List of works - Daniela Fattori

4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.

scientific article published on 18 September 2011

A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand

scientific article published in August 2005

A new method for chemoselective conjugation of unprotected peptides to dauno- and doxorubicin.

scientific article

A practical approach to the synthesis of hairpin polyamide–peptide conjugates through the use of a safety-catch linker

scientific article published on 01 April 2002

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies

scientific article

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.

scientific article published on 26 February 2011

Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease

scientific article

Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification

scientific article published on 25 May 2013

Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-fluorobenzothiophenes and benzofurans.

scientific article published on 24 February 2015

Bradykinin receptor antagonists--a review of the patent literature 2005-2008.

scientific article published on July 2009

Cinnamic acids and mono-substituted benzoic acids as useful capping groups for the preparation of hNK2 receptor antagonists

scientific article

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. Synthesis and SAR of alpha,alpha-dimethylglycine sulfonamides

scientific article published in June 2006

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 2. Synthesis and structure-activity relationships of alpha,alpha-cycloalkylglycine sulfonamides.

scientific article published in February 2007

Fragment-Based Ligand Discovery

Fragment-based approach to drug lead discovery: overview and advances in various techniques

scientific article

Highly stereoselective, total synthesis of β-c-hexopyranosyl derivatives

Histone deacetylase inhibitors: from bench to clinic

scientific article published on 05 February 2008

Molecular recognition: the fragment approach in lead generation.

scientific article

Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus

scientific article

Probing the active site of the hepatitis C virus serine protease by fluorescence resonance energy transfer

scientific article published in May 2000

Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures.

scientific article

Small molecule antagonists of the tachykinin NK 2 receptor.

scientific article published on March 2004

Solid-phase synthesis of unsymmetrical ureas through the use of Kenner safety-catch linker

Structure-activity relationships of 6-methyl-benzo[b]thiophene-2-carboxylic acid (1-[(S)-1-benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl]cyclopentyl)amide, potent antagonist of the neurokinin-2 receptor

scientific article

Synthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide-, polyamide- and PNA-conjugates.

scientific article

The Demjanov and Tiffeneau-Demjanov one-carbon ring enlargements of 2-aminomethyl-7-oxabicyclo[2.2.1]heptane derivatives. The stereo- and regioselective additions of 8-oxabicyclo[3.2.1]oct-6-en-2-one to soft electrophiles

article

The Syntheses of 3- and 4-Deoxy-hexoses

The electron-releasing homoconjugated carbonyl group. Application to the total syntheses of 3-deoxy-, 4-deoxy-hexose, lividosamine and derivatives

Total asymmetric syntheses of 3- and 4-deoxy-hexoses and derivatives

Total asymmetric syntheses of d-lividosamine and 2-acetamido-2,3-dideoxy-d-arabino-hexose derivatives

alpha,alpha-Cyclic aminoacids as useful scaffolds for the preparation of hNK(2) receptor antagonists

scientific article

alpha,alpha-Cyclopentaneglycine dipeptides capped with biaryls as tachykinin NK(2) receptor antagonists.

scientific article

hNK2 receptor antagonists. The use of intramolecular hydrogen bonding to increase solubility and membrane permeability

scientific article

List of works by Daniela Fattori

4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.

A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand

A new method for chemoselective conjugation of unprotected peptides to dauno- and doxorubicin.

A practical approach to the synthesis of hairpin polyamide–peptide conjugates through the use of a safety-catch linker

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.

Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease

Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification

Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-fluorobenzothiophenes and benzofurans.

Bradykinin receptor antagonists--a review of the patent literature 2005-2008.

Cinnamic acids and mono-substituted benzoic acids as useful capping groups for the preparation of hNK2 receptor antagonists

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. Synthesis and SAR of alpha,alpha-dimethylglycine sulfonamides

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 2. Synthesis and structure-activity relationships of alpha,alpha-cycloalkylglycine sulfonamides.

Fragment-Based Ligand Discovery

Fragment-based approach to drug lead discovery: overview and advances in various techniques

Highly stereoselective, total synthesis of β-c-hexopyranosyl derivatives

Histone deacetylase inhibitors: from bench to clinic

Molecular recognition: the fragment approach in lead generation.

Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus

Probing the active site of the hepatitis C virus serine protease by fluorescence resonance energy transfer

Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures.

Small molecule antagonists of the tachykinin NK 2 receptor.

Solid-phase synthesis of unsymmetrical ureas through the use of Kenner safety-catch linker

Structure-activity relationships of 6-methyl-benzo[b]thiophene-2-carboxylic acid (1-[(S)-1-benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl]cyclopentyl)amide, potent antagonist of the neurokinin-2 receptor

Synthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide-, polyamide- and PNA-conjugates.

The Demjanov and Tiffeneau-Demjanov one-carbon ring enlargements of 2-aminomethyl-7-oxabicyclo[2.2.1]heptane derivatives. The stereo- and regioselective additions of 8-oxabicyclo[3.2.1]oct-6-en-2-one to soft electrophiles

The Syntheses of 3- and 4-Deoxy-hexoses

The electron-releasing homoconjugated carbonyl group. Application to the total syntheses of 3-deoxy-, 4-deoxy-hexose, lividosamine and derivatives

Total asymmetric syntheses of 3- and 4-deoxy-hexoses and derivatives

Total asymmetric syntheses of d-lividosamine and 2-acetamido-2,3-dideoxy-d-arabino-hexose derivatives

alpha,alpha-Cyclic aminoacids as useful scaffolds for the preparation of hNK(2) receptor antagonists

alpha,alpha-Cyclopentaneglycine dipeptides capped with biaryls as tachykinin NK(2) receptor antagonists.

hNK2 receptor antagonists. The use of intramolecular hydrogen bonding to increase solubility and membrane permeability