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List of works by Tom Van Wezel

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

article

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

scientific journal article

A procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer

scientific article

A review of the genetic background and tumour profiling in familial colorectal cancer

scientific article published on March 2012

ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism

scientific article

Allelic Switching of , , and during Colorectal Cancer Tumorigenesis

scientific article published on 10 April 2019

Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H.

scientific article

Anticancer activity of novel pyrido[2,3-b]indolizine derivatives: the relevance of phenolic substituents

scientific article published on April 2014

Assessment of a fully automated high-throughput DNA extraction method from formalin-fixed, paraffin-embedded tissue for KRAS, and BRAF somatic mutation analysis.

scientific article published on 29 June 2012

Association between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study

scientific article published on 21 January 2014

BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer

scientific article

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

scientific article

Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.

scientific article published on 25 September 2008

Clinicopathological characteristics of glomeruloid architecture in prostate cancer

scientific article published on 20 February 2020

Colorectal cancer risk variants on 11q23 and 15q13 are associated with unexplained adenomatous polyposis

scientific article

Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas

scientific article published on 15 June 2009

Combined analysis of three lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers

scientific article published on 11 October 2012

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.

scientific article

Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers

scientific article

Comprehensive genetic analysis of seven large families with mismatch repair proficient colorectal cancer

article

Correspondence: SEMA4A variation and risk of colorectal cancer

scientific article

Cribriform architecture in radical prostatectomies predicts oncological outcome in Gleason score 8 prostate cancer patients

scientific article published on 20 July 2020

DNA repair genes are selectively mutated in diffuse large B cell lymphomas

scientific article published on 19 August 2013

Deciphering the genetics of hereditary non-syndromic colorectal cancer

scientific article published on 16 July 2008

Declining detection rates for APC and biallelic MUTYH variants in polyposis patients, implications for DNA testing policy

scientific article published on 16 September 2019

Designing a high-throughput somatic mutation profiling panel specifically for gynaecological cancers

scientific article

Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma

E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines.

scientific article

Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

scientific article

Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort

scientific article published on 20 October 2009

Erratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

article

Everolimus in Patients With Advanced Follicular-Derived Thyroid Cancer: Results of a Phase II Clinical Trial

scientific article published on 01 February 2017

Expression analysis of candidate breast tumour suppressor genes on chromosome 16q

scientific article

Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.

scientific article

Five new mouse susceptibility to colon cancer loci, Scc11–Scc15

scientific article published on 01 October 2003

Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

scientific article published on 01 October 2021

Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours

scientific article

Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.

scientific article published on 28 May 2013

Gene interaction and single gene effects in colon tumour susceptibility in mice

article

Genetic variation of antigen processing machinery components and association with cervical carcinoma

scientific article published on 01 June 2007

Genetics of susceptibility to radiation-induced apoptosis in colon: two loci on Chromosomes 9 and 16

article

Genome haploidisation with chromosome 7 retention in oncocytic follicular thyroid carcinoma.

scientific article

Genome-wide allelic state analysis on flow-sorted tumor fractions provides an accurate measure of chromosomal aberrations.

scientific article published on December 2008

Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas.

scientific article published on 15 April 2008

Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer

scientific article

HLA-G protein expression in colorectal cancer evaluated by immunohistochemistry and western blot analysis: Its expression characteristics remain enigmatic

scientific article published on 10 July 2018

HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression.

scientific article published on 22 February 2007

High frequency of copy-neutral LOH inMUTYH-associated polyposis carcinomas

scientific article published in September 2008

High-resolution copy number analysis of paraffin-embedded archival tissue using SNP BeadArrays.

scientific article

Homozygosity for aCHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype

scientific article published on 01 June 2005

Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas

scientific article published on 06 June 2007

Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G > T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue.

scientific article published in January 2008

Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas

scientific article published on 15 July 2011

Infiltrating leukocytes confound the detection of E-cadherin promoter methylation in tumors

scientific article published in June 2004

Infiltration of Lynch Colorectal Cancers by Activated Immune Cells Associates with Early Staging of the Primary Tumor and Absence of Lymph Node Metastases

scientific article published on 18 January 2012

Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer

scientific article

Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis

scientific article

Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment.

scientific article

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

scientific article published on 3 April 2014

Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps

scientific article published on 02 March 2019

MLPAinter for MLPA interpretation: an integrated approach for the analysis, visualisation and data management of Multiplex Ligation-dependent Probe Amplification ⬇️

scientific article

MUTYH-associated polyposis carcinomas frequently lose HLA class I expression - a common event amongst DNA-repair-deficient colorectal cancers

scientific article published in September 2009

Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles

scientific article

Mass spectrometry-based loss of heterozygosity analysis of single-nucleotide polymorphism loci in paraffin embedded tumors using the MassEXTEND assay: single-nucleotide polymorphism loss of heterozygosity analysis of the protein tyrosine phosphatase

scientific article published on November 2005

Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility

scientific article

Molecular Analysis of Gene Fusions in Bone and Soft Tissue Tumors by Anchored Multiplex PCR–Based Targeted Next-Generation Sequencing

article

Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats

scientific article

Mutational analyses of epidermal growth factor receptor and downstream pathways in adrenocortical carcinoma

scientific article published on June 2013

Near-haploidization significantly associates with oncocytic adrenocortical, thyroid, and parathyroid tumors but not with mitochondrial DNA mutations.

scientific article published on 7 June 2014

Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis

scientific article published in December 2012

PIK3CA kinase domain mutation identifies a subgroup of stage III colon cancer patients with poor prognosis ⬇️

scientific article published on August 10, 2011

Progression and tumor heterogeneity analysis in early rectal cancer.

scientific article

Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers

scientific article (publication date: July 2002)

RNA analysis of cancer predisposing genes in formalin-fixed paraffin-embedded tissue determines aberrant splicing

scientific article published on 30 April 2018

Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.

scientific article

Re: Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis

scientific article

Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer ⬇️

scientific article

Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

scientific article published on 10 November 2011

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

article

Reliable High-Throughput Genotyping and Loss-of-Heterozygosity Detection in Formalin-Fixed, Paraffin-Embedded Tumors Using Single Nucleotide Polymorphism Arrays

scientific article published on 01 November 2005

Retinoic acid receptor and retinoid X receptor subtype expression for the differential diagnosis of thyroid neoplasms.

scientific article published on 20 January 2009

Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing

scientific article published on 07 June 2021

Role of the microenvironment in the tumourigenesis of microsatellite unstable and MUTYH-associated polyposis colorectal cancers.

scientific article published on March 2012

Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients

scientific article published in September 2015

Sensitive and specific KRAS somatic mutation analysis on whole-genome amplified DNA from archival tissues

scientific article published on 03 December 2009

Single nucleotide polymorphism array analysis of chromosomal instability patterns discriminates rectal adenomas from carcinomas

article

Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma.

scientific article

Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

scientific article

Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.

scientific article published on 6 May 2011

The MLH1 c.1852_1853delinsGC (p.K618A) variant in colorectal cancer: genetic association study in 18,723 individuals

scientific article

The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas

scientific article published on 29 September 2020

The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression

scientific article

The complexity of screening PMS2 in DNA isolated from formalin-fixed paraffin-embedded material

scientific article published on 15 October 2019

The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors

scientific article

The importance of a large sample cohort for studies on modifier genes influencing disease severity in FAP patients

scientific article published on 29 December 2013

The natural history of a combined defect in MSH6 and MUTYH in a HNPCC family

scientific article published on 01 January 2007

Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer

scientific article published on 8 December 2010

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

scientific article

cDNA expression profiling of chondrosarcomas: Ollier disease resembles solitary tumours and alteration in genes coding for components of energy metabolism occurs with increasing grade.

scientific article

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