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List of works by Michael T. Williams

(+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats

scientific article

(+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia.

scientific article

(+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.

scientific article published on 12 July 2008

(+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty.

scientific article

(±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain.

scientific article published on August 2012

3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory.

scientific article

6-Hydroxydopamine-Induced Dopamine Reductions in the Nucleus Accumbens, but not the Medial Prefrontal Cortex, Impair Cincinnati Water Maze Egocentric and Morris Water Maze Allocentric Navigation in Male Sprague-Dawley Rats.

scientific article published on 22 March 2016

A Single High Dose of Methamphetamine Reduces Monoamines and Impairs Egocentric and Allocentric Learning and Memory in Adult Male Rats.

scientific article published on 9 February 2018

A better approach to in vivo developmental neurotoxicity assessment: Alignment of rodent testing with effects seen in children after neurotoxic exposures.

scientific article published on 12 March 2018

A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization

scientific article published on 4 September 2016

A new model of Pde4d deficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects.

scientific article

Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice

scientific article

Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.

scientific article

Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats

scientific article published in November 2004

Administration of D,L-fenfluramine to rats produces learning deficits in the Cincinnati water maze but not the Morris water maze: relationship to adrenal cortical output

scientific article published in November 2002

Adulthood nicotine treatment alleviates behavioural impairments in rats neonatally treated with quinpirole: possible roles of acetylcholine function and neurotrophic factor expression

scientific article published in March 2004

Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse.

scientific article

Assessing spatial learning and memory in rodents

scientific article

Behavioral and growth effects induced by low dose methamphetamine administration during the neonatal period in rats.

scientific article

CRF administered to pregnant rats alters offspring behavior and morphology

scientific article published on 01 September 1995

Changes in the hormonal concentrations of pregnant rats and their fetuses following multiple exposures to a stressor during the third trimester

scientific article

Characterization of Motor and Non-Motor Behavioral Alterations in the Dj-1 (PARK7) Knockout Rat

scientific article published on 27 June 2019

Chronic social defeat, but not restraint stress, alters bladder function in mice

scientific article

Cincinnati water maze: A review of the development, methods, and evidence as a test of egocentric learning and memory.

scientific article

Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8.

scientific article published on 31 January 2018

Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA

scientific article

Comparison of (+)‐methamphetamine, ±‐Methylenedioxymethamphetamine, (+)‐amphetamine and ±‐fenfluramine in rats on egocentric learning in the Cincinnati water maze

scientific article published on October 8, 2010

Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat.

scientific article published on September 2006

Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague–Dawley rats: Effects of anxiolytic and anxiogenic agents

scientific article published on September 24, 2010

Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats

scientific article

Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency

scientific article

Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice

scientific journal article

Deltamethrin Exposure Daily From Postnatal Day 3-20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits

scientific article published on 01 June 2019

Developmental 3,4-methylenedioxymethamphetamine (MDMA) impairs sequential and spatial but not cued learning independent of growth, litter effects or injection stress

scientific article published in April 2003

Developmental D-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory.

scientific article published in June 2003

Developmental effects of +/-3,4-methylenedioxymethamphetamine on spatial versus path integration learning: effects of dose distribution

scientific article

Developmental manganese exposure in combination with developmental stress and iron deficiency: Effects on behavior and monoamines.

scientific article published on 11 June 2016

Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory.

scientific article

Developmental manganese, lead, and barren cage exposure have adverse long-term neurocognitive, behavioral and monoamine effects in Sprague-Dawley rats.

scientific article published on 6 April 2018

Developmental stress and lead (Pb): Effects of maternal separation and/or Pb on corticosterone, monoamines, and blood Pb in rats

scientific article

Developmental treatment with the dopamine D2/3 agonist quinpirole selectively impairs spatial learning in the Morris water maze.

scientific article published on 30 September 2008

Differential effects of perinatal exposure to antidepressants on learning and memory, acoustic startle, anxiety, and open-field activity in Sprague-Dawley rats.

scientific article

Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats

scientific article

Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning.

scientific article

Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats

scientific article published on 21 March 2012

Effect of +-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats

scientific article published on 29 May 2008

Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice.

scientific article

Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice.

scientific article

Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats.

scientific article

Effects of Acute Exposure of Permethrin in Adult and Developing Sprague-Dawley Rats on Acoustic Startle Response and Brain and Plasma Concentrations

scientific article published on 01 October 2018

Effects of Housing on Methamphetamine-Induced Neurotoxicity and Spatial Learning and Memory.

scientific article

Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats

scientific article published on 5 November 2016

Effects of Preweaning Manganese in Combination with Adult Striatal Dopamine Lesions on Monoamines, BDNF, TrkB, and Cognitive Function in Sprague-Dawley Rats

scientific article published on 05 January 2019

Effects of acute deltamethrin exposure in adult and developing Sprague-Dawley rats on acoustic startle response in relation to deltamethrin brain and plasma concentrations

scientific article published on 01 March 2019

Effects of centrally administered corticotropin-releasing factor (CRF) and alpha-helical CRF on the vocalizations of isolated guinea pig pups

scientific article

Effects of developmental exposure to manganese and/or low iron diet: Changes to metal transporters, sucrose preference, elevated zero-maze, open-field, and locomotion in response to fenfluramine, amphetamine, and MK-801

scientific article

Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone

scientific article

Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats

scientific article published on October 8, 2010

Effects of dietary phytoestrogen exposure during perinatal period

scientific article published on 28 July 2005

Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels

scientific article

Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague-Dawley rats

scientific article published on 27 March 2019

Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: effects of dose and rearing conditions.

scientific article

Effects of neonatal methamphetamine treatment on adult stress-induced corticosterone release in rats

scientific article

Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug

scientific article

Effects of prenatal cocaine on Morris and Barnes maze tests of spatial learning and memory in the offspring of C57BL/6J mice

scientific article published in July 2000

Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats

scientific article published on 28 July 2010

Electroencephalographic and convulsive effects of binge doses of (+)-methamphetamine, 5-methoxydiisopropyltryptamine, and (±)-3,4-methylenedioxymethamphetamine in rats.

scientific article published on January 2012

Elevations in plasmatic titers of corticosterone and aldosterone, in the absence of changes in ACTH, testosterone, or glial fibrillary acidic protein, 72 h following D,L-fenfluramine or D-fenfluramine administration to rats

scientific article

Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning.

scientific article published in August 2004

Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits.

scientific article published on 29 May 2013

Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain

scientific article published on November 2004

Impaired spatial and sequential learning in rats treated neonatally with D-fenfluramine

scientific article published in August 2002

Impairment of cognitive flexibility in type 2 diabetic db/db mice

scientific article published on 26 May 2019

In Utero and Lactational Exposure to PCBs in Mice: Adult Offspring Show Altered Learning and Memory Depending on Cyp1a2 and Ahr Genotypes

scientific article published on May 13, 2011

In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.

scientific article

Infection-induced endothelial amyloids impair memory

scientific article published on 18 June 2019

Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats.

scientific article

Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers

scientific article published on 06 June 2019

Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects

scientific article published on 18 June 2019

Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment.

scientific article published on 7 July 2017

Litter effects: Comments on Golub and Sobin's "Statistical modeling of litter as a random effect in mixed models to manage "intralitter likeness""

scientific article published on 11 December 2019

Long-term effects of neonatal methamphetamine exposure in rats on spatial learning in the Barnes maze and on cliff avoidance, corticosterone release, and neurotoxicity in adulthood

scientific article published in December 2003

Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes

scientific article

Mechanisms involved in the neurotoxic and cognitive effects of developmental methamphetamine exposure

scientific article published on 13 June 2016

Metal bashing: iron deficiency and manganese overexposure impact on peripheral nerves

scientific article published on 17 January 2019

Methamphetamine exposure during the preweanling period causes prolonged changes in dorsal striatal protein kinase A activity, dopamine D2-like binding sites, and dopamine content

scientific article published in June 2003

Methamphetamine exposure from postnatal day 11 to 20 causes impairments in both behavioral strategies and spatial learning in adult rats

scientific article published in December 2002

Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats

scientific article published in December 2004

Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes

scientific article published on 25 April 2019

Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness.

scientific article

Na,K-ATPase and the role of alpha isoforms in behavior

scientific article published in December 2007

Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits.

scientific article

Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats.

scientific article

Neonatal methamphetamine administration induces region-specific long-term neuronal morphological changes in the rat hippocampus, nucleus accumbens and parietal cortex.

scientific article

Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin

scientific article

Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats.

scientific article

Neonatal quinpirole treatment impairs Morris water task performance in early postweanling rats: relationship to increases in corticosterone and decreases in neurotrophic factors

scientific article

Neurobehavioral Effects from Developmental Methamphetamine Exposure

scientific article

Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine

scientific article

Neurotoxic (+)-methamphetamine treatment in rats increases brain-derived neurotrophic factor and tropomyosin receptor kinase B expression in multiple brain regions

scientific article

Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior.

scientific article published in April 2017

Periadolescent rats (P41-50) exhibit increased susceptibility to D-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60).

scientific article

Perinatal exposure to the selective serotonin reuptake inhibitor citalopram alters spatial learning and memory, anxiety, depression, and startle in Sprague-Dawley rats.

scientific article published on 31 August 2016

Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.

scientific article published on 23 March 2017

Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice

scientific article published on 10 May 2017

Plasma cortisol levels of dogs at a county animal shelter

scientific article published in September 1997

Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F1 fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects

scientific article published on 18 December 2018

Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine.

scientific article

Preweaning treatment with methamphetamine induces increases in both corticosterone and ACTH in rats

scientific article published in September 2000

Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome.

scientific article

Prolonged methamphetamine exposure during a critical period in neonatal Sprague Dawley rats does not exacerbate egocentric and allocentric learning deficits but increases reference memory impairments

scientific article published on 11 February 2020

Refining the critical period for methamphetamine-induced spatial deficits in the Morris water maze

scientific article published on 9 April 2003

Reprint of "Value of water mazes for assessing spatial and egocentric learning and memory in rodent basic research and regulatory studies".

scientific article published on 09 June 2015

Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse

scientific article

Stress during pregnancy alters rat offspring morphology and ultrasonic vocalizations

scientific article published on 01 February 1998

Stress during pregnancy alters the offspring hypothalamic, pituitary, adrenal, and testicular response to isolation on the day of weaning

scientific article published on 01 November 1999

Systemic and behavioral effects of intranasal administration of silver nanoparticles

scientific article

Targeted mutations in the Na,K-ATPase α 2 isoform confer ouabain resistance and result in abnormal behavior in mice.

scientific article

Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

scientific article

The distribution of radiolabeled corticotropin-releasing factor in pregnant rats: an investigation of placental transfer to the fetuses

scientific article published in June 1998

The effects of adulthood nicotine treatment on D2-mediated behavior and neurotrophins of rats neonatally treated with quinpirole

scientific article published in April 2006

The effects of adulthood olanzapine treatment on cognitive performance and neurotrophic factor content in male and female rats neonatally treated with quinpirole

scientific article published in October 2006

The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory

scientific article

Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.

scientific article published on 27 February 2013

Treatment with MDMA from P11-20 disrupts spatial learning and path integration learning in adolescent rats but only spatial learning in older rats.

scientific article

Value of water mazes for assessing spatial and egocentric learning and memory in rodent basic research and regulatory studies.

scientific article published on 10 August 2014