselective hydroboration of 1-exo-methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors.

Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction

Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose

Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli

Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions

Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins

Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters

Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.

Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists

Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.

Synthesis of 3-azido-3-deoxy-beta-D-galactopyranosides.

Synthesis of GD3-lactam: a potential ligand for the development of an anti-melanoma vaccine

Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors