List of works - Vítor Costa

A yeast model of the Parkinson's disease-associated protein Parkin

scientific article published on 26 February 2015

Accumulation of Non-Superoxide Anion Reactive Oxygen Species Mediates Nitrogen-Limited Alcoholic Fermentation by Saccharomyces cerevisiae ⬇️

scientific article published on October 15, 2010

Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria

scientific article

Acquisition of ethanol tolerance in Saccharomyces cerevisiae: the key role of the mitochondrial superoxide dismutase.

scientific article

Activation of SNF1/AMPK mediates the mitochondrial derepression, resistance to oxidative stress and increased lifespan of cells lacking the phosphatase Sit4p

scientific article published on 25 January 2020

Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging.

scientific article

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

scientific article

Cellular models of aging.

scientific article published on 26 December 2012

Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells.

scientific article

Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells

scientific article published on 12 June 2015

Effect of diflubenzuron on the development of Pinus pinaster seedlings inoculated with the ectomycorrhizal fungus Pisolithus tinctorius.

scientific article published on 11 July 2012

Effect of myricetin, pyrogallol, and phloroglucinol on yeast resistance to oxidative stress.

scientific article published on 27 April 2015

Exploring the power of yeast to model aging and age-related neurodegenerative disorders

scientific article published on November 2016

Glutathione is necessary to ensure benefits of calorie restriction during ageing in Saccharomyces cerevisiae

scientific article published on 18 September 2008

Guidelines and recommendations on yeast cell death nomenclature.

scientific article published in January 2018

Heme as a source of iron to Leishmania infantum amastigotes

scientific article published on 01 November 2008

Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: the involvement of the oxidative stress response regulators Yap1 and Skn7.

scientific article

Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis

scientific article published on 27 December 2007

LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites

scientific article published on 11 March 2015

Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.

scientific article published in June 2003

Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism

scientific article

Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Zn-superoxide dismutase.

scientific article published in February 2005

Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases.

scientific article

Pkh1p-Ypk1p and Pkh1p-Sch9p Pathways Are Activated by Acetic Acid to Induce a Mitochondrial-Dependent Regulated Cell Death

scientific article published on 02 April 2020

Production of orotic acid by a Klura3Δ mutant of Kluyveromyces lactis.

scientific article published on 18 December 2015

Quercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiae

scientific article published on 27 February 2007

Quercetin protects Saccharomyces cerevisiae against oxidative stress by inducing trehalose biosynthesis and the cell wall integrity pathway

scientific article

Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells

scientific article published on 6 January 2014

Requirement of glutathione for Sod1 activation during lifespan extension

scientific article published on 24 August 2010

Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.

scientific article published on 28 June 2011

Sit4 Genetically Interacts with Vps27 to Regulate Mitochondrial Function and Lifespan in Saccharomyces cerevisiae

scientific article published in 2024

The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation

scientific article published on 11 October 2017

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

scientific article

The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae

scientific article published on 01 December 2006

The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.

scientific article

The ceramide-activated protein phosphatase Sit4p controls lifespan, mitochondrial function and cell cycle progression by regulating hexokinase 2 phosphorylation

scientific article

The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids

scientific article published on 14 October 2013

Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism

scientific article published on 15 December 2015

Using yeast to uncover the regulation of protein kinase Cδ by ceramide.

scientific article

Yeast as a platform to uncover ceramide-induced ancient cell death routines ⬇️

scientific article published on January 1, 2012

List of works by Vítor Costa

A yeast model of the Parkinson's disease-associated protein Parkin

Accumulation of Non-Superoxide Anion Reactive Oxygen Species Mediates Nitrogen-Limited Alcoholic Fermentation by Saccharomyces cerevisiae ⬇️

Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria

Acquisition of ethanol tolerance in Saccharomyces cerevisiae: the key role of the mitochondrial superoxide dismutase.

Activation of SNF1/AMPK mediates the mitochondrial derepression, resistance to oxidative stress and increased lifespan of cells lacking the phosphatase Sit4p

Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging.

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

Cellular models of aging.

Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells.

Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells

Effect of diflubenzuron on the development of Pinus pinaster seedlings inoculated with the ectomycorrhizal fungus Pisolithus tinctorius.

Effect of myricetin, pyrogallol, and phloroglucinol on yeast resistance to oxidative stress.

Exploring the power of yeast to model aging and age-related neurodegenerative disorders

Glutathione is necessary to ensure benefits of calorie restriction during ageing in Saccharomyces cerevisiae

Guidelines and recommendations on yeast cell death nomenclature.

Heme as a source of iron to Leishmania infantum amastigotes

Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: the involvement of the oxidative stress response regulators Yap1 and Skn7.

Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis

LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites

Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.

Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism

Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Zn-superoxide dismutase.

Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases.

Pkh1p-Ypk1p and Pkh1p-Sch9p Pathways Are Activated by Acetic Acid to Induce a Mitochondrial-Dependent Regulated Cell Death

Production of orotic acid by a Klura3Δ mutant of Kluyveromyces lactis.

Quercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiae

Quercetin protects Saccharomyces cerevisiae against oxidative stress by inducing trehalose biosynthesis and the cell wall integrity pathway

Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells

Requirement of glutathione for Sod1 activation during lifespan extension

Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.

Sit4 Genetically Interacts with Vps27 to Regulate Mitochondrial Function and Lifespan in Saccharomyces cerevisiae

The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae

The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.

The ceramide-activated protein phosphatase Sit4p controls lifespan, mitochondrial function and cell cycle progression by regulating hexokinase 2 phosphorylation

The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids

Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism

Using yeast to uncover the regulation of protein kinase Cδ by ceramide.

Yeast as a platform to uncover ceramide-induced ancient cell death routines ⬇️