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List of works by Julián Gómez-Cambronero

A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration

scientific article published on February 2013

A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells

scientific article published on 19 January 2016

A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells

scientific article published on 23 December 2016

A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells

scientific article published on 12 February 2013

A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism

scientific article

A systematic approach to the complete study of a signaling molecule: ribosomal p90rsk as an example

scientific article published in May 2001

Binding of GM-CSF to adherent neutrophils activates phospholipase D

scientific article published on 01 March 1999

Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).

scientific article

Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).

scientific article

Characteristics of the binding of platelet-activating factor to platelets of different animal species

scientific article published in October 1984

Cloning of PLD2 from Baculovirus for Studies in Inflammatory Responses ⬇️

scientific article published on January 1, 2012

Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion

scientific article

Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells ⬇️

scientific article published on May 30, 2013

Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.

scientific article

How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD.

scientific article

Human cell line that differentiates to all myeloid lineages and expresses neutrophil secondary granule genes.

scientific article

IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)

scientific article

Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity

scientific article

Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras

scientific article

Intracellular localization of platelet-activating factor synthesis in human neutrophils

scientific article published on 01 August 1988

Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression

scientific article published on 29 July 2013

Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function.

scientific article

Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model

scientific article

Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase

scientific article published on 11 May 2003

Modulation of lyso-platelet activating factor: acetyl-CoA acetyltransferase from rat splenic microsomes. The role of cyclic AMP-dependent protein kinase

scientific article published on 01 June 1985

Modulation of lyso-platelet-activating factor:acetyl-CoA acetyltransferase from rat splenic microsomes. The role of calcium ions

scientific article published in June 1985

New concepts in phospholipase D signaling in inflammation and cancer.

scientific article published on 7 July 2010

Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF.

scientific article published on January 2005

PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases.

scientific article

Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.

scientific article published on 27 July 2006

Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor

scientific article

Phosphatidic acid, phospholipase D and tumorigenesis.

scientific article published on 19 September 2013

Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model ⬇️

scientific article published on June 10, 2013

Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.

scientific article

Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action

scientific article published on 17 November 2011

Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR

scientific article published on 22 January 2007

Phospholipase D: a novel major player in signal transduction

scientific article published on 01 June 1998

Presence of a phospholipase D (PLD) distinct from PLD1 or PLD2 in human neutrophils: immunobiochemical characterization and initial purification.

scientific article

Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD

scientific article

Serum Deprivation Confers the MDA-MB-231 Breast Cancer Line with an EGFR/JAK3/PLD2 System That Maximizes Cancer Cell Invasion ⬇️

scientific article published on December 10, 2012

Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis

scientific article

Synthesis of PAF-acether and blood volume changes in gram-negative sepsis

scientific article published on 01 February 1985

The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF

scientific article

The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7

scientific article published on 01 October 1987

The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis

scientific article

The elucidation of novel SH2 binding sites on PLD2

scientific article

The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).

scientific article

The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D

scientific article

The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion

scientific article published on 19 December 2015

The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2.

scientific article

Thematic minireview series on phospholipase D and cancer

scientific article published on 2 July 2014

Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment

article by Sandra Muñoz-Galván et al published 10 October 2018 in Oncogene

Tyrosine phosphorylation in human neutrophil

scientific article published on 01 August 1989

Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.

scientific article published on 09 March 2009

Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis.

scientific article published on 12 April 2007

p42-MAP kinase is activated in EGF-stimulated interphase but not in metaphase-arrested HeLa cells.

scientific article

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