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List of works by Jaroslav Malina

A DNA-binding copper(I) metallosupramolecular cylinder that acts as an artificial nuclease.

scientific article

Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media

scientific article published in April 2001

Chiral discrimination in platinum anticancer drugs.

scientific article

Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog.

scientific article published on 17 August 2007

DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins.

scientific article

DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference

scientific article published on 8 May 2008

DNA condensing effects and sequence selectivity of DNA binding of antitumor noncovalent polynuclear platinum complexes.

scientific article published on 16 January 2014

DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin

scientific article published on 13 May 2011

DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.

scientific article

DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: thermodynamic analysis and chemical probing.

scientific article

DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes ⬇️

scientific article published on November 15, 2003

Design and DNA binding of an extended triple-stranded metallo-supramolecular cylinder.

scientific article published in March 2005

Design, Preparation, and Characterization of Zn and Cu Metallopeptides Based On Tetradentate Aminopyridine Ligands Showing Enhanced DNA Cleavage Activity.

scientific article published on 27 October 2015

Energetics, conformation, and recognition of DNA duplexes containing a major adduct of an anticancer azolato-bridged dinuclear Pt(II) complex

scientific article published on 07 June 2012

Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes

scientific article published in May 2010

Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light

scientific article published on 21 July 2015

Influence of surface shape on DNA binding of bimetallo helicates.

scientific article

Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage.

scientific article

Iron(II) supramolecular helicates condense plasmid DNA and inhibit vital DNA-related enzymatic activities.

scientific article

Iron(II) supramolecular helicates interfere with the HIV-1 Tat-TAR RNA interaction critical for viral replication.

scientific article published on 12 July 2016

Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes

scientific article published on 9 July 2009

Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways

scientific article published on 05 September 2019

Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?

article by Viktor Brabec et al published 2013 in Chemical Science

Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors.

scientific article published on 23 April 2018

NMR analysis of duplex d(CGCGATCGCG)2 modified by Lambda- and Delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study

scientific article published on 07 November 2006

NMR analysis of duplex d(CGCGATCGCG)2 modified by Λ- and Δ-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study.

scientific article published in March 2007

Optically Pure Metallohelices That Accumulate in Cell Nuclei, Condense/Aggregate DNA, and Inhibit Activities of DNA Processing Enzymes

scientific article published on 17 February 2020

Optically pure, water-stable metallo-helical 'flexicate' assemblies with antibiotic activity

scientific article

Recognition of DNA/RNA bulges by antimicrobial and antitumor metallohelices.

scientific article published on 27 July 2015

Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair

scientific article

Shape-selective recognition of DNA abasic sites by metallohelices: inhibition of human AP endonuclease 1.

scientific article published on 4 May 2015

Spontaneous translocation of antitumor oxaliplatin, its enantiomeric analogue, and Cisplatin from one strand to another in double-helical DNA.

scientific article published on 19 July 2013

Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells.

scientific article

Substitution-Inert Polynuclear Platinum Complexes Act as Potent Inducers of Condensation/Aggregation of Short Single- and Double-Stranded DNA and RNA Oligonucleotides

scientific article published on 29 January 2019

Substitution-Inert Polynuclear Platinum Complexes Inhibit Reverse Transcription Preferentially in RNA Triplex-Forming Templates

scientific article published on 29 September 2020

Substitution-Inert Polynuclear Platinum Complexes That Inhibit the Activity of DNA Polymerase in Triplex-Forming Templates

scientific article published on 07 June 2018

Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity

scientific article published on 24 September 2014

The thermodynamics of translesion DNA synthesis past major adducts of enantiomeric analogues of antitumor cisplatin.

scientific article published on 28 February 2012

Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug.

scientific article

Thermodynamic impact of abasic sites on simulated translesion DNA synthesis

scientific article published on 26 May 2014

Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A.

scientific article published on 22 December 2005

Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents.

scientific article

Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study

Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA.

scientific article

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